Bovine-associated staphylococci and mammaliicocci trigger T-lymphocyte proliferative response and cytokine production differently

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSOUZA, Fernando N.
dc.contributor.authorSANTOS, Kamila R.
dc.contributor.authorFERRONATTO, Jose A.
dc.contributor.authorSANCHEZ, Eduardo M. Ramos
dc.contributor.authorTOLEDO-SILVA, Bruno
dc.contributor.authorHEINEMANN, Marcos B.
dc.contributor.authorVLIEGHER, Sarne De
dc.contributor.authorLIBERA, Alice M. M. P. Della
dc.date.accessioned2023-06-21T14:27:25Z
dc.date.available2023-06-21T14:27:25Z
dc.date.issued2023
dc.description.abstractWe examined whether distinct staphylococcal and mammaliicoccal species and strains trigger B-and T-lymphocyte proliferation and interleukin (IL)-17A and interferon (IFN)-gamma production by peripheral blood mononuclear cells in nulliparous, primiparous, and multiparous dairy cows. Flow cytometry was used to measure lymphocyte proliferation with the Ki67 anti-body, and specific monoclonal antibodies were used to identify CD3, CD4, and CD8 T lymphocyte and CD21 B lymphocyte populations. The supernatant of the peripheral blood mononuclear cell culture was used to measure IL-17A and IFN-gamma production. Two distinct, inactivated strains of bovine-associated Staphylococcus aureus [one causing a persistent intramammary infec-tion (IMI) and the other from the nose], 2 inactivated Staphylococcus chromogenes strains [one causing an IMI and the other from a teat apex), as well as an inactivated Mammaliicoccus fleurettii strain originat-ing from sawdust from a dairy farm, and the mitogens concanavalin A and phytohemagglutinin M-form (both specifically to measure lymphocyte proliferation) were studied. In contrast to the ""commensal"" Staph. aureus strain originating from the nose, the Staph. aureus strain causing a persistent IMI triggered proliferation of CD4+ and CD8+ subpopulations of T lymphocytes. The M. fleurettii strain and the 2 Staph. chromogenes strains had no effect on T-or B-cell proliferation. Fur-thermore, both Staph. aureus and Staph. chromogenes strains causing persistent IMI significantly increased IL-17A and IFN-gamma production by peripheral blood mononuclear cells. Overall, multiparous cows tended to have a higher B-lymphocyte and a lower T-lymphocyte proliferative response than primiparous and nulliparous cows. Peripheral blood mononuclear cells of multipa-rous cows also produced significantly more IL-17A and IFN-gamma. In contrast to concanavalin A, phytohemagglu-tinin M-form selectively stimulated T-cell proliferation.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq Project) [423191/2018-7]
dc.description.sponsorshipFAPESP (Sao Paulo, Brazil) [2014/23189-4]
dc.description.sponsorshipNational Council for Scientific and Technological Development (CNPq
dc.description.sponsorshipBrasilia, Brazil)
dc.description.sponsorshipCoordinator for the Improvement of Higher Education Personnel (CAPES
dc.description.sponsorshipBrasilia, Brazil)
dc.identifier.citationJOURNAL OF DAIRY SCIENCE, v.106, n.4, p.2772-2783, 2023
dc.identifier.doi10.3168/jds.2022-22529
dc.identifier.eissn1525-3198
dc.identifier.issn0022-0302
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/54293
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INCeng
dc.relation.ispartofJournal of Dairy Science
dc.rightsopenAccesseng
dc.rights.holderCopyright ELSEVIER SCIENCE INCeng
dc.subjectmastitiseng
dc.subjectStaphylococcus aureuseng
dc.subjectnon-aureus staphylococcieng
dc.subjectMammaliicoccuseng
dc.subjectlymphocyte proliferationeng
dc.subject.othercoagulase-negative staphylococcuseng
dc.subject.othermouse mastitis modeleng
dc.subject.othersomatic-cell counteng
dc.subject.otherintramammary infectioneng
dc.subject.otherearly lactationeng
dc.subject.otherdairy-cowseng
dc.subject.othermilkeng
dc.subject.otheraureuseng
dc.subject.othercapacityeng
dc.subject.otherexpressioneng
dc.subject.wosAgriculture, Dairy & Animal Scienceeng
dc.subject.wosFood Science & Technologyeng
dc.titleBovine-associated staphylococci and mammaliicocci trigger T-lymphocyte proliferative response and cytokine production differentlyeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryBélgica
hcfmusp.affiliation.countryisobe
hcfmusp.author.externalSOUZA, Fernando N.:Univ Sao Paulo, Fac Med Vet & Zootecnia, Dept Clin Med, Vet Clin Immunol Res Grp, Ave Prof Dr Orlando Marques Paiva 87, BR-05508270 Sao Paulo, Brazil; Univ Ghent, Fac Vet Med, Dept Internal Med Reprod & Populat Med, M Team & Mastitis & Milk Qual Res Unit, Salisburylaan 133, B-9820 Merelbeke, Belgium; Univ Fed Paraiba, Programa Posgrad Ciencia Anim, BR-58397000 Areia, Brazil
hcfmusp.author.externalSANTOS, Kamila R.:Univ Sao Paulo, Fac Med Vet & Zootecnia, Dept Clin Med, Vet Clin Immunol Res Grp, Ave Prof Dr Orlando Marques Paiva 87, BR-05508270 Sao Paulo, Brazil
hcfmusp.author.externalFERRONATTO, Jose A.:Univ Sao Paulo, Fac Med Vet & Zootecnia, Dept Clin Med, Vet Clin Immunol Res Grp, Ave Prof Dr Orlando Marques Paiva 87, BR-05508270 Sao Paulo, Brazil
hcfmusp.author.externalTOLEDO-SILVA, Bruno:Univ Ghent, Fac Vet Med, Dept Internal Med Reprod & Populat Med, M Team & Mastitis & Milk Qual Res Unit, Salisburylaan 133, B-9820 Merelbeke, Belgium
hcfmusp.author.externalHEINEMANN, Marcos B.:Univ Sao Paulo, Fac Med Vet & Zootecnia, Dept Med Vet Prevent & Saude Anim, BR-05508270 Sao Paulo, Brazil
hcfmusp.author.externalVLIEGHER, Sarne De:Univ Ghent, Fac Vet Med, Dept Internal Med Reprod & Populat Med, M Team & Mastitis & Milk Qual Res Unit, Salisburylaan 133, B-9820 Merelbeke, Belgium
hcfmusp.author.externalLIBERA, Alice M. M. P. Della:Univ Sao Paulo, Fac Med Vet & Zootecnia, Dept Clin Med, Vet Clin Immunol Res Grp, Ave Prof Dr Orlando Marques Paiva 87, BR-05508270 Sao Paulo, Brazil
hcfmusp.citation.scopus3
hcfmusp.contributor.author-fmusphcEDUARDO MILTON RAMOS SANCHEZ
hcfmusp.description.beginpage2772
hcfmusp.description.endpage2783
hcfmusp.description.issue4
hcfmusp.description.volume106
hcfmusp.origemWOS
hcfmusp.origem.pubmed36870844
hcfmusp.origem.scopus2-s2.0-85149630020
hcfmusp.origem.wosWOS:000973793700001
hcfmusp.publisher.cityNEW YORKeng
hcfmusp.publisher.countryUSAeng
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