Polyenvironmental and polygenic risk scores and the emergence of psychotic experiences in adolescents

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorV, Gabrielle de Oliveira S. Navarro
dc.contributor.authorFONSECA, Lais
dc.contributor.authorTALARICO, Fernanda
dc.contributor.authorSPINDOLA, Leticia
dc.contributor.authorSANTORO, Marcos L.
dc.contributor.authorOTA, Vanessa K.
dc.contributor.authorCOGO-MOREIRA, Hugo
dc.contributor.authorMARI, Jair
dc.contributor.authorROHDE, Luis A.
dc.contributor.authorMIGUEL, Euripedes C.
dc.contributor.authorBRESSAN, Rodrigo A.
dc.contributor.authorPAN, Pedro M.
dc.contributor.authorGADELHA, Ary
dc.contributor.authorI, Sintia Belangero
dc.date.accessioned2021-10-20T14:02:01Z
dc.date.available2021-10-20T14:02:01Z
dc.date.issued2021
dc.description.abstractPsychotic experiences (PE) are forms of hallucinations and delusions neither reaching the intensity and functional impairment required to be regarded as full psychotic symptoms nor a psychotic disorder. Here we investigated the ability to predict PE using multiple models (regressions, mediation and moderation) using polygenic risk score for psychotic experiences (PE-PRS), polygenic risk score for schizophrenia (SCZ-PRS), and polyenvironmental risk score (PERS) in youth from a Brazilian sample. The scores were not able to predict outcome, either when both scores were combined (PERS + PE-PRS and PERS + SCZ-PRS) or separately. Our results show that there is no association between PE and PRS or PERS among adolescents in our Brazilian sample. The lack of association may be a result of the absence of better representativeness regarding genetic and environmental factors of our population.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipFundacao de Amparo a` Pesquisa do Estado de Sao Paulo (FAPESP)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientffico e Tecnologico (CNPq)Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ)
dc.identifier.citationJOURNAL OF PSYCHIATRIC RESEARCH, v.142, p.384-388, 2021
dc.identifier.doi10.1016/j.jpsychires.2021.07.057
dc.identifier.eissn1879-1379
dc.identifier.issn0022-3956
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/42348
dc.language.isoeng
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDeng
dc.relation.ispartofJournal of Psychiatric Research
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright PERGAMON-ELSEVIER SCIENCE LTDeng
dc.subjectPsychotic experienceseng
dc.subjectEnvironmentaleng
dc.subjectPolygenic risk scoreeng
dc.subjectPolyenvironmental risk scoreeng
dc.subjectPERSeng
dc.subjectPRSeng
dc.subject.othergeneral-populationeng
dc.subject.othersymptomseng
dc.subject.othermetaanalysiseng
dc.subject.otherchildhoodeng
dc.subject.othercontinuumeng
dc.subject.otherchildreneng
dc.subject.wosPsychiatryeng
dc.titlePolyenvironmental and polygenic risk scores and the emergence of psychotic experiences in adolescentseng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryNoruega
hcfmusp.affiliation.countryCanadá
hcfmusp.affiliation.countryisoca
hcfmusp.affiliation.countryisono
hcfmusp.author.externalV, Gabrielle de Oliveira S. Navarro:Univ Fed Sao Paulo, Dept Psychiat, Lab Integrat Neurosci LiNC, Sao Paulo, Brazil
hcfmusp.author.externalFONSECA, Lais:Univ Fed Sao Paulo, Dept Psychiat, Lab Integrat Neurosci LiNC, Sao Paulo, Brazil
hcfmusp.author.externalTALARICO, Fernanda:Univ Alberta, Dept Psychiat, Edmonton, AB, Canada
hcfmusp.author.externalSPINDOLA, Leticia:Univ Bergen, KG Jebsen Ctr Psychosis Res, Dept Clin Sci, NORMENT, Bergen, Norway; Haukeland Hosp, Ctr Med Genet & Mol Med, Dr Einar Martens Res Grp Biol Psychiat, Bergen, Norway
hcfmusp.author.externalSANTORO, Marcos L.:Univ Fed Sao Paulo, Dept Morphol & Genet, Genet Div, Sao Paulo, Brazil
hcfmusp.author.externalOTA, Vanessa K.:Univ Fed Sao Paulo, Dept Morphol & Genet, Genet Div, Sao Paulo, Brazil
hcfmusp.author.externalCOGO-MOREIRA, Hugo:Ostfold Univ Coll, Dept Educ ICT & Learning, Halden, Norway
hcfmusp.author.externalMARI, Jair:Univ Fed Sao Paulo, Dept Psychiat, Lab Integrat Neurosci LiNC, Sao Paulo, Brazil
hcfmusp.author.externalROHDE, Luis A.:Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, ADHD Program, Porto Alegre, RS, Brazil; Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Dev Psychiat Program, Porto Alegre, RS, Brazil
hcfmusp.author.externalBRESSAN, Rodrigo A.:Univ Fed Sao Paulo, Dept Psychiat, Lab Integrat Neurosci LiNC, Sao Paulo, Brazil
hcfmusp.author.externalPAN, Pedro M.:Univ Fed Sao Paulo, Dept Psychiat, Lab Integrat Neurosci LiNC, Sao Paulo, Brazil
hcfmusp.author.externalGADELHA, Ary:Univ Fed Sao Paulo, Dept Psychiat, Lab Integrat Neurosci LiNC, Sao Paulo, Brazil
hcfmusp.author.externalI, Sintia Belangero:Univ Fed Sao Paulo, Dept Psychiat, Lab Integrat Neurosci LiNC, Sao Paulo, Brazil; Univ Fed Sao Paulo, Dept Morphol & Genet, Genet Div, Sao Paulo, Brazil
hcfmusp.citation.scopus1
hcfmusp.contributor.author-fmusphcEURIPEDES CONSTANTINO MIGUEL FILHO
hcfmusp.description.beginpage384
hcfmusp.description.endpage388
hcfmusp.description.volume142
hcfmusp.origemWOS
hcfmusp.origem.pubmed34450553
hcfmusp.origem.scopus2-s2.0-85113371351
hcfmusp.origem.wosWOS:000693457700018
hcfmusp.publisher.cityOXFORDeng
hcfmusp.publisher.countryENGLANDeng
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