The Role of MIR9-2 in Shared Susceptibility of Psychiatric Disorders during Childhood: A Population-Based Birth Cohort Study

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorTOVO-RODRIGUES, Luciana
dc.contributor.authorQUINTE, Gabriela Callo
dc.contributor.authorBRUM, Clarice Brinck
dc.contributor.authorGHISLENI, Gabriele
dc.contributor.authorBASTOS, Clarissa Ribeiro
dc.contributor.authorOLIVEIRA, Isabel Oliveira de
dc.contributor.authorBARROS, Fernando C.
dc.contributor.authorBARROS, Aluisio J. D.
dc.contributor.authorSANTOS, Ina S.
dc.contributor.authorROHDE, Luis A.
dc.contributor.authorHUTZ, Mara H.
dc.contributor.authorMATIJASEVICH, Alicia
dc.date.accessioned2019-11-06T18:49:44Z
dc.date.available2019-11-06T18:49:44Z
dc.date.issued2019
dc.description.abstractBackground: It has been suggested that microRNAs (miRNAs; short non-protein-coding RNA molecules that mediate post-transcriptional regulation), including mir-9 and mir-34 families, are important for brain development. Current data suggest that mir-9 and mir-34 may have shared effects across psychiatric disorders. This study aims to explore the role of genetic polymorphisms in the MIR9-2 (rs4916723) and MIR34B/C (rs4938723) genes on the susceptibility of psychiatric disorders in children from the 2004 Pelotas Birth Cohort. Methods: Psychiatric disorders were assessed in 3585 individuals using Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV), criteria through the application of standard semi-structured interviews (using the Development and Well-Being Assessment, DAWBA) at the six-years-of-age follow-up. The outcome was defined as the presence of any mental disorder. We also considered two broad groups of internalizing and externalizing disorders to further investigate the role of these variants in mental health. Results: We observed an association between rs4916723 (MIR9-2) and the presence of any psychiatric disorder (odds ratios (OR) = 0.820; 95% CI = 0.7130-0.944; p = 0.006) and a suggestive effect on internalizing disorders (OR = 0.830; 95% CI = 0.698-0.987; p = 0.035). rs4938723 (MIR34B/C) was not associated with any evaluated outcome. Conclusion: The study suggests that MIR9-2 may have an important role on a broad susceptibility for psychiatric disorders and may be important mainly for internalization problems.eng
dc.description.indexPubMedeng
dc.description.sponsorshipWellcome TrustWellcome Trust
dc.description.sponsorshipWorld Health Organization, National Support Program for Centers of Excellence (PRONEX)
dc.description.sponsorshipBrazilian National Research Council (CNPq)National Council for Scientific and Technological Development (CNPq)
dc.description.sponsorshipBrazilian Ministry of Health
dc.description.sponsorshipPelotas Birth Cohort
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior-BrasilCAPES [001]
dc.description.sponsorshipResearch Support Foundation of Rio Grande do Sul-FAPERGS (Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul) [16/2551-0000374-2-Fapergs/CNPq 08/2014]
dc.description.sponsorshipCNPqNational Council for Scientific and Technological Development (CNPq)
dc.identifier.citationGENES, v.10, n.8, article ID 626, 11p, 2019
dc.identifier.doi10.3390/genes10080626
dc.identifier.eissn2073-4425
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/34084
dc.language.isoeng
dc.publisherMDPIeng
dc.relation.ispartofGenes
dc.rightsopenAccesseng
dc.rights.holderCopyright MDPIeng
dc.subjectmental healtheng
dc.subjectgeneticseng
dc.subjectmicroRNAeng
dc.subjectbirth cohorteng
dc.subject.otherage-of-onseteng
dc.subject.othermajor depressioneng
dc.subject.othermental-disorderseng
dc.subject.othermicrornaseng
dc.subject.othercelleng
dc.subject.otherexpressioneng
dc.subject.otherpolymorphismseng
dc.subject.otherneuroticismeng
dc.subject.otherprevalenceeng
dc.subject.otherprofileeng
dc.subject.wosGenetics & Heredityeng
dc.titleThe Role of MIR9-2 in Shared Susceptibility of Psychiatric Disorders during Childhood: A Population-Based Birth Cohort Studyeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalTOVO-RODRIGUES, Luciana:Univ Catolica Pelotas, Postgrad Program Hlth & Behav, BR-96015560 Pelotas, RS, Brazil
hcfmusp.author.externalQUINTE, Gabriela Callo:Univ Catolica Pelotas, Postgrad Program Hlth & Behav, BR-96015560 Pelotas, RS, Brazil
hcfmusp.author.externalBRUM, Clarice Brinck:Univ Catolica Pelotas, Postgrad Program Hlth & Behav, BR-96015560 Pelotas, RS, Brazil
hcfmusp.author.externalGHISLENI, Gabriele:Univ Catolica Pelotas, Postgrad Program Hlth & Behav, Lab Clin Neurosci, BR-96015560 Pelotas, RS, Brazil
hcfmusp.author.externalBASTOS, Clarissa Ribeiro:Univ Catolica Pelotas, Postgrad Program Hlth & Behav, Lab Clin Neurosci, BR-96015560 Pelotas, RS, Brazil
hcfmusp.author.externalOLIVEIRA, Isabel Oliveira de:Univ Catolica Pelotas, Postgrad Program Hlth & Behav, BR-96015560 Pelotas, RS, Brazil
hcfmusp.author.externalBARROS, Fernando C.:Univ Catolica Pelotas, Postgrad Program Hlth & Behav, BR-96015560 Pelotas, RS, Brazil
hcfmusp.author.externalBARROS, Aluisio J. D.:Univ Catolica Pelotas, Postgrad Program Hlth & Behav, BR-96015560 Pelotas, RS, Brazil
hcfmusp.author.externalSANTOS, Ina S.:Univ Catolica Pelotas, Postgrad Program Hlth & Behav, BR-96015560 Pelotas, RS, Brazil; Pontificia Univ Catolica Rio Grande do Sul, Postgrad Program Pediat Child Hlth, BR-90619900 Porto Alegre, RS, Brazil
hcfmusp.author.externalROHDE, Luis A.:Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Dept Psychiat, BR-90035007 Porto Alegre, RS, Brazil; Natl Inst Dev Psychiat Children & Adolescents, BR-05403900 Sao Paulo, SP, Brazil
hcfmusp.author.externalHUTZ, Mara H.:Univ Fed Rio Grande Do Sul, Program Genet & Mol Biol, BR-91501970 Porto Alegre, RS, Brazil
hcfmusp.citation.scopus6
hcfmusp.contributor.author-fmusphcALICIA MATIJASEVICH MANITTO
hcfmusp.description.articlenumber626
hcfmusp.description.issue8
hcfmusp.description.volume10
hcfmusp.origemWOS
hcfmusp.origem.pubmed31434288
hcfmusp.origem.scopus2-s2.0-85077739673
hcfmusp.origem.wosWOS:000483744500021
hcfmusp.publisher.cityBASELeng
hcfmusp.publisher.countrySWITZERLANDeng
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