IMPACT OF TIME ON FLUID RESUSCITATION WITH HYPERTONIC SALINE (NACL 7.5%) IN RATS WITH LPS-INDUCED ACUTE LUNG INJURY

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorPETRONI, Ricardo Costa
dc.contributor.authorBISELLI, Paolo Jose Cesare
dc.contributor.authorLIMA, Thais Martins de
dc.contributor.authorVELASCO, Irineu Tadeu
dc.contributor.authorSORIANO, Francisco Garcia
dc.date.accessioned2016-02-11T14:04:21Z
dc.date.available2016-02-11T14:04:21Z
dc.date.issued2015
dc.description.abstractAcute lung injury (ALI) is a common complication associated with septic shock that directly influences the prognosis of sepsis patients. Currently, one of the main supportive treatment modalities for septic shock is fluid resuscitation. The use of hypertonic saline (HS: 7.5% NaCl) for fluid resuscitation has been described as a promising therapy in experimental models of sepsis-induced ALI, but it has failed to produce similar results in clinical practice. Thus, we compared experimental timing versus clinical timing effectiveness (i.e., early vs. late fluid resuscitation) after the inflammatory scenario was established in a rat model of bacterial lipopolysaccharide-induced ALI. We found that late fluid resuscitation with hypertonic saline (NaCl 7.5%) did not reduce the mortality rates of animals compared with the mortality late associated with early treatment. Late fluid resuscitation with both hypertonic and normal saline increased pulmonary inflammation, decreased pulmonary function, and induced pulmonary injury by elevating metalloproteinase-2 and metalloproteinase-9 activity and collagen deposition in the animals, unlike early treatment. The animals with lipopolysaccharide-induced ALI that received late resuscitation with any kind of fluids demonstrated aggravated pulmonary injury and respiratory function. Moreover, we showed that the therapeutic window for a beneficial effect of fluid resuscitation with hypertonic saline is very narrow.
dc.description.indexMEDLINE
dc.description.sponsorship[FAPESP-09/03338-7]
dc.description.sponsorship[09/07478-8]
dc.description.sponsorship[CNPq-470744/2004-9]
dc.identifier.citationSHOCK, v.44, n.6, p.609-615, 2015
dc.identifier.doi10.1097/SHK.0000000000000461
dc.identifier.eissn1540-0514
dc.identifier.issn1073-2322
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/12613
dc.language.isoeng
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.relation.ispartofShock
dc.rightsrestrictedAccess
dc.rights.holderCopyright LIPPINCOTT WILLIAMS & WILKINS
dc.subjectAcute lung injury
dc.subjectcytokines
dc.subjectfluid resuscitation
dc.subjectinflammation
dc.subjectsepsis
dc.subject.othernf-kappa-b
dc.subject.otherinflammatory response
dc.subject.otherendotoxemic rats
dc.subject.otherseptic shock
dc.subject.othersepsis
dc.subject.otherexpression
dc.subject.othermodel
dc.subject.othergene
dc.subject.otherpcr
dc.subject.wosCritical Care Medicine
dc.subject.wosHematology
dc.subject.wosSurgery
dc.subject.wosPeripheral Vascular Disease
dc.titleIMPACT OF TIME ON FLUID RESUSCITATION WITH HYPERTONIC SALINE (NACL 7.5%) IN RATS WITH LPS-INDUCED ACUTE LUNG INJURY
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.citation.scopus11
hcfmusp.contributor.author-fmusphcRICARDO COSTA PETRONI
hcfmusp.contributor.author-fmusphcPAOLO JOSE CESARE BISELLI
hcfmusp.contributor.author-fmusphcTHAIS MARTINS DE LIMA
hcfmusp.contributor.author-fmusphcIRINEU TADEU VELASCO
hcfmusp.contributor.author-fmusphcFRANCISCO GARCIA SORIANO
hcfmusp.description.beginpage609
hcfmusp.description.endpage615
hcfmusp.description.issue6
hcfmusp.description.volume44
hcfmusp.origemWOS
hcfmusp.origem.pubmed26529650
hcfmusp.origem.scopus2-s2.0-84947864548
hcfmusp.origem.wosWOS:000365673700014
hcfmusp.publisher.cityPHILADELPHIA
hcfmusp.publisher.countryUSA
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