Molecular mechanisms and pharmacological interventions in the replication cycle of human coronaviruses

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art_SIMABUCO_Molecular_mechanisms_and_pharmacological_interventions_in_the_replication_2021.PDF (2.16 MB)
Citações na Scopus
9
Tipo de produção
article
Data de publicação
2021
DOI
SciELO
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
SOC BRASIL GENETICA
Autores
SIMABUCO, Fernando Moreira
TAMURA, Rodrigo Esaki
PAVAN, Isadora Carolina Betim
VENTURA, Armando Morais
Citação
GENETICS AND MOLECULAR BIOLOGY, v.44, n.1, suppl.1, article ID e20200212, 18p, 2021
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2), as well as SARS-CoV from 2003 along with MERS-CoV from 2012, is a member of the Betacoronavirus genus of the Nidovirales order and is currently the cause of the pandemic called COVID-19 (or Coronavirus disease 2019). COVID-19, which is characterized by cough, fever, fatigue, and severe cases of pneumonia, has affected more than 23 million people worldwide until August 25th, 2020. Here, we present a review of the cellular mechanisms associated with human coronavirus replication, including the unique molecular events related to the replication transcription complex (RTC) of coronaviruses. We also present information regarding the interactions between each viral protein and cellular proteins associated to known host-pathogen implications for the coronavirus biology. Finally, a specific topic addresses the current attempts for pharmacological interventions against COVID-19, highlighting the possible effects of each drug on the molecular events of viral replication. This review intends to aid future studies for a better understanding of the SARS-CoV-2 replication cycle and the development of pharmacological approaches targeting COVID-19.
Palavras-chave
Coronavirus, SARS-CoV-2, COVID-19, viral replication, RNA virus
URI
https://observatorio.fm.usp.br/handle/OPI/39385
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Artigos e Materiais de Revistas Científicas - FM/Outros
Artigos e Materiais de Revistas Científicas - COVID-19
Artigos e Materiais de Revistas Científicas - LIM/24
Artigos e Materiais de Revistas Científicas - ODS/03