Prevalence, awareness, treatment, and control, of high low-density lipoprotein cholesterol in Brazil: Baseline of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorLOTUFO, Paulo A.
dc.contributor.authorSANTOS, Raul D.
dc.contributor.authorFIGUEIREDO, Roberta M.
dc.contributor.authorPEREIRA, Alexandre C.
dc.contributor.authorMILL, Jose Geraldo
dc.contributor.authorALVIM, Sheila M.
dc.contributor.authorFONSECA, M. Jesus
dc.contributor.authorALMEIDA, M. Conceicao
dc.contributor.authorMOLINA, M. Carmen
dc.contributor.authorCHOR, Dora
dc.contributor.authorSCHMIDT, Maria Ines
dc.contributor.authorRIBEIRO, Antonio L.
dc.contributor.authorDUNCAN, Bruce B.
dc.contributor.authorBENSENOR, Isabela M.
dc.date.accessioned2016-07-18T11:40:54Z
dc.date.available2016-07-18T11:40:54Z
dc.date.issued2016
dc.description.abstractBACKGROUND AND OBJECTIVES: Dyslipidemia is a pivotal risk factor for coronary heart disease (CHD). The purpose of this study was to identify the profile of dyslipidemia in a Brazilian population, according to high low-density lipoprotein (LDL-C) levels. We used the classification of the 2004 update of National Cholesterol Education Program Adult Treatment Panel III (ATP-III). METHODS: Of the 15,105 men and women aged 35 to 74 years enrolled in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil), we included 14,648 subjects (97%). They had data to categorize them according to the NCEP-ATP-III criteria. We compared 4 categories: ""0-1"" risk factors, ""2 or more risk factors"", ""CHD or CHD risk equivalent"", and ""CHD at very high risk"". The sociodemographic determinants used were sex, age, ethnicity, income, education, and health insurance. Poisson regression was used to estimate the prevalence ratios for cholesterol (LDL-C), frequency, awareness, treatment, and control of high LDL-C. RESULTS: The frequencies of high LDL-C, awareness, treatment, and control were 45.5%, 58.1%, 42.3%, and 58.3%, respectively. After adjustment for sociodemographic determinants, the prevalence ratios for high LDL-C were significantly higher for men, blacks, older subjects, and subjects with lower levels of education. Low frequency of awareness, treatment, and uncontrolled values of LDL-C was observed among men, mixed race and blacks, poorer, less educated, and those who did not have private health insurance. CONCLUSIONS: The prevalence of high LDL-C was elevated in this Brazilian population, with low rates of awareness, treatment and control, and remarkable socioeconomic disparity.
dc.description.indexMEDLINE
dc.description.sponsorshipBrazilian Ministry of Health (Science and Technology Department)
dc.description.sponsorshipBrazilian Ministry of Science and Technology (Financiadora de Estudos e Projetos) [01 06 0010.00 RS, 01 06 0212.00 BA, 01 06 0300.00 ES, 01 06 0278.00 MG, 01 06 0115.00 SP, 01 06 0071.00 RJ]
dc.description.sponsorshipBrazilian Ministry of Science and Technology (CNPq National Research Council) [01 06 0010.00 RS, 01 06 0212.00 BA, 01 06 0300.00 ES, 01 06 0278.00 MG, 01 06 0115.00 SP, 01 06 0071.00 RJ]
dc.identifier.citationJOURNAL OF CLINICAL LIPIDOLOGY, v.10, n.3, p.568-576, 2016
dc.identifier.doi10.1016/j.jacl.2015.12.029
dc.identifier.eissn1876-4789
dc.identifier.issn1933-2874
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/14159
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INC
dc.relation.ispartofJournal of Clinical Lipidology
dc.rightsrestrictedAccess
dc.rights.holderCopyright ELSEVIER SCIENCE INC
dc.subjectDyslipidemia
dc.subjectStatins
dc.subjectCoronary heart disease
dc.subjectEpidemiology
dc.subjectRisk factors
dc.subjectCardiovascular
dc.subject.othertreatment panel iii
dc.subject.otherrisk-factors
dc.subject.othernational-health
dc.subject.otherunited-states
dc.subject.otherdyslipidemia
dc.subject.otherhypercholesterolemia
dc.subject.otheratherosclerosis
dc.subject.otherdisease
dc.subject.otherhypertension
dc.subject.otherprevention
dc.subject.wosPharmacology & Pharmacy
dc.titlePrevalence, awareness, treatment, and control, of high low-density lipoprotein cholesterol in Brazil: Baseline of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalFIGUEIREDO, Roberta M.:Fed Univ S Joao DelRei, Sao Joao Delrei, Brazil; Univ Fed Minas Gerais, Belo Horizonte, MG, Brazil
hcfmusp.author.externalMILL, Jose Geraldo:Univ Fed Espirito Santo, Vitoria, Brazil
hcfmusp.author.externalALVIM, Sheila M.:Univ Fed Bahia, Salvador, BA, Brazil
hcfmusp.author.externalFONSECA, M. Jesus:Fundacao Oswaldo Cruz, Rio De Janeiro, Brazil
hcfmusp.author.externalALMEIDA, M. Conceicao:Univ Fed Bahia, Salvador, BA, Brazil
hcfmusp.author.externalMOLINA, M. Carmen:Univ Fed Espirito Santo, Vitoria, Brazil
hcfmusp.author.externalCHOR, Dora:Fundacao Oswaldo Cruz, Rio De Janeiro, Brazil
hcfmusp.author.externalSCHMIDT, Maria Ines:Univ Fed Rio Grande do Sul, Dept Prevent Med, Porto Alegre, Brazil
hcfmusp.author.externalRIBEIRO, Antonio L.:Univ Fed Minas Gerais, Dept Internal Med, Belo Horizonte, MG, Brazil
hcfmusp.author.externalDUNCAN, Bruce B.:Univ Fed Rio Grande do Sul, Dept Prevent Med, Porto Alegre, Brazil
hcfmusp.citation.scopus32
hcfmusp.contributor.author-fmusphcPAULO ANDRADE LOTUFO
hcfmusp.contributor.author-fmusphcRAUL DIAS DOS SANTOS FILHO
hcfmusp.contributor.author-fmusphcALEXANDRE DA COSTA PEREIRA
hcfmusp.contributor.author-fmusphcISABELA JUDITH MARTINS BENSEñOR
hcfmusp.description.beginpage568
hcfmusp.description.endpage576
hcfmusp.description.issue3
hcfmusp.description.volume10
hcfmusp.origemWOS
hcfmusp.origem.pubmed27206944
hcfmusp.origem.scopus2-s2.0-84958260552
hcfmusp.origem.wosWOS:000376218800017
hcfmusp.publisher.cityNEW YORK
hcfmusp.publisher.countryUSA
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