Effects of different diet intake and resistance training on left ventricle remodeling in ovariectomized rats

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article
Data de publicação
2019
DOI
Scopus
Título da Revista
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SPRINGER LONDON
Autores
CURY, J.C.S.
ENCINAS, J. de Araújo
ORNELAS, E. de Marco
LIMA, N.E.A. de
BRAGGION, G.F.
ALVES, B. da Costa Aguiar
VEIGA, G.L. da
FONSECA, F.L.A.
MAIFRINO, L.B.M.
Citação
COMPARATIVE CLINICAL PATHOLOGY, v.28, n.6, p.1797-1803, 2019
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Resumo
It is known that physical activity promotes positive physiological adaptations, especially in cardiovascular responses in individuals of different age groups; however, it is necessary to know if different diet influences the effects of exercise on the left ventricular remodeling. Its aim is to evaluate the effects of resistance training associated with vegetable and animal protein diets on the left ventricular remodeling of ovariectomized aged animals. Female Wistar rats were divided into eight experimental groups: sedentary and non-ovariectomized animals plus vegetable protein diet (CVS) or animal protein diet (CAS); trained and non-ovariectomized rats plus vegetable protein diet (CVT) or animal protein diet (CAT); sedentary and ovariectomized groups plus vegetable protein diet (VOS) or animal protein diet (AOS); trained and ovariectomized animals plus vegetable protein diet (VOT) or animal protein diet (AOT). Ovariectomy promoted an increase in the density of collagen type I and III in all animals, being more marked in the groups of vegetal protein diet (p < 0.05). Additionally, our ultrastructural analysis demonstrated a greater amount of type I collagen fibers and a decrease of type III collagen fibers in the sedentary ovariectomized animals regardless of the diet consumed. We can observe that VOT and AOT had a significant decrease (p < 0.05) of MMP-2 when compared to the other groups. In addition, both training and/or ovariectomized groups demonstrated an increase in MMP-9. We observed the benefits of resistance training associated mainly with the animal diet on cardiac tissue, highlighting the importance of these interventions in the prevention and reversal of changes in the various organs and systems resulting from menopause. © 2019, Springer-Verlag London Ltd., part of Springer Nature.
Palavras-chave
Aging, Animals, Exercise, Menopause, Myocardium
URI
https://observatorio.fm.usp.br/handle/OPI/35755
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Coleções
Artigos e Materiais de Revistas Científicas - LIM/66