Human kidney damage in fatal dengue hemorrhagic fever results of glomeruli injury mainly induced by IL17

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Arquivos
art_PAGLIARI_Human_kidney_damage_in_fatal_dengue_hemorrhagic_fever_2016.PDF (1.66 MB)
Citações na Scopus
30
Tipo de produção
article
Data de publicação
2016
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER SCIENCE BV
Autores
QUARESMA, Juarez Antonio Simoes
CARVALHO, Leda Viegas de
VITORIA, Webster Oliveira
PENNY, Ricardo
VASCONCELOS, Barbara Cristina Baldez
VASCONCELOS, Pedro Fernando da Costa
Citação
JOURNAL OF CLINICAL VIROLOGY, v.75, p.16-20, 2016
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Acute kidney injury is an unusual complication during dengue infection. The objective of this study was to better identify the characteristics of glomerular changes focusing on in situ immune cells and cytokines. An immunohistochemical assay was performed on 20 kidney specimens from fatal human cases of dengue hemorrhagic fever (DHF). It was observed a lymphomononuclear infiltrate, neutrophils and nuclear fragmentation in the glomeruli, hydropic degeneration, nuclear retraction, eosinophilic tubules and intense acute congestion. Sickle erythrocytes were frequent in glomeruli and inflammatory infiltrate. The glomeruli presented endothelial swelling and mesangial proliferation. Lymphocytes CD4+ predominated over CD8+ T cells, B cells and natural killer cells. There were also an expressive number of macrophagic CD68+ cells. 5100, Foxp3 and CD123 cells were not identified. Cells expressing IL17 and IL18+ cytokines predominated in the renal tissues, while IL4, IL6, IL10, IL13, TNF-alpha and IFN-gamma were rarely visualized. The high number of cells expressing IL17 and IL18+ could reflect the acute inflammatory response and possibly contribute to the local lesion. CD8+ T cells could play a role in the cytotoxic response. DHF is a multifactorial disease of capillary leakage associated with a ""Tsunami of cytokines expression"". The large numbers of cells expressing IL17 seems to play a role favoring the increased permeability.
Palavras-chave
Dengue, Kidney, Immunohistochemistry, Cells, Cytokinesa
URI
https://observatorio.fm.usp.br/handle/OPI/13515
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/06
Artigos e Materiais de Revistas Científicas - LIM/53
Artigos e Materiais de Revistas Científicas - ODS/03