BONE MARROW STEM CELLS IN FACIAL NERVE REGENERATION FROM ISOLATED STUMPS

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Arquivos
art_SALOMONE_BONE_MARROW_STEM_CELLS_IN_FACIAL_NERVE_REGENERATION_2013.PDF (255.66 KB)
Citações na Scopus
26
Tipo de produção
article
Data de publicação
2013
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
WILEY-BLACKWELL
Autores
AZZI-NOGUEIRA, Deborah
OVANDO, Patricia C.
DA-SILVA, Cira F.
HADDAD, Luciana A.
Citação
MUSCLE & NERVE, v.48, n.3, p.423-429, 2013
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
IntroductionSevere lesions in the facial nerve may have extensive axonal loss and leave isolated stumps that impose technical difficulties for nerve grafting. Methods: We evaluated bone marrow stem cells (BMSC) in a silicone conduit for rat facial nerve regeneration from isolated stumps. Group A utilized empty silicone tubes; in groups B-D, the tube was filled with acellular gel; and, in groups C and D, undifferentiated BMSC (uBMSC) or Schwann-like cells differentiated from BMSC (dBMSC) were added, respectively. Compound muscle action potentials (CMAPs) were measured, and histology was evaluated. Results: Groups C and D had the highest CMAP amplitudes. Group C had shorter CMAP durations than groups A, B, and D. Distal axonal number and density were increased in group C compared with groups A and B. Conclusions: Regeneration of the facial nerve was improved by both uBMSC and dBMSC in rats, yet uBMSC was associated with superior functional results.
Palavras-chave
electromyography, facial nerve, nerve conduction, nerve regeneration, stem cells
URI
https://observatorio.fm.usp.br/handle/OPI/4131
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MOF
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/24
Artigos e Materiais de Revistas Científicas - LIM/32