Genetic analyses of smoking initiation, persistence, quantity, and age-at-onset of regular cigarette use in Brazilian families: the Baependi Heart Study

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorHORIMOTO, Andrea R. V. R.
dc.contributor.authorOLIVEIRA, Camila M.
dc.contributor.authorGIOLO, Suely R.
dc.contributor.authorSOLER, Julia P.
dc.contributor.authorANDRADE, Mariza de
dc.contributor.authorKRIEGER, Jose E.
dc.contributor.authorPEREIRA, Alexandre C.
dc.date.accessioned2013-07-30T14:34:43Z
dc.date.available2013-07-30T14:34:43Z
dc.date.issued2012
dc.description.abstractBackground: The purpose of this study was to estimate the genetic influences on the initiation of cigarette smoking, the persistence, quantity and age-at-onset of regular cigarette use in Brazilian families. Methods: The data set consisted of 1,694 individuals enrolled in the Baependi Heart Study. The heritability and the heterogeneity in genetic and environmental variance components by gender were estimated from variance components approaches, using the SOLAR (Sequential Oligogenic Linkage Analysis Routines) computer package. The mixed-effects Cox model was used for the genetic analysis of the age-at onset of regular cigarette use. Results: The heritability estimates were high (> 50%) for smoking initiation and were intermediate, ranging from 23.4 to 31.9%, for smoking persistence and quantity. Significant evidence for heterogeneity in variance components by gender was observed for smoking initiation and age-at-onset of regular cigarette use. Genetic factors play an important role in the interindividual variation of these phenotypes in females, while in males there is a predominant environmental component, which could be explained by greater social influences in the initiation of tobacco use. Conclusions: Significant heritabilities were observed in smoking phenotypes for both males and females from the Brazilian population. These data add to the literature and are concordant with the notion of significant biological determination in smoking behavior. Samples from the Baependi Heart Study may be valuable for the mapping of genetic loci that modulate this complex biological trait.
dc.description.indexMEDLINE
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP) [2010/51010-8, 2007/58150-7]
dc.description.sponsorshipHospital Samaritano, Sao Paulo
dc.description.sponsorshipU.S. Public Health Service from the National Center for Research Resources [RR03655]
dc.identifier.citationBMC MEDICAL GENETICS, v.13, article ID 9, 8p, 2012
dc.identifier.doi10.1186/1471-2350-13-9
dc.identifier.issn1471-2350
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/142
dc.language.isoeng
dc.publisherBIOMED CENTRAL LTD
dc.relation.ispartofBMC Medical Genetics
dc.rightsopenAccess
dc.rights.holderCopyright BIOMED CENTRAL LTD
dc.subject.othercardiovascular risk-factors
dc.subject.othernicotine dependence
dc.subject.othergenome-wide
dc.subject.otheradult twins
dc.subject.othertobacco use
dc.subject.otherbehavior
dc.subject.otherdeterminants
dc.subject.otherheritability
dc.subject.otheralcohol
dc.subject.otherlinkage
dc.subject.wosGenetics & Heredity
dc.titleGenetic analyses of smoking initiation, persistence, quantity, and age-at-onset of regular cigarette use in Brazilian families: the Baependi Heart Study
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryisous
hcfmusp.author.externalOLIVEIRA, Camila M.:Univ Sao Paulo, Lab Genet & Mol Cardiol, Inst Heart, Sch Med, BR-05403000 Sao Paulo, Brazil
hcfmusp.author.externalGIOLO, Suely R.:Univ Fed Parana, Dept Stat, Polytech Ctr, BR-81531990 Curitiba, PR, Brazil
hcfmusp.author.externalSOLER, Julia P.:Univ Sao Paulo, Dept Stat, Math & Stat Inst, BR-05508090 Sao Paulo, Brazil
hcfmusp.author.externalANDRADE, Mariza de:Mayo Clin, Dept Hlth Sci Res, Rochester, MN 55905 USA
hcfmusp.citation.scopus18
hcfmusp.contributor.author-fmusphcANDREA ROSELI VANCAN RUSSO HORIMOTO
hcfmusp.contributor.author-fmusphcJOSE EDUARDO KRIEGER
hcfmusp.contributor.author-fmusphcALEXANDRE DA COSTA PEREIRA
hcfmusp.description.articlenumber9
hcfmusp.description.volume13
hcfmusp.lim.ref2012
hcfmusp.origemWOS
hcfmusp.origem.pubmed22289947
hcfmusp.origem.scopus2-s2.0-84856246605
hcfmusp.origem.wosWOS:000301074000001
hcfmusp.publisher.cityLONDON
hcfmusp.publisher.countryENGLAND
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