Biomechanical Properties and Microstructural Analysis of the Human Nonaneurysmal Aorta as a Function of Age, Gender and Location: An Autopsy Study
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Citações na Scopus
21
Tipo de produção
article
Data de publicação
2015
Título da Revista
ISSN da Revista
Título do Volume
Editora
KARGER
Autores
Citação
JOURNAL OF VASCULAR RESEARCH, v.52, n.4, p.257-264, 2015
Resumo
Introduction: The biomechanical failure properties and histological composition of the human nonaneurysmal aorta were studied. Methods: Twenty-six human aortas were harvested from fresh cadavers at autopsy. A total of 153 circumferentially oriented strips were obtained from the aortas for biomechanical and histological studies. Results: The failure load (6.18 +/- 2.03 vs. 4.85 +/- 2.04 N; p = 0.001), failure tension (19.88 +/- 9.05 vs. 14.53 +/- 7 N/cm; p = 0.001), failure strain (0.66 +/- 0.31 vs. 0.49 +/- 0.25; p = 0.003) and amount of elastic fibers (19.39 +/- 15.57 vs. 14.06 +/- 9.5%; p = 0.011) were all significantly higher for the thoracic than the abdominal aorta. There was a significant negative correlation between age and failure load (R = -0.35; p < 0.0001), failure stress (R = -0.63; p < 0.0001), failure tension (R = -0.52; p < 0.0001) and failure strain (R = -0.8; p < 0.0001). Male aortas had a higher failure load and failure tension than female aortas. Conclusion: The thoracic aorta has a higher strength and elasticity than the abdominal aorta. The elderly have weaker and stiffer aortas than the young. Male aortas are stronger than female aortas. (C) 2016 S. Karger AG, Basel
Palavras-chave
Biomechanics, Elasticity, Histology, Human aorta, Mechanical stress
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