Heterotypic trajectories of dimensional psychopathology across the lifespan: the case of youth-onset attention deficit/hyperactivity disorder

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorMANFRO, Arthur Gus
dc.contributor.authorSANTORO, Marcos
dc.contributor.authorPOLANCZYK, Guilherme Vanoni
dc.contributor.authorGADELHA, Ary
dc.contributor.authorPAN, Pedro Mario
dc.contributor.authorBRESSAN, Rodrigo Affonseca
dc.contributor.authorBRIETZKE, Elisa
dc.contributor.authorTALARICO, Fernanda
dc.contributor.authorBELANGERO, Sintia
dc.contributor.authorROHDE, Luis Augusto
dc.contributor.authorSALUM, Giovanni Abrahao
dc.date.accessioned2019-06-26T17:32:04Z
dc.date.available2019-06-26T17:32:04Z
dc.date.issued2019
dc.description.abstractBackground Recent studies have demonstrated the existence of a distinct late-onset attention deficit/hyperactivity disorder (ADHD) trajectory. Our objective is to test if there are distinct ADHD trajectories regarding age of onset from childhood to adolescence and to compare clinical manifestations, cognitive functions and genetic risk for ADHD among distinct longitudinal groups. Method Nine hundred and twenty four children and adolescents from the community participated in the study. We compared clinical, cognitive features and genetic risk among four groups of participants: (a) childhood-limited, (b) youth-onset, (c) childhood-onset with youth persistence, and (d) community comparisons without ADHD. Symptomatic and diagnostic assessments were performed using the Development and Well-Being Behavior Assessment, the Strengths and Difficulties Questionnaire, and the Child Behavior Checklist. Cognitive functions were measured using a battery of standardized tests. Genetic risk for ADHD was calculating using summary statistics from the Psychiatric Genomics Consortium. Results Half of the adolescents (52%) with ADHD had their symptom onset in adolescence. The impairment level of this group in adolescence is similar to the persistent group. Despite not having ADHD, the youth-onset group already presented in childhood more symptoms from other domains of psychopathology, higher shared variance in psychiatric symptomatology (p-factor), school impairment, and executive dysfunctions than community comparisons. Furthermore, the youth-onset group presented lower levels of genetic risk for ADHD compared to other cases. Conclusions A significant proportion of adolescents with ADHD were youth-onset cases and presented similar impairment levels as those cases with early-onset ADHD. The presence of cognitive impairments and higher levels of clinical symptoms in the youth-onset group already at childhood speaks in favor of a heterotypic trajectory of psychopathology suggesting that youth-onset ADHD might be an artificial consequence of categorizing dimensional psychopathology into discrete diagnostic groups.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipFundacao de Amparo a Pesquisa de Sao Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.description.sponsorshipCNPq
dc.description.sponsorshipFAPESP
dc.description.sponsorshipFundacao Maria Cecilia Souto Vidigal (FMCSV)
dc.description.sponsorshipGrand Challenges Canada
dc.description.sponsorshipBill and Melinda Gates Foundation
dc.description.sponsorshipShire
dc.description.sponsorshipJanssenCilag
dc.description.sponsorshipNovartis
dc.description.sponsorshipCAPES
dc.identifier.citationJOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY, v.60, n.5, p.533-544, 2019
dc.identifier.doi10.1111/jcpp.12987
dc.identifier.eissn1469-7610
dc.identifier.issn0021-9630
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/32523
dc.language.isoeng
dc.publisherWILEYeng
dc.relation.ispartofJournal of Child Psychology and Psychiatry
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright WILEYeng
dc.subjectYouth-onseteng
dc.subjectexecutive functioneng
dc.subjectcognitioneng
dc.subjectpolygenic risk scoreseng
dc.subjectp-factoreng
dc.subject.otherpsychiatric-disorderseng
dc.subject.otherpolygenic riskeng
dc.subject.othergenetic riskeng
dc.subject.otherchildhoodeng
dc.subject.otheradhdeng
dc.subject.otheradolescenceeng
dc.subject.otheradulthoodeng
dc.subject.othervalidityeng
dc.subject.othercohorteng
dc.subject.wosPsychology, Developmentaleng
dc.subject.wosPsychiatryeng
dc.subject.wosPsychologyeng
dc.titleHeterotypic trajectories of dimensional psychopathology across the lifespan: the case of youth-onset attention deficit/hyperactivity disordereng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalMANFRO, Arthur Gus:Univ Fed Rio Grande do Sul, Grad Program Psychiat & Behav Sci, Porto Alegre, RS, Brazil; Natl Inst Dev Psychiat Children & Adolescents INC, Sao Paulo, Brazil
hcfmusp.author.externalSANTORO, Marcos:Natl Inst Dev Psychiat Children & Adolescents INC, Sao Paulo, Brazil; Univ Fed Sao Paulo, LiNC Interdisciplinary Lab Clin Neurosci, Sao Paulo, Brazil
hcfmusp.author.externalGADELHA, Ary:Natl Inst Dev Psychiat Children & Adolescents INC, Sao Paulo, Brazil; Univ Fed Sao Paulo, Dept Psychiat, Sao Paulo, Brazil
hcfmusp.author.externalPAN, Pedro Mario:Natl Inst Dev Psychiat Children & Adolescents INC, Sao Paulo, Brazil; Univ Fed Sao Paulo, Dept Psychiat, Sao Paulo, Brazil
hcfmusp.author.externalBRESSAN, Rodrigo Affonseca:Natl Inst Dev Psychiat Children & Adolescents INC, Sao Paulo, Brazil; Univ Fed Sao Paulo, Dept Psychiat, Sao Paulo, Brazil
hcfmusp.author.externalBRIETZKE, Elisa:Natl Inst Dev Psychiat Children & Adolescents INC, Sao Paulo, Brazil; Univ Fed Sao Paulo, Dept Psychiat, Sao Paulo, Brazil
hcfmusp.author.externalTALARICO, Fernanda:Natl Inst Dev Psychiat Children & Adolescents INC, Sao Paulo, Brazil; Univ Fed Sao Paulo, LiNC Interdisciplinary Lab Clin Neurosci, Sao Paulo, Brazil
hcfmusp.author.externalBELANGERO, Sintia:Natl Inst Dev Psychiat Children & Adolescents INC, Sao Paulo, Brazil; Univ Fed Sao Paulo, LiNC Interdisciplinary Lab Clin Neurosci, Sao Paulo, Brazil
hcfmusp.author.externalSALUM, Giovanni Abrahao:Natl Inst Dev Psychiat Children & Adolescents INC, Sao Paulo, Brazil; Univ Fed Rio Grande do Sul, Dept Psychiat, Porto Alegre, RS, Brazil
hcfmusp.citation.scopus17
hcfmusp.contributor.author-fmusphcGUILHERME VANONI POLANCZYK
hcfmusp.contributor.author-fmusphcLUIS AUGUSTO PAIM ROHDE
hcfmusp.description.beginpage533
hcfmusp.description.endpage544
hcfmusp.description.issue5
hcfmusp.description.volume60
hcfmusp.origemWOS
hcfmusp.origem.pubmed30329156
hcfmusp.origem.scopus2-s2.0-85055097834
hcfmusp.origem.wosWOS:000468313500005
hcfmusp.publisher.cityHOBOKENeng
hcfmusp.publisher.countryUSAeng
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