A randomized controlled trial to reduce sedentary time in rheumatoid arthritis: protocol and rationale of the Take a STAND for Health study
dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | |
dc.contributor.author | PINTO, Ana Jessica | |
dc.contributor.author | PECANHA, Tiago | |
dc.contributor.author | MEIRELES, Kamila | |
dc.contributor.author | BENATTI, Fabiana Braga | |
dc.contributor.author | BONFIGLIOLI, Karina | |
dc.contributor.author | PINTO, Ana Lucia de Sa | |
dc.contributor.author | LIMA, Fernanda Rodrigues | |
dc.contributor.author | PEREIRA, Rosa Maria Rodrigues | |
dc.contributor.author | IRIGOYEN, Maria Claudia Costa | |
dc.contributor.author | TURNER, James Edward | |
dc.contributor.author | KIRWAN, John P. | |
dc.contributor.author | OWEN, Neville | |
dc.contributor.author | DUNSTAN, David W. | |
dc.contributor.author | ROSCHEL, Hamilton | |
dc.contributor.author | GUALANO, Bruno | |
dc.date.accessioned | 2020-03-24T14:54:44Z | |
dc.date.available | 2020-03-24T14:54:44Z | |
dc.date.issued | 2020 | |
dc.description.abstract | Background Patients with rheumatoid arthritis spend most of their daily hours in sedentary behavior (sitting), a predisposing factor to poor health-related outcomes and all-cause mortality. Interventions focused on reducing sedentary time could be of novel therapeutic relevance. However, studies addressing this topic remain scarce. We aim to investigate the feasibility and efficacy of a newly developed intervention focused on reducing sedentary time, and potential clinical, physiological, metabolic and molecular effects in rheumatoid arthritis. Methods The Take a STAND for Health study is a 4-month, parallel-group, randomized controlled trial, in which postmenopausal patients with rheumatoid arthritis will set individually tailored, progressive goals to replace their sedentary time with standing and light-intensity activities. Patients will be recruited from the Clinical Hospital (School of Medicine, University of Sao Paulo) and will be assessed at baseline and after a 4-month follow up. Outcomes will include objectively measured sedentary behavior (primary outcome) and physical activity levels, clinical parameters, anthropometric parameters and body composition; aerobic fitness, muscle function, blood pressure, cardiovascular autonomic function, vascular function and structure, health-related quality of life, and food intake. Blood and muscle samples will be collected for assessing potential mechanisms, through targeted and non-targeted approaches. Discussion Findings will be of scientific and clinical relevance with the potential to inform new prescriptions focused on reducing sedentary behavior, a modifiable risk factor that thus far has been overlooked in patients with rheumatoid arthritis. | eng |
dc.description.index | MEDLINE | eng |
dc.description.sponsorship | Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2015/26937-4, 2018/19418-9, 2016/23319-0, 2017/13552-2] | |
dc.description.sponsorship | Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)CAPES | |
dc.description.sponsorship | Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brasil (CAPES)CAPES [001] | |
dc.identifier.citation | TRIALS, v.21, n.1, article ID 171, 13p, 2020 | |
dc.identifier.doi | 10.1186/s13063-020-4104-y | |
dc.identifier.eissn | 1745-6215 | |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/35615 | |
dc.language.iso | eng | |
dc.publisher | BMC | eng |
dc.relation.ispartof | Trials | |
dc.rights | openAccess | eng |
dc.rights.holder | Copyright BMC | eng |
dc.subject | Sitting | eng |
dc.subject | Light-intensity physical activity | eng |
dc.subject | Rheumatic arthritis | eng |
dc.subject.other | cardiovascular-disease risk | eng |
dc.subject.other | physical-activity | eng |
dc.subject.other | sitting time | eng |
dc.subject.other | association | eng |
dc.subject.other | behavior | eng |
dc.subject.other | exercise | eng |
dc.subject.other | fitness | eng |
dc.subject.other | adults | eng |
dc.subject.other | intervention | eng |
dc.subject.other | metaanalysis | eng |
dc.subject.wos | Medicine, Research & Experimental | eng |
dc.title | A randomized controlled trial to reduce sedentary time in rheumatoid arthritis: protocol and rationale of the Take a STAND for Health study | eng |
dc.type | article | eng |
dc.type.category | original article | eng |
dc.type.version | publishedVersion | eng |
dspace.entity.type | Publication | |
hcfmusp.affiliation.country | Austrália | |
hcfmusp.affiliation.country | Estados Unidos | |
hcfmusp.affiliation.country | Inglaterra | |
hcfmusp.affiliation.countryiso | gb | |
hcfmusp.affiliation.countryiso | us | |
hcfmusp.affiliation.countryiso | au | |
hcfmusp.author.external | TURNER, James Edward:Univ Bath, Dept Hlth, Claverton Down Rd, Bath BA2 7AY, Avon, England | |
hcfmusp.author.external | KIRWAN, John P.:Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA | |
hcfmusp.author.external | OWEN, Neville:Baker Heart & Diabet Inst, 99 Commercial Rd, Melbourne, Vic 3004, Australia; Swinburne Univ Technol, Ctr Urban Transit, John St, Melbourne, Vic 3122, Australia | |
hcfmusp.author.external | DUNSTAN, David W.:Baker Heart & Diabet Inst, 99 Commercial Rd, Melbourne, Vic 3004, Australia; Australian Catholic Univ, Mary MacKillop Inst Hlth Res, 215 Spring St, Melbourne, Vic 3000, Australia | |
hcfmusp.citation.scopus | 2 | |
hcfmusp.contributor.author-fmusphc | ANA JESSICA PINTO | |
hcfmusp.contributor.author-fmusphc | TIAGO PECANHA DE OLIVEIRA | |
hcfmusp.contributor.author-fmusphc | KAMILA MEIRELES DOS SANTOS | |
hcfmusp.contributor.author-fmusphc | FABIANA BRAGA BENATTI | |
hcfmusp.contributor.author-fmusphc | KARINA ROSSI BONFIGLIOLI | |
hcfmusp.contributor.author-fmusphc | ANA LUCIA DE SA PINTO | |
hcfmusp.contributor.author-fmusphc | FERNANDA RODRIGUES LIMA | |
hcfmusp.contributor.author-fmusphc | ROSA MARIA RODRIGUES PEREIRA | |
hcfmusp.contributor.author-fmusphc | MARIA CLAUDIA COSTA IRIGOYEN | |
hcfmusp.contributor.author-fmusphc | HAMILTON AUGUSTO ROSCHEL DA SILVA | |
hcfmusp.contributor.author-fmusphc | BRUNO GUALANO | |
hcfmusp.description.articlenumber | 171 | |
hcfmusp.description.issue | 1 | |
hcfmusp.description.volume | 21 | |
hcfmusp.origem | WOS | |
hcfmusp.origem.pubmed | 32051025 | |
hcfmusp.origem.scopus | 2-s2.0-85079335376 | |
hcfmusp.origem.wos | WOS:000515883600001 | |
hcfmusp.publisher.city | LONDON | eng |
hcfmusp.publisher.country | ENGLAND | eng |
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hcfmusp.scopus.lastupdate | 2024-06-09 | |
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