A spatial case-control study on symptomatic and inapparent primary dengue infections in an endemic city in Brazil

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorFIGUEIREDO, Gerusa
dc.contributor.authorCHIARAVALLOTI, Francisco
dc.contributor.authorCAMPOS, Sergio
dc.contributor.authorPELLINI, Alessandra Cristina Guedes
dc.contributor.authorFELIX, Alvina Clara
dc.contributor.authorLUNA, Expedito
dc.date.accessioned2024-04-05T19:34:31Z
dc.date.available2024-04-05T19:34:31Z
dc.date.issued2024
dc.description.abstractWe conducted a spatial case-control study nested in a dengue incidence cohort to explore the role of the spatial and socioeconomic factors in the proportion of symptomatic (cases) and inapparent primary dengue virus infections (controls). Cohort participants were children and adolescents (2 to 16 years of age) at the beginning of the follow-up. Case definitions were, for symptomatic cases, fever plus a positive lab result for acute dengue (NS1, RT-PCR, ELISA IgM/IgG), and for inapparent infection a positive result for dengue IgG (ELISA) in subjects without symptoms and with a previously negative result at baseline. The covariates included sociodemographic factors, residential location, and socioeconomic context variables of the census tracts of residence of cases and controls. We used principal component analysis to reduce the contextual covariates, with the component values assigned to each one based on their residences. The data were modeled in a Bayesian context, considering the spatial dependence. The final sample consisted of 692 children, 274 cases and 418 controls, from the first year of follow-up (2014-2015). Being male, older age, higher educational level of the head of the family and having a larger number of rooms in the household were associated with a greater chance of presenting dengue symptomatic infection at the individual level. The contextual covariates were not associated with the outcome. Inapparent dengue infection has extensive epidemiological consequences. Relying solely on notifications of symptomatic dengue infections underestimates the number of cases, preserves a silent source of the disease, potentially spreading the virus to unaffected areas.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexScopus
dc.description.indexDimensions
dc.description.indexWoS
dc.description.sponsorshipSanofi Pasteur
dc.description.sponsorship[DNG28]
dc.identifier.citationREVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO, v.66, article ID e12, 9p, 2024
dc.identifier.doi10.1590/S1678-9946202466012
dc.identifier.eissn1678-9946
dc.identifier.issn0036-4665
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/58976
dc.language.isoeng
dc.publisherINST MEDICINA TROPICAL SAO PAULOeng
dc.relation.ispartofRevista do Instituto de Medicina Tropical de Sao Paulo
dc.rightsopenAccesseng
dc.rights.holderCopyright INST MEDICINA TROPICAL SAO PAULOeng
dc.subjectInapparent dengueeng
dc.subjectDengue virus infectioneng
dc.subjectCohort studyeng
dc.subjectSpacial case control studyeng
dc.subject.wosInfectious Diseaseseng
dc.subject.wosParasitologyeng
dc.subject.wosTropical Medicineeng
dc.titleA spatial case-control study on symptomatic and inapparent primary dengue infections in an endemic city in Brazileng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalCHIARAVALLOTI, Francisco:Univ Sao Paulo, Fac Saude Publ, Dept Epidemiol, Sao Paulo, SP, Brazil
hcfmusp.author.externalPELLINI, Alessandra Cristina Guedes:Univ Nove de Julho, Programa Posgrad Cidades Inteligentes & Sustentave, Sao Paulo, SP, Brazil
hcfmusp.citation.scopus0
hcfmusp.contributor.author-fmusphcGERUSA MARIA FIGUEIREDO
hcfmusp.contributor.author-fmusphcSERGIO ROBERTO DE SOUZA LEAO DA COSTA CAMPOS
hcfmusp.contributor.author-fmusphcALVINA CLARA FELIX
hcfmusp.contributor.author-fmusphcEXPEDITO JOSE DE ALBUQUERQUE LUNA
hcfmusp.description.articlenumbere12
hcfmusp.description.volume66
hcfmusp.origemWOS
hcfmusp.origem.dimensionspub.1168987399
hcfmusp.origem.pubmed38381897
hcfmusp.origem.scopus2-s2.0-85185848391
hcfmusp.origem.wosWOS:001172880100001
hcfmusp.publisher.citySAO PAULOeng
hcfmusp.publisher.countryBRAZILeng
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hcfmusp.scopus.lastupdate2024-05-17
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