Human kidney damage in fatal dengue hemorrhagic fever results of glomeruli injury mainly induced by IL17

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorPAGLIARI, Carla
dc.contributor.authorQUARESMA, Juarez Antonio Simoes
dc.contributor.authorKANASHIRO-GALO, Luciane
dc.contributor.authorCARVALHO, Leda Viegas de
dc.contributor.authorVITORIA, Webster Oliveira
dc.contributor.authorSILVA, Wellington Luiz Ferreira da
dc.contributor.authorPENNY, Ricardo
dc.contributor.authorVASCONCELOS, Barbara Cristina Baldez
dc.contributor.authorVASCONCELOS, Pedro Fernando da Costa
dc.contributor.authorDUARTE, Maria Irma Seixas
dc.date.accessioned2016-03-14T14:28:52Z
dc.date.available2016-03-14T14:28:52Z
dc.date.issued2016
dc.description.abstractAcute kidney injury is an unusual complication during dengue infection. The objective of this study was to better identify the characteristics of glomerular changes focusing on in situ immune cells and cytokines. An immunohistochemical assay was performed on 20 kidney specimens from fatal human cases of dengue hemorrhagic fever (DHF). It was observed a lymphomononuclear infiltrate, neutrophils and nuclear fragmentation in the glomeruli, hydropic degeneration, nuclear retraction, eosinophilic tubules and intense acute congestion. Sickle erythrocytes were frequent in glomeruli and inflammatory infiltrate. The glomeruli presented endothelial swelling and mesangial proliferation. Lymphocytes CD4+ predominated over CD8+ T cells, B cells and natural killer cells. There were also an expressive number of macrophagic CD68+ cells. 5100, Foxp3 and CD123 cells were not identified. Cells expressing IL17 and IL18+ cytokines predominated in the renal tissues, while IL4, IL6, IL10, IL13, TNF-alpha and IFN-gamma were rarely visualized. The high number of cells expressing IL17 and IL18+ could reflect the acute inflammatory response and possibly contribute to the local lesion. CD8+ T cells could play a role in the cytotoxic response. DHF is a multifactorial disease of capillary leakage associated with a ""Tsunami of cytokines expression"". The large numbers of cells expressing IL17 seems to play a role favoring the increased permeability.
dc.description.indexMEDLINE
dc.description.sponsorshipNational Institute of Science and Technology for Viral Hemorrhagic Fevers-INCT-FHV INCT-FHV (MCT/CNPq/FNDCT/CAPES/FAPESPA) [15/2008, 573739/2008-0]
dc.description.sponsorshipCNPq [501549/2003-0, 301641/2010-2]
dc.description.sponsorshipInstituto de Assistencia Medica ao Servidor Publico Estadual-CNPq (National Counsel of Technological and Scientific Development)
dc.identifier.citationJOURNAL OF CLINICAL VIROLOGY, v.75, p.16-20, 2016
dc.identifier.doi10.1016/j.jcv.2015.12.005
dc.identifier.eissn1873-5967
dc.identifier.issn1386-6532
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/13515
dc.language.isoeng
dc.publisherELSEVIER SCIENCE BV
dc.relation.ispartofJournal of Clinical Virology
dc.rightsrestrictedAccess
dc.rights.holderCopyright ELSEVIER SCIENCE BV
dc.subjectDengue
dc.subjectKidney
dc.subjectImmunohistochemistry
dc.subjectCells
dc.subjectCytokinesa
dc.subject.othervirus-infection
dc.subject.otherrenal-failure
dc.subject.otherhuman liver
dc.subject.otherhistopathology
dc.subject.otherresponses
dc.subject.wosVirology
dc.titleHuman kidney damage in fatal dengue hemorrhagic fever results of glomeruli injury mainly induced by IL17
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalQUARESMA, Juarez Antonio Simoes:Univ Estado Para, Belem, Para, Brazil; UFPA, Nucleo Med Trop, Belem, Para, Brazil
hcfmusp.author.externalCARVALHO, Leda Viegas de:Hosp Guilherme Alvaro, Secao Anat Patol, Santos, SP, Brazil
hcfmusp.author.externalVITORIA, Webster Oliveira:Inst Assistencia Medica Ao Servidor Publ Estadual, Programa Posgrad Ciencias Saude, Sorocaba, SP, Brazil
hcfmusp.author.externalPENNY, Ricardo:Hosp Guilherme Alvaro, Secao Anat Patol, Santos, SP, Brazil
hcfmusp.author.externalVASCONCELOS, Barbara Cristina Baldez:Univ Estado Para, Belem, Para, Brazil; Inst Evandro Chagas, Rodovia Br 316,Km 07,S-N, BR-67030000 Ananindeua, Para, Brazil
hcfmusp.author.externalVASCONCELOS, Pedro Fernando da Costa:Univ Estado Para, Belem, Para, Brazil; Inst Evandro Chagas, Rodovia Br 316,Km 07,S-N, BR-67030000 Ananindeua, Para, Brazil
hcfmusp.citation.scopus30
hcfmusp.contributor.author-fmusphcCARLA PAGLIARI
hcfmusp.contributor.author-fmusphcLUCIANE KANASHIRO GALO
hcfmusp.contributor.author-fmusphcWELLINGTON LUIZ FERREIRA DA SILVA
hcfmusp.contributor.author-fmusphcMARIA IRMA SEIXAS DUARTE
hcfmusp.description.beginpage16
hcfmusp.description.endpage20
hcfmusp.description.volume75
hcfmusp.origemWOS
hcfmusp.origem.pubmed26741825
hcfmusp.origem.scopus2-s2.0-84955451520
hcfmusp.origem.wosWOS:000368819700004
hcfmusp.publisher.cityAMSTERDAM
hcfmusp.publisher.countryNETHERLANDS
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