Clinicopathologic correlation of 282 leukocytoclastic vasculitis cases in a tertiary hospital: a focus on direct immunofluorescence findings at the blood vessel wall

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorTAKATU, Caroline Maris
dc.contributor.authorHERINGER, Antonio Pedro Ribeiro
dc.contributor.authorAOKI, Valeria
dc.contributor.authorVALENTE, Neusa Yuriko Sakai
dc.contributor.authorSANCHEZ, Paula Cristina de Faria
dc.contributor.authorCARVALHO, Jozelio Freire de
dc.contributor.authorCRIADO, Paulo Ricardo
dc.date.accessioned2017-06-09T15:32:47Z
dc.date.available2017-06-09T15:32:47Z
dc.date.issued2017
dc.description.abstractThis is the largest direct immunofluorescence (DIF) analysis of patients with histology-proven cutaneous leukocytoclastic vasculitis (LCV). To establish the correlation of deposition of immune complexes at the blood vessel walls with underlying causes and prognosis of LCV, we performed a retrospective study from January 2007 to December 2014. The patients are followed at the Department of Dermatology, Hospital Das Clinicas da Faculdade de Medicina da Universidade de So Paulo, a tertiary hospital at So Paulo, Brazil. We reviewed the data of 282 biopsy-proven LCV cases with DIF performed. For the statistical analysis, we included only patients with positive DIF exclusively in vessel walls (235/282 patients). We planned to find a correlation between the DIF profiles of LCV patients and the epidemiology data, underlying causes and prognosis. Ages ranged from five to 87 years old (yo), median age of 45 and 191/282 (67.73 %) were female individuals. DIF analysis showed positivity in 70.21 % of the samples, and C3 was the most frequent immunoreactant. Immunoglobulin A (IgA) deposition at the blood vessel wall was related to age and absence of autoimmune/inflammatory diseases. Immunoglobulin M (IgM) deposition at the blood vessel wall was related to females, autoimmune/inflammatory disorders, C3 and C4 consumption and antinuclear antibody and anti-SSA/anti-SSB positivity. Immunoglobulin G (IgG) deposition at the blood vessel wall was associated with age and positive ANCA; finally, C3 deposition at the blood vessel wall was associated with hematuria and renal involvement. Systemic involvement was present in 12.5 % cases of LCV patients. C3 deposits, the most frequent finding of this study, were related to renal involvement; IgA deposits to absence of autoimmune or inflammatory diseases; IgM deposition to the presence of autoimmune or inflammatory diseases and IgG deposits were associated with positive ANCA. DIF seems to be an important method to establish the prognosis and underlying etiology of LCV. Characterization of the immune complex at the blood vessel wall by DIF is relevant to determine underlying conditions related to LCV.
dc.description.indexMEDLINE
dc.identifier.citationIMMUNOLOGIC RESEARCH, v.65, n.1, Special Issue, p.395-401, 2017
dc.identifier.doi10.1007/s12026-016-8850-6
dc.identifier.eissn1559-0755
dc.identifier.issn0257-277X
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/20023
dc.language.isoeng
dc.publisherHUMANA PRESS INC
dc.relation.ispartofImmunologic Research
dc.rightsrestrictedAccess
dc.rights.holderCopyright HUMANA PRESS INC
dc.subjectCutaneous vasculitis
dc.subjectCutaneous leukocytoclastic vasculitis
dc.subjectCutaneous small vessel vasculitis
dc.subjectDirect immunofluorescence
dc.subject.otherhenoch-schonlein purpura
dc.subject.othersystemic-lupus-erythematosus
dc.subject.otherof-the-literature
dc.subject.othercutaneous-vasculitis
dc.subject.otherparaneoplastic-syndrome
dc.subject.otherclinical-significance
dc.subject.otherrheumatoid-arthritis
dc.subject.otherpregnancy
dc.subject.otherskin
dc.subject.othermalignancies
dc.subject.wosImmunology
dc.titleClinicopathologic correlation of 282 leukocytoclastic vasculitis cases in a tertiary hospital: a focus on direct immunofluorescence findings at the blood vessel wall
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalCARVALHO, Jozelio Freire de:Univ Fed Bahia, Hlth Sci Inst, Salvador, BA, Brazil
hcfmusp.citation.scopus12
hcfmusp.contributor.author-fmusphcCAROLINE MARIS TAKATU NEVES DE OLIVEIRA
hcfmusp.contributor.author-fmusphcANTONIO PEDRO RIBEIRO HERINGER
hcfmusp.contributor.author-fmusphcVALERIA AOKI
hcfmusp.contributor.author-fmusphcNEUSA YURIKO SAKAI VALENTE
hcfmusp.contributor.author-fmusphcPAULA CRISTINA DE FARIA SANCHEZ
hcfmusp.contributor.author-fmusphcPAULO RICARDO CRIADO
hcfmusp.description.beginpage395
hcfmusp.description.endpage401
hcfmusp.description.issue1
hcfmusp.description.issueSpecial Issue
hcfmusp.description.volume65
hcfmusp.origemWOS
hcfmusp.origem.pubmed27530606
hcfmusp.origem.scopus2-s2.0-84982094899
hcfmusp.origem.wosWOS:000400175600048
hcfmusp.publisher.cityTOTOWA
hcfmusp.publisher.countryUSA
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