Etonogestrel-releasing contraceptive implant in a patient using thalidomide for the treatment of erythema nodosum leprosum: a case report
Carregando...
Citações na Scopus
1
Tipo de produção
article
Data de publicação
2022
Título da Revista
ISSN da Revista
Título do Volume
Editora
TAYLOR & FRANCIS LTD
Citação
GYNECOLOGICAL ENDOCRINOLOGY, v.38, n.1, p.90-93, 2022
Resumo
Introduction Thalidomide is an immunomodulatory drug and first choice in the treatment of erythema nodosum leprosum. Given its teratogenic potential, it is essential that an effective contraceptive method is used, especially a long-acting reversible contraceptive (LARC) method. The subdermal etonogestrel (ENG)-releasing implant is an adequate method due to the high effectiveness and long-term use. However, interaction between thalidomide and ENG has not been well documented. Concern arises because thalidomide interacts with cytochrome P450 (CYP450) enzymes that metabolize sexual steroids. AIM: We aimed to study the effectiveness and safety of the ENG-implant in a thalidomide user. Methods Case report of a sexually active 21-year-old patient with both Hansen's disease and leprosy reaction type 2 treated with thalidomide requiring effective contraception. Follow-up was up to 36 months after implant placement. Results Contraception with ENG-implant was effective and safe, based on clinical parameters (reduction of menstrual flow and cervical mucus thickening) and laboratory parameters (gonadotropins and sexual steroids). Conclusion To the best of our knowledge, this is the first case reported which presents a patient in simultaneous use of thalidomide and ENG-implant. Although this case report preliminary supports effectiveness and safety of ENG-implant as a contraceptive option in women using thalidomide, rigorous drug-drug interaction research is needed to better characterize the interaction between thalidomide and the ENG-implant.
Palavras-chave
Thalidomide, leprosy, etonogestrel, subdermal implant, contraceptive agents, case report
Referências
- Ag?ncia Nacional de, 2011, RESOLU O RDC NO 11
- Ali M, 2017, GLOB HEALTH-SCI PRAC, V5, P534, DOI 10.9745/GHSP-D-17-00296
- Bennink H J, 2000, Eur J Contracept Reprod Health Care, V5 Suppl 2, P12
- Croxatto HB, 2002, CONTRACEPTION, V65, P21, DOI 10.1016/S0010-7824(01)00294-3
- DAVIES GC, 1993, CONTRACEPTION, V47, P251, DOI 10.1016/0010-7824(93)90042-6
- Drummond PLD, 2019, REV SOC BRAS MED TRO, V52, DOI 10.1590/0037-8682-0385-2018
- Di Carlo C, 2015, GYNECOL ENDOCRINOL, V31, P491, DOI 10.3109/09513590.2015.1018163
- DIAZ S, 1991, CONTRACEPTION, V44, P393, DOI 10.1016/0010-7824(91)90030-J
- Eichelmann K, 2013, ACTAS DERMO-SIFILOGR, V104, P554, DOI [10.1016/j.ad.2012.03.003, 10.1016/j.adengl.2012.03.028]
- Ferreira JM, 2014, CONTRACEPTION, V89, P17, DOI 10.1016/j.contraception.2013.09.012
- Ferreira ES, 2020, EXPERT REV CLIN PHAR, V13, P615, DOI 10.1080/17512433.2020.1782738
- Graesslin O, 2008, EUR J CONTRACEP REPR, V13, P4, DOI 10.1080/13625180801942754
- Harrison-Woolrych M, 2005, CONTRACEPTION, V71, P306, DOI 10.1016/j.contraception.2004.10.005
- Lange Jill, 2014, J Med Case Rep, V8, P43, DOI 10.1186/1752-1947-8-43
- Madden T, 2015, AM J OBSTET GYNECOL, V213, DOI 10.1016/j.ajog.2015.01.051
- Murayama N, 2017, J TOXICOL SCI, V42, P343, DOI 10.2131/jts.42.343
- Murayama N, 2014, CHEM RES TOXICOL, V27, P304, DOI 10.1021/tx4004374
- OLSSON SE, 1990, CONTRACEPTION, V42, P1, DOI 10.1016/0010-7824(90)90087-C
- Robbins G, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005669
- Scheffler MR, 1999, CLIN PHARMACOL THER, V65, P483, DOI 10.1016/S0009-9236(99)70067-6
- Sunaga T, 2021, CONTRACEPTION, V103, P222, DOI 10.1016/j.contraception.2020.12.002
- Trapnell CB, 1998, CLIN PHARMACOL THER, V64, P597, DOI 10.1016/S0009-9236(98)90050-9
- TRUSSELL J, 1995, ARCH DERMATOL, V131, P1064, DOI 10.1001/archderm.131.9.1064
- Upputuri B, 2020, PLOS NEGLECT TROP D, V14, DOI 10.1371/journal.pntd.0008678
- Vargesson N, 2015, BIRTH DEFECTS RES C, V105, P140, DOI 10.1002/bdrc.21096
- World Health Organization, 2012, World Health Organ Tech Rep Ser, P1