Anti-Zika virus activity of several abietane-type ferruginol analogues

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSOUSA, Francielle T. G.
dc.contributor.authorNUNES, Cristina
dc.contributor.authorROMANO, Camila Malta
dc.contributor.authorSABINO, Ester Cerdeira
dc.contributor.authorGONZALEZ-CARDENETE, Miguel Angel
dc.date.accessioned2021-02-18T13:30:28Z
dc.date.available2021-02-18T13:30:28Z
dc.date.issued2020
dc.description.abstractAbietane diterpenoids are naturally occurring plant metabolites with a broad spectrum of biological effects including antibacterial. antileishmanial, antitumor, antioxidant, as well as antiinfiammatory activities. Recently, we found that some analogues of natural ferruginol (2) actively inhibited dengue virus 2 (DENV-2) replication. Due to the similarity with DENY, we envisaged that abietane diteipenoids would also be active against Zika virus (ZIKV). Six selected semi-synthetic abietane derivatives of (+)-dehydroabietylatnine (3) were tested. Cytotoxicity was determined by Mn' assay in Vero cells. In vitro anti-ZIKV (clinical isolate. imT17) activity was evaluated by plaque assay. Interestingly, these molecules showed potential as anti-ZIKV agents, with EC50 values ranging from 0.67 to 18.57 mu M. and cytotoxicity (CC50 values) from 256 to 35.09 mu M. The 18-Oxoferruginol (8) (EC50 = 2.60 mu M, SI = 13.51) and 12-nitro-N-benzoyldehydroabietylamine (9) (ECG 0.67 mu M, SI = 3.82) were the most active compounds, followed by 12-hydroxy-N-tosyldehydroabietylamine (7) (EC50 = 3.58 mu M, SI = 3.20) and 12-hydroxy-N,N-phthaloyldehydroabietylamine (5) (EC50 = 7.76 mu M, SI = 1.23). To the best of our knowledge, this is the first report on anti-Zika virus properties of abietanes.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipUniversitat Politecnica de Valencia, under a cooperation ""ADSIDEO"" research grant [AD1902]
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2013/01690-0, 2019/03859-9]
dc.description.sponsorshipFAPESP ScholarshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2013/017029]
dc.identifier.citationREVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO, v.62, article ID e97, 4p, 2020
dc.identifier.doi10.1590/S1678-9946202062097
dc.identifier.eissn1678-9946
dc.identifier.issn0036-4665
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/39229
dc.language.isoeng
dc.publisherINST MEDICINA TROPICAL SAO PAULOeng
dc.relation.ispartofRevista do Instituto de Medicina Tropical de Sao Paulo
dc.rightsopenAccesseng
dc.rights.holderCopyright INST MEDICINA TROPICAL SAO PAULOeng
dc.subjectZikaeng
dc.subjectAbietaneeng
dc.subjectDitelpenoideng
dc.subjectSemi-synthesiseng
dc.subjectAnti-ZIKV activityeng
dc.subject.wosInfectious Diseaseseng
dc.subject.wosParasitologyeng
dc.subject.wosTropical Medicineeng
dc.titleAnti-Zika virus activity of several abietane-type ferruginol analogueseng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryEspanha
hcfmusp.affiliation.countryisoes
hcfmusp.author.externalGONZALEZ-CARDENETE, Miguel Angel:Univ Politecn Valencia, Inst Tecnol Quim, CSIC, Avda Naranjos S-N, Valencia 46022, Spain
hcfmusp.citation.scopus12
hcfmusp.contributor.author-fmusphcFRANCIELLE TRAMONTINI GOMES DE SOUSA
hcfmusp.contributor.author-fmusphcCRISTINA FREITAS NUNES
hcfmusp.contributor.author-fmusphcCAMILA MALTA ROMANO
hcfmusp.contributor.author-fmusphcESTER CERDEIRA SABINO
hcfmusp.description.articlenumbere97
hcfmusp.description.volume62
hcfmusp.origemWOS
hcfmusp.origem.pubmed33295481
hcfmusp.origem.scieloSCIELO:S0036-46652020000100614
hcfmusp.origem.scopus2-s2.0-85097516506
hcfmusp.origem.wosWOS:000599300600002
hcfmusp.publisher.citySAO PAULOeng
hcfmusp.publisher.countryBRAZILeng
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hcfmusp.scopus.lastupdate2024-06-14
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