Comparative long-term study between two dermal regeneration templates for the reconstruction of burn scar contractures in humans: Clinical and histological results

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorVANA, Luiz Philipe Molina
dc.contributor.authorBATTLEHNER, Claudia Naves
dc.contributor.authorFERREIRA, Marcelo Alves
dc.contributor.authorCALDINI, Elia Garcia
dc.contributor.authorGEMPERLI, Rolf
dc.contributor.authorALONSO, Nivaldo
dc.date.accessioned2020-06-01T14:58:39Z
dc.date.available2020-06-01T14:58:39Z
dc.date.issued2020
dc.description.abstractThe advent of dermal regeneration templates has fostered major advances in the treatment of acute bums and their sequelae, in the last three decades. Both data on morphological aspects of the newly-formed tissue, and clinical trials comparing different templates, are few. The goal of this study was to prospectively analyze the outcome of randomized patients treated with two of the existing templates, followed by thin skin autograft. They are both 2mm-thick bovine collagen templates (Matriderm (R) and Integra (R)), the latter includes a superficial silicone layer. Surgery was performed on patients with impaired mobility resulting from bum sequelae (n =12 per template) in a two-step procedure. Negative pressure therapy was applied after surgery; patients were monitored for 12 months. No infra or postoperative complications were observed. Data on scar skin quality (Vancouver scar scale), rate of mobility recovery, and graft contraction were recorded; as well as morphological analyses at light microscopical level. Improvement in mobility and skin quality were demonstrated along with graft contraction, in all patients. The double layer template showed the best performance in retraction rate, skin quality and mobility recovery. The subepidermal newly-formed connective tissue showed no histoarchitectural differences between the templates. The double layer template was not absorbed up to 12 months after placement.eng
dc.description.indexMEDLINEeng
dc.identifier.citationBURNS, v.46, n.3, p.596-608, 2020
dc.identifier.doi10.1016/j.burns.2019.09.005
dc.identifier.eissn1879-1409
dc.identifier.issn0305-4179
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/36075
dc.language.isoeng
dc.publisherELSEVIER SCI LTDeng
dc.relation.ispartofBurns
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright ELSEVIER SCI LTDeng
dc.subjectNegative-pressure wound therapyeng
dc.subjectDermal regeneration templateeng
dc.subjectArtificial skineng
dc.subjectIntegraeng
dc.subjectMatridermeng
dc.subject.othernegative-pressure therapyeng
dc.subject.otherintegra artificial skineng
dc.subject.otherinterrater reliabilityeng
dc.subject.otherwound therapyeng
dc.subject.otherthicknesseng
dc.subject.othersubstituteseng
dc.subject.otherdefectseng
dc.subject.othersurgeryeng
dc.subject.otherpatienteng
dc.subject.otherdesigneng
dc.subject.wosCritical Care Medicineeng
dc.subject.wosDermatologyeng
dc.subject.wosSurgeryeng
dc.titleComparative long-term study between two dermal regeneration templates for the reconstruction of burn scar contractures in humans: Clinical and histological resultseng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.citation.scopus14
hcfmusp.contributor.author-fmusphcLUIZ PHILIPE MOLINA VANA
hcfmusp.contributor.author-fmusphcCLAUDIA NAVES BATTLEHNER
hcfmusp.contributor.author-fmusphcMARCELO ALVES FERREIRA
hcfmusp.contributor.author-fmusphcELIA TAMASO ESPIN GARCIA CALZOLARI
hcfmusp.contributor.author-fmusphcROLF GEMPERLI
hcfmusp.contributor.author-fmusphcNIVALDO ALONSO
hcfmusp.description.beginpage596
hcfmusp.description.endpage608
hcfmusp.description.issue3
hcfmusp.description.volume46
hcfmusp.origemWOS
hcfmusp.origem.pubmed31645293
hcfmusp.origem.scopus2-s2.0-85073823509
hcfmusp.origem.wosWOS:000530707800012
hcfmusp.publisher.cityOXFORDeng
hcfmusp.publisher.countryENGLANDeng
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