Neurocircuit models of obsessive-compulsive disorder: limitations and future directions for research

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSHEPHARD, Elizabeth
dc.contributor.authorBATISTUZZO, Marcelo C.
dc.contributor.authorHOEXTER, Marcelo Q.
dc.contributor.authorSTERN, Emily R.
dc.contributor.authorZUCCOLO, Pedro F.
dc.contributor.authorOGAWA, Carolina Y.
dc.contributor.authorSILVA, Renata M.
dc.contributor.authorBRUNONI, Andre R.
dc.contributor.authorCOSTA, Daniel L.
dc.contributor.authorDORETTO, Victoria
dc.contributor.authorSARAIVA, Leonardo
dc.contributor.authorCAPPI, Carolina
dc.contributor.authorSHAVITT, Roseli G.
dc.contributor.authorSIMPSON, H. Blair
dc.contributor.authorHEUVEL, Odile A. van den
dc.contributor.authorMIGUEL, Euripedes C.
dc.date.accessioned2022-06-20T15:24:16Z
dc.date.available2022-06-20T15:24:16Z
dc.date.issued2022
dc.description.abstractObsessive-compulsive disorder (OCD) is a common psychiatric condition classically characterized by obsessions (recurrent, intrusive and unwanted thoughts) and compulsions (excessive, repetitive and ritualistic behaviors or mental acts). OCD is heterogeneous in its clinical presentation and not all patients respond to first-line treatments. Several neurocircuit models of OCD have been proposed with the aim of providing a better understanding of the neural and cognitive mechanisms involved in the disorder. These models use advances in neuroscience and findings from neuropsychological and neuroimaging studies to suggest links between clinical profiles that reflect the symptoms and experiences of patients and dysfunctions in specific neurocircuits. Several models propose that treatments for OCD could be improved if directed to specific neurocircuit dysfunctions, thereby restoring efficient neurocognitive function and ameliorating the symptomatology of each associated clinical profile. Yet, there are several important limitations to neurocircuit models of OCD. The purpose of the current review is to highlight some of these limitations, including issues related to the complexity of brain and cognitive function, the clinical presentation and course of OCD, etiological factors, and treatment methods proposed by the models. We also provide suggestions for future research to advance neurocircuit models of OCD and facilitate translation to clinical application.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [18/22396-7]
dc.description.sponsorshipFAPESP [2014/50917-0]
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [465550/2014-2]
dc.description.sponsorshipInstituto Nacional de Psiquiatria do Desenvolvimento para Criancas e Adolescentes (INDP)
dc.identifier.citationBRAZILIAN JOURNAL OF PSYCHIATRY, v.44, n.2, p.187-200, 2022
dc.identifier.doi10.1590/1516-4446-2020-1709
dc.identifier.eissn1809-452X
dc.identifier.issn1516-4446
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/47020
dc.language.isoeng
dc.publisherASSOC BRASILEIRA PSIQUIATRIAeng
dc.relation.ispartofBrazilian Journal of Psychiatry
dc.rightsopenAccesseng
dc.rights.holderCopyright ASSOC BRASILEIRA PSIQUIATRIAeng
dc.subjectObsessive-compulsive disordereng
dc.subjectclinical presentationeng
dc.subjectneurocircuit modelseng
dc.subjectneurobiologyeng
dc.subjecttreatment advanceseng
dc.subject.other2-year follow-upeng
dc.subject.otherchildhood traumaeng
dc.subject.otherearly-onseteng
dc.subject.othersymptom dimensionseng
dc.subject.otherresponse conflicteng
dc.subject.othersensory phenomenaeng
dc.subject.otherneural synchronyeng
dc.subject.otheradult patientseng
dc.subject.otherconnectivityeng
dc.subject.otherstimulationeng
dc.subject.wosVirologyeng
dc.titleNeurocircuit models of obsessive-compulsive disorder: limitations and future directions for researcheng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryHolanda
hcfmusp.affiliation.countryisous
hcfmusp.affiliation.countryisonl
hcfmusp.author.externalSTERN, Emily R.:NYU, Sch Med, Dept Psychiat, New York, NY USA; Nathan S Kline Inst Psychiat Res, New York, NY USA
hcfmusp.author.externalSIMPSON, H. Blair:Columbia Univ, New York State Psychiat Inst, Ctr OCD & Related Disorders, Irving Med Ctr CUIMC, New York, NY USA; CUIMC, Dept Psychiat, New York, NY USA
hcfmusp.author.externalHEUVEL, Odile A. van den:Vrije Univ Amsterdam, Dept Psychiat, Amsterdam UMC, Amsterdam, Netherlands
hcfmusp.citation.scopus10
hcfmusp.contributor.author-fmusphcELIZABETH SHEPHARD
hcfmusp.contributor.author-fmusphcMARCELO CAMARGO BATISTUZZO
hcfmusp.contributor.author-fmusphcMARCELO QUEIROZ HOEXTER
hcfmusp.contributor.author-fmusphcPEDRO FONSECA ZUCCOLO
hcfmusp.contributor.author-fmusphcCAROLINA YURI OGAWA
hcfmusp.contributor.author-fmusphcRENATA DE MELO FELIPE DA SILVA
hcfmusp.contributor.author-fmusphcANDRE RUSSOWSKY BRUNONI
hcfmusp.contributor.author-fmusphcDANIEL LUCAS DA CONCEICAO COSTA
hcfmusp.contributor.author-fmusphcVICTORIA FOGACA DORETTO
hcfmusp.contributor.author-fmusphcLEONARDO CARDOSO SARAIVA
hcfmusp.contributor.author-fmusphcCAROLINA CAPPI
hcfmusp.contributor.author-fmusphcROSELI GEDANKE SHAVITT
hcfmusp.contributor.author-fmusphcEURIPEDES CONSTANTINO MIGUEL FILHO
hcfmusp.description.beginpage187
hcfmusp.description.endpage200
hcfmusp.description.issue2
hcfmusp.description.volume44
hcfmusp.origemWOS
hcfmusp.origem.pubmed35617698
hcfmusp.origem.scieloSCIELO:S1516-44462022000200187
hcfmusp.origem.scopus2-s2.0-85130060658
hcfmusp.origem.wosWOS:000796180300012
hcfmusp.publisher.citySAO PAULOeng
hcfmusp.publisher.countryBRAZILeng
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