The Relationship Among HOXA10, Estrogen Receptor alpha, Progesterone Receptor, and Progesterone Receptor B Proteins in Rectosigmoid Endometriosis: A Tissue Microarray Study

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorZANATTA, Alysson
dc.contributor.authorPEREIRA, Ricardo Mendes Alves
dc.contributor.authorROCHA, Andre Monteiro da
dc.contributor.authorCOGLIATI, Bruno
dc.contributor.authorBARACAT, Edmund Chada
dc.contributor.authorTAYLOR, Hugh S.
dc.contributor.authorMOTTA, Eduardo Leme Alves da
dc.contributor.authorSERAFINI, Paulo Cesar
dc.date.accessioned2015-04-22T22:14:04Z
dc.date.available2015-04-22T22:14:04Z
dc.date.issued2015
dc.description.abstractBackground: Very few studies have evaluated the expression of homeobox A10 (HOXA10) and steroid (estrogen and progesterone) receptors exclusively in deep endometriosis. Conclusions drawn from studies evaluating peritoneal and ovarian endometriosis are usually generalized to explain the pathogenesis of the disease as a whole. We aimed to evaluate the expression of HOXA10, estrogen receptor (ER-), progesterone receptor (PR), and PR-B in rectosigmoid endometriosis (RE), a typical model of deep disease. Methods: We used RE samples from 18 consecutive patients to construct tissue microarray blocks. Nine patients each were operated during the proliferative and secretory phases of the menstrual cycle. We quantified the expressions of proteins by immunohistochemistry using the modified Allred score. Result: The HOXA10 was expressed in the stroma of nodules during the secretory phase in 5 of the 18 patients. Expression of ER- (in 16 of 18 patients), PR (in 17 of 18 patients), and PR-B (17 of 18 patients) was moderate to strong in the glands and stroma of nodules during both phases. Expression of both PR (P = .023) and PR-B (P = .024) was significantly greater during the secretory phase. Conclusion: The HOXA10 is expressed in RE, where it likely imparts the de novo identity of endometriotic lesions. The ER-, PR, and PR-B are strongly expressed in RE, which differs from previous studies investigating peritoneal and ovarian lesions. This suggests different routes of pathogenesis for each of the 3 types of endometriosis.
dc.description.indexMEDLINE
dc.identifier.citationREPRODUCTIVE SCIENCES, v.22, n.1, p.31-37, 2015
dc.identifier.doi10.1177/1933719114549846
dc.identifier.eissn1933-7205
dc.identifier.issn1933-7191
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/9017
dc.language.isoeng
dc.publisherSAGE PUBLICATIONS INC
dc.relation.ispartofReproductive Sciences
dc.rightsrestrictedAccess
dc.rights.holderCopyright SAGE PUBLICATIONS INC
dc.subjectHOXA10
dc.subjectestrogen receptor
dc.subjectprogesterone receptor
dc.subjectrectosigmoid endometriosis
dc.subjectdeep endometriosis pathogenesis
dc.subject.otherresponse element
dc.subject.otherdiethylstilbestrol des
dc.subject.otherovarian endometriosis
dc.subject.otherhomeobox genes
dc.subject.otherstromal cells
dc.subject.otherexpression
dc.subject.otherbeta
dc.subject.otherdisease
dc.subject.othercancer
dc.subject.otherestablishment
dc.subject.wosObstetrics & Gynecology
dc.subject.wosReproductive Biology
dc.titleThe Relationship Among HOXA10, Estrogen Receptor alpha, Progesterone Receptor, and Progesterone Receptor B Proteins in Rectosigmoid Endometriosis: A Tissue Microarray Study
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryisous
hcfmusp.author.externalPEREIRA, Ricardo Mendes Alves:Santa Joana Hosp, Endometriosis Ctr, Sao Paulo, Brazil
hcfmusp.author.externalROCHA, Andre Monteiro da:Univ Michigan, Dept Obstet & Gynecol, Ann Arbor, MI 48109 USA
hcfmusp.author.externalCOGLIATI, Bruno:Univ Sao Paulo, Sch Zootechny & Vet Med, Dept Mol & Morphol Sci, Sao Paulo, Brazil
hcfmusp.author.externalTAYLOR, Hugh S.:Yale Univ, Sch Med, Dept Obstet Gynecol & Reprod Sci, New Haven, CT USA
hcfmusp.author.externalMOTTA, Eduardo Leme Alves da:Sao Paulo Fed Univ, Sch Med, Dept Gynecol, Sao Paulo, Brazil
hcfmusp.citation.scopus49
hcfmusp.contributor.author-fmusphcALYSSON ZANATTA
hcfmusp.contributor.author-fmusphcEDMUND CHADA BARACAT
hcfmusp.contributor.author-fmusphcPAULO CESAR SERAFINI
hcfmusp.description.beginpage31
hcfmusp.description.endpage37
hcfmusp.description.issue1
hcfmusp.description.volume22
hcfmusp.origemWOS
hcfmusp.origem.pubmed25217304
hcfmusp.origem.scopus2-s2.0-84919684036
hcfmusp.origem.wosWOS:000346642600005
hcfmusp.publisher.cityTHOUSAND OAKS
hcfmusp.publisher.countryUSA
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