The Immunometabolic Roles of Various Fatty Acids in Macrophages and Lymphocytes

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorNETO, Jose Cesar Rosa
dc.contributor.authorCALDER, Philip C.
dc.contributor.authorCURI, Rui
dc.contributor.authorNEWSHOLME, Philip
dc.contributor.authorSETHI, Jaswinder K.
dc.contributor.authorSILVEIRA, Loreana S.
dc.date.accessioned2021-10-20T14:08:04Z
dc.date.available2021-10-20T14:08:04Z
dc.date.issued2021
dc.description.abstractMacrophages and lymphocytes demonstrate metabolic plasticity, which is dependent partly on their state of activation and partly on the availability of various energy yielding and biosynthetic substrates (fatty acids, glucose, and amino acids). These substrates are essential to fuel-based metabolic reprogramming that supports optimal immune function, including the inflammatory response. In this review, we will focus on metabolism in macrophages and lymphocytes and discuss the role of fatty acids in governing the phenotype, activation, and functional status of these important cells. We summarize the current understanding of the pathways of fatty acid metabolism and related mechanisms of action and also explore possible new perspectives in this exciting area of research.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipFundacao a Pesquisa do Estado de Sao Paulo (FAPESP)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [FAPESP: 2019/09679-2, FAPESP: 2019/09854-9]
dc.identifier.citationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.22, n.16, article ID 8460, 16p, 2021
dc.identifier.doi10.3390/ijms22168460
dc.identifier.eissn1422-0067
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/42614
dc.language.isoeng
dc.publisherMDPIeng
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.rightsopenAccesseng
dc.rights.holderCopyright MDPIeng
dc.subjectimmune cellseng
dc.subjectlipidseng
dc.subjectfatty acidseng
dc.subjectmetabolismeng
dc.subjectleukocyteseng
dc.subjectmacrophageseng
dc.subjectlymphocyteseng
dc.subjectinflammationeng
dc.subjectcytokineseng
dc.subject.othert-cell memoryeng
dc.subject.othernf-kappa-beng
dc.subject.othermetabolic-regulationeng
dc.subject.otherperipheral-bloodeng
dc.subject.otherglucose-metabolismeng
dc.subject.otherppar-gammaeng
dc.subject.otherinflammationeng
dc.subject.otherobeseeng
dc.subject.otheractivationeng
dc.subject.otherexpressioneng
dc.subject.wosBiochemistry & Molecular Biologyeng
dc.subject.wosChemistry, Multidisciplinaryeng
dc.titleThe Immunometabolic Roles of Various Fatty Acids in Macrophages and Lymphocyteseng
dc.typearticleeng
dc.type.categoryrevieweng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryAustrália
hcfmusp.affiliation.countryInglaterra
hcfmusp.affiliation.countryisogb
hcfmusp.affiliation.countryisoau
hcfmusp.author.externalCALDER, Philip C.:Univ Southampton, Fac Med, Sch Human Dev & Hlth, Southampton SO16 6YD, Hants, England; Univ Southampton, Natl Inst Hlth Res Southampton Biomed Res Ctr, Southampton SO16 6YD, Hants, England; Univ Hosp Southampton Natl Hlth Serv NHS Fdn Trus, Southampton SO16 6YD, Hants, England; Univ Southampton, Inst Life Sci, Southampton SO17 1BJ, Hants, England
hcfmusp.author.externalCURI, Rui:Univ Cruzeiro Sul, Interdisciplinary Postgrad Program Hlth Sci, BR-01506000 Sao Paulo, Brazil
hcfmusp.author.externalNEWSHOLME, Philip:Curtin Univ, Curtin Med Sch, Perth, WA 6102, Australia; Curtin Univ, Curtin Hlth Innovat Res Inst, Perth, WA 6102, Australia
hcfmusp.author.externalSETHI, Jaswinder K.:Univ Southampton, Fac Med, Sch Human Dev & Hlth, Southampton SO16 6YD, Hants, England; Univ Southampton, Natl Inst Hlth Res Southampton Biomed Res Ctr, Southampton SO16 6YD, Hants, England; Univ Hosp Southampton Natl Hlth Serv NHS Fdn Trus, Southampton SO16 6YD, Hants, England; Univ Southampton, Inst Life Sci, Southampton SO17 1BJ, Hants, England
hcfmusp.author.externalSILVEIRA, Loreana S.:Univ Sao Paulo, Inst Biomed Sci, Dept Cell Biol & Dev, Immunometab Res Grp, BR-05508000 Sao Paulo, Brazil
hcfmusp.citation.scopus17
hcfmusp.contributor.author-fmusphcJOSE CESAR ROSA NETO
hcfmusp.description.articlenumber8460
hcfmusp.description.issue16
hcfmusp.description.volume22
hcfmusp.origemWOS
hcfmusp.origem.pubmed34445165
hcfmusp.origem.scopus2-s2.0-85111910657
hcfmusp.origem.wosWOS:000689317300001
hcfmusp.publisher.cityBASELeng
hcfmusp.publisher.countrySWITZERLANDeng
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