Association between torquetenovirus in vaginal secretions and infertility: An exploratory metagenomic analysis

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorCOSTA, A. Charlys Da
dc.contributor.authorBORTOLETTO, Pietro
dc.contributor.authorSPANDORFER, Steven D.
dc.contributor.authorTOZETTO-MENDOZA, Tania Regina
dc.contributor.authorLINHARES, Iara M.
dc.contributor.authorMENDES-CORREA, Maria Cassia
dc.contributor.authorWITKIN, Steven S.
dc.date.accessioned2023-12-15T18:52:38Z
dc.date.available2023-12-15T18:52:38Z
dc.date.issued2023
dc.description.abstractProblemThe association of viruses with infertility remains incompletely evaluated.Method of studyVaginal secretions from 46 women seeking treatment in the Center for Reproductive Medicine and Infertility at Weill Cornell Medicine were tested for viruses by metagenomic analysis by lab personnel blinded to all clinical data.ResultsTorquetenovirus (TTV) was identified in 16 women, alphapapillomavirus in seven women and most were positive for bacteriophages. Twelve of the subjects were fertile and sought to freeze their oocytes for future implantation. These women were all negative for TTV. In contrast, 16 of the 34 women (47.1%) being treated for infertility were TTV-positive (p = .0035). Evaluating the women by cause of infertility, five of nine women (55.6%) whose male partner had inadequate sperm parameters and six of 14 women (42.9%) with defective ovulation were TTV positive (p = .0062 and p = .0171, respectively, vs. the fertile women). Alphapapillomavirus was identified in one (8.3%) fertile woman, five (35.7%) women with ovulation deficiency, and one (11.1%) woman with male factor infertility. These differences were not statistically significant. There were no differences in bacteriophage families or the presence of Lactobacillus phages between fertile or infertile women or between different causes of infertility. There was a negative association between TTV detection and Lactobacillus crispatus dominance in the vaginal microbiota (p = .0184), but no association between TTV detection and the presence of alphapapillomavirus or Candida species.ConclusionDetection of TTV in the vagina might be a biomarker for specific causes of infertility.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus
dc.identifier.citationAMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, v.90, n.5, article ID e13788, 6p, 2023
dc.identifier.doi10.1111/aji.13788
dc.identifier.eissn1600-0897
dc.identifier.issn1046-7408
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/57434
dc.language.isoeng
dc.publisherWILEYeng
dc.relation.ispartofAmerican Journal of Reproductive Immunology
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright WILEYeng
dc.subjectalphapapillomaviruseng
dc.subjectinfertilityeng
dc.subjectmetagenomic analysiseng
dc.subjecttorquetenoviruseng
dc.subjectvaginal secretionseng
dc.subject.otherviral-infectioneng
dc.subject.otherbacterialeng
dc.subject.otherwomeneng
dc.subject.otherprevalenceeng
dc.subject.otherdnaeng
dc.subject.wosImmunologyeng
dc.subject.wosReproductive Biologyeng
dc.titleAssociation between torquetenovirus in vaginal secretions and infertility: An exploratory metagenomic analysiseng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryisous
hcfmusp.author.externalBORTOLETTO, Pietro:Boston IVF, Waltham, MA USA; Harvard Med Sch, Boston, MA USA; Beth Israel Deaconess Med Ctr, Dept Obstet & Gynecol, Boston, MA USA
hcfmusp.author.externalSPANDORFER, Steven D.:Weill Cornell Med, Ctr Reprod Med & Infertil, New York, NY USA
hcfmusp.citation.scopus0
hcfmusp.contributor.author-fmusphcANTONIO CHARLYS DA COSTA
hcfmusp.contributor.author-fmusphcTANIA REGINA TOZETTO MENDOZA
hcfmusp.contributor.author-fmusphcIARA MORENO LINHARES
hcfmusp.contributor.author-fmusphcMARIA CASSIA JACINTHO MENDES CORREA
hcfmusp.contributor.author-fmusphcSTEVEN SOL WITKIN
hcfmusp.description.articlenumbere13788
hcfmusp.description.issue5
hcfmusp.description.volume90
hcfmusp.origemWOS
hcfmusp.origem.pubmed37881119
hcfmusp.origem.scopus2-s2.0-85174852357
hcfmusp.origem.wosWOS:001087241100001
hcfmusp.publisher.cityHOBOKENeng
hcfmusp.publisher.countryUSAeng
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