StreptInCor: A Candidate Vaccine Epitope against S. pyogenes Infections Induces Protection in Outbred Mice

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorPOSTOL, Edilberto
dc.contributor.authorALENCAR, Raquel
dc.contributor.authorHIGA, Fabio T.
dc.contributor.authorBARROS, Samar Freschi de
dc.contributor.authorDEMARCHI, Lea M. F.
dc.contributor.authorKALIL, Jorge
dc.contributor.authorGUILHERME, Luiza
dc.date.accessioned2013-09-23T16:36:01Z
dc.date.available2013-09-23T16:36:01Z
dc.date.issued2013
dc.description.abstractInfection with Streptococcus pyogenes (S. pyogenes) can result in several diseases, particularly in children. S. pyogenes M protein is the major virulence factor, and certain regions of its N-terminus can trigger autoimmune sequelae such as rheumatic fever in susceptible individuals with untreated group A streptococcal pharyngitis. In a previous study, we utilized a large panel of human peripheral blood cells to define the C-terminal protective epitope StreptInCor (medical identity), which does not induce autoimmune reactions. We recently confirmed the results in HLA-transgenic mice. In the present study, we extended the experimental assays to outbred animals (Swiss mice). Herein, we demonstrate high titers of StreptInCor-specific antibodies, as well as appropriate T-cell immune responses. No cross-reaction to cardiac myosin was detected. Additionally, immunized Swiss mice exhibited 87% survival one month after challenge with S. pyogenes. In conclusion, the data presented herein reinforce previous results in humans and animals and further emphasize that StreptInCor could be an effective and safe vaccine for the prevention of S. pyogenes infections.
dc.description.indexMEDLINE
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.description.sponsorshipFinanciadora de Estudos e Projetos (FINEP)
dc.identifier.citationPLOS ONE, v.8, n.4, article ID e60969, 6p, 2013
dc.identifier.doi10.1371/journal.pone.0060969
dc.identifier.issn1932-6203
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/1729
dc.language.isoeng
dc.publisherPUBLIC LIBRARY SCIENCE
dc.relation.ispartofPlos One
dc.rightsopenAccess
dc.rights.holderCopyright PUBLIC LIBRARY SCIENCE
dc.subject.othergroup-a streptococcus
dc.subject.otherrheumatic heart-disease
dc.subject.otherm-protein
dc.subject.othercardiac myosin
dc.subject.otherpharyngitis
dc.subject.otherintranasal
dc.subject.otherburden
dc.subject.otherfever
dc.subject.otherimmunogenicity
dc.subject.otherepidemiology
dc.subject.wosMultidisciplinary Sciences
dc.titleStreptInCor: A Candidate Vaccine Epitope against S. pyogenes Infections Induces Protection in Outbred Mice
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalHIGA, Fabio T.:Univ Sao Paulo, Sch Med, Inst Heart, Sao Paulo, Brazil; Univ Sao Paulo, Natl Inst Sci & Technol, Inst Immunol Invest, Sao Paulo, Brazil
hcfmusp.citation.scopus37
hcfmusp.contributor.author-fmusphcEDILBERTO POSTOL
hcfmusp.contributor.author-fmusphcRAQUEL ELAINE DE ALENCAR
hcfmusp.contributor.author-fmusphcSAMAR FRESCHI DE BARROS
hcfmusp.contributor.author-fmusphcLEA MARIA MACRUZ FERREIRA DEMARCHI
hcfmusp.contributor.author-fmusphcJORGE ELIAS KALIL FILHO
hcfmusp.contributor.author-fmusphcLUIZA GUILHERME GUGLIELMI
hcfmusp.description.articlenumbere60969
hcfmusp.description.issue4
hcfmusp.description.volume8
hcfmusp.origemWOS
hcfmusp.origem.pubmed23593359
hcfmusp.origem.scopus2-s2.0-84876009986
hcfmusp.origem.wosWOS:000317898000087
hcfmusp.publisher.citySAN FRANCISCO
hcfmusp.publisher.countryUSA
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hcfmusp.remissive.sponsorshipCNPq
hcfmusp.remissive.sponsorshipFAPESP
hcfmusp.remissive.sponsorshipFederico Foundation
hcfmusp.remissive.sponsorshipFINEP
hcfmusp.scopus.lastupdate2024-05-17
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