Molecular Epidemiology of Rubella Viruses Involved in Congenital Rubella Infections in Sao Paulo, Brazil, Between 1996 and 2009
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Citações na Scopus
6
Tipo de produção
article
Data de publicação
2013
Título da Revista
ISSN da Revista
Título do Volume
Editora
WILEY-BLACKWELL
Autores
CURTI, Suely Pires
FIGUEIREDO, Cristina Adelaide
OLIVEIRA, Maria Isabel de
YU, Ana Lucia Frugis
OLIVEIRA, Danielle Bruna
DURIGON, Edison Luiz
Citação
JOURNAL OF MEDICAL VIROLOGY, v.85, n.11, p.2034-2041, 2013
Resumo
Rubella virus (RV) infection during the early stages of pregnancy can lead to serious birth defects, known as congenital rubella syndrome (CRS). This retrospective study was conducted between 1996 and 2009 with surveillance specimens collected from patients suspected of congenital rubella infection (CRI) and CRS. The clinical samples (nine amminiotic fluid, eight urine, eight blood, one conception product, and one placenta) were sent for viral isolation and genotyping. Twenty-seven sequences were analysed and four genotypes (1a, 1B, 1G, and 2B) were identified in SAo Paulo that were involved in congenital infection. To our knowledge, this study is the first report that describes genetic diversity of the circulating rubella strains involved in CRI. J Med. Virol. 85:2034-2041, 2013. (c) 2013 Wiley Periodicals, Inc.
Palavras-chave
congenital rubella infection, congenital rubella syndrome, isolation, RT-PCR, genotype
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