Pemphigus foliaceus, var. Herpetiformis and Sulphonamide

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorAOKI, V.
dc.contributor.authorMIYAMOTO, D.
dc.date.accessioned2023-02-09T19:57:06Z
dc.date.available2023-02-09T19:57:06Z
dc.date.issued2015
dc.description.abstractA 43-year-old woman presented a 2-year history of tender blisters and erythematous and crusted excoriations on the face, trunk and proximal extremities. During her first examination in 1995, erosions and yellow crusts on her face, thorax, upper torso and proximal limbs were present, without mucosal involvement. Laboratory profile confirmed the diagnosis of pemphigus foliaceus, as follows: histopathological analysis exhibited subcorneal abscess with mild spongiosis and scanty acantholytic cells; neutrophilic and linfohystiocitic perivascular infiltrate was present in the superficial dermis; direct immunofluorescence showed intercellular IgG deposits within the entire epidermis; indirect immunofluorescence revealed circulating IgG antibodies (titer=1:1,280) and positive ELISA index (99, recombinant desmoglein 1). Treatment with systemic corticosteroid (prednisone 1 mg/kg/day) was initiated. Clinical remission was achieved after 2 months, followed by gradual corticosteroid tapering. The patient presented reactivation when receiving prednisone 10 mg/day, with vesicles with a herpetiform arrangement on erythematous plaques on her legs, with intense pruritus (Fig. 13.1). © Springer International Publishing Switzerland 2015.
dc.identifier.citationAoki, V.; Miyamoto, D.. Pemphigus foliaceus, var. Herpetiformis and Sulphonamide. In: . CLINICAL CASES IN AUTOIMMUNE BLISTERING DISEASES: SPRINGER INTERNATIONAL PUBLISHING, 2015. p.99-106.
dc.identifier.doi10.1007/978-3-319-10148-4_13
dc.identifier.isbn9783319101484; 9783319101477
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/51093
dc.language.isoeng
dc.publisherSPRINGER INTERNATIONAL PUBLISHING
dc.relation.ispartofCLINICAL CASES IN AUTOIMMUNE BLISTERING DISEASES
dc.rightsrestrictedAccess
dc.rights.holderCopyright SPRINGER INTERNATIONAL PUBLISHING
dc.titlePemphigus foliaceus, var. Herpetiformis and Sulphonamide
dc.typebookPart
dc.type.categorybook chapter
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.citation.scopus0
hcfmusp.contributor.author-fmusphcVALERIA AOKI
hcfmusp.contributor.author-fmusphcDENISE MIYAMOTO
hcfmusp.description.beginpage99
hcfmusp.description.endpage106
hcfmusp.origemSCOPUS
hcfmusp.origem.scopus2-s2.0-84955336162
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relation.isAuthorOfPublication.latestForDiscovery39977d9c-4d58-4ad3-9df5-f4625a05e3b3
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