A Consensus Statement on acromegaly therapeutic outcomes

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorMELMED, Shlomo
dc.contributor.authorBRONSTEIN, Marcello D.
dc.contributor.authorCHANSON, Philippe
dc.contributor.authorKLIBANSKI, Anne
dc.contributor.authorCASANUEVA, Felipe F.
dc.contributor.authorWASS, John A. H.
dc.contributor.authorSTRASBURGER, Christian J.
dc.contributor.authorLUGER, Anton
dc.contributor.authorCLEMMONS, David R.
dc.contributor.authorGIUSTINA, Andrea
dc.date.accessioned2018-09-13T15:27:42Z
dc.date.available2018-09-13T15:27:42Z
dc.date.issued2018
dc.description.abstractThe 11th Acromegaly Consensus Conference in April 2017 was convened to update recommendations on therapeutic outcomes for patients with acromegaly. Consensus guidelines on the medical management of acromegaly were last published in 2014; since then, new pharmacological agents have been developed and new approaches to treatment sequencing have been considered. Thirty-seven experts in the management of patients with acromegaly reviewed the current literature and assessed changes in drug approvals, clinical practice standards and clinical opinion. They considered current treatment outcome goals with a focus on the impact of current and emerging somatostatin receptor ligands, growth hormone receptor antagonists and dopamine agonists on biochemical, clinical, tumour mass and surgical outcomes. The participants discussed factors that would determine pharmacological choices as well as the proposed place of each agent in the guidelines. We present consensus recommendations highlighting how acromegaly management could be optimized in clinical practice.
dc.description.indexMEDLINE
dc.description.sponsorshipIpsen Ltd
dc.description.sponsorshipNovartis Pharmaceuticals
dc.description.sponsorshipPfizer
dc.description.sponsorshipCedars-Sinai Medical Center, Los Angeles, CA, USA
dc.identifier.citationNATURE REVIEWS ENDOCRINOLOGY, v.14, n.9, p.552-561, 2018
dc.identifier.doi10.1038/s41574-018-0058-5
dc.identifier.eissn1759-5037
dc.identifier.issn1759-5029
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/28347
dc.language.isoeng
dc.publisherNATURE PUBLISHING GROUP
dc.relation.ispartofNature Reviews Endocrinology
dc.rightsopenAccess
dc.rights.holderCopyright NATURE PUBLISHING GROUP
dc.subject.otheracting somatostatin analogs
dc.subject.othergrowth-factor-i
dc.subject.otherendoscopic transsphenoidal surgery
dc.subject.otherreceptor antagonist pegvisomant
dc.subject.othercardiovascular risk-factors
dc.subject.otherbone-mineral density
dc.subject.otherlong-term treatment
dc.subject.otherpituitary-adenomas
dc.subject.otherfollow-up
dc.subject.otherglucose-tolerance
dc.subject.wosEndocrinology & Metabolism
dc.titleA Consensus Statement on acromegaly therapeutic outcomes
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryÁustria
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryFrança
hcfmusp.affiliation.countryEspanha
hcfmusp.affiliation.countryInglaterra
hcfmusp.affiliation.countryAlemanha
hcfmusp.affiliation.countryItália
hcfmusp.affiliation.countryisous
hcfmusp.affiliation.countryisofr
hcfmusp.affiliation.countryisoes
hcfmusp.affiliation.countryisogb
hcfmusp.affiliation.countryisode
hcfmusp.affiliation.countryisoat
hcfmusp.affiliation.countryisoit
hcfmusp.author.externalMELMED, Shlomo:Cedars Sinai Med Ctr, Dept Med, Los Angeles, CA 90048 USA
hcfmusp.author.externalCHANSON, Philippe:Hop Bicetre, AP HP, Serv Endocrinol & Malad Reprod, Ctr Reference Malad Rares Hypophyse, Paris, France; Univ Paris Sud, Univ Paris Saclay, Fac Med Paris Sud, UMR S 1185, Paris, France
hcfmusp.author.externalKLIBANSKI, Anne:Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA
hcfmusp.author.externalCASANUEVA, Felipe F.:Santiago de Compostela Univ, Dept Med, Santiago De Compostela, Spain
hcfmusp.author.externalWASS, John A. H.:Churchill Hosp, Dept Endocrinol, Oxford, England
hcfmusp.author.externalSTRASBURGER, Christian J.:Charite Univ Med Campus Mitte, Dept Med, Berlin, Germany
hcfmusp.author.externalLUGER, Anton:Med Univ Vienna, Div Endocrinol & Metab, Vienna, Austria
hcfmusp.author.externalCLEMMONS, David R.:Univ N Carolina, Dept Med, Chapel Hill, NC 27515 USA
hcfmusp.author.externalGIUSTINA, Andrea:San Raffaele Univ Hosp Milan, Dept Endocrinol & Metab, Milan, Italy
hcfmusp.citation.scopus393
hcfmusp.contributor.author-fmusphcMARCELLO DELANO BRONSTEIN
hcfmusp.description.beginpage552
hcfmusp.description.endpage561
hcfmusp.description.issue9
hcfmusp.description.volume14
hcfmusp.origemWOS
hcfmusp.origem.pubmed30050156
hcfmusp.origem.scopus2-s2.0-85050657303
hcfmusp.origem.wosWOS:000441297600017
hcfmusp.publisher.cityNEW YORK
hcfmusp.publisher.countryUSA
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