Oral Squamous Cell Carcinoma Bone Invasion: Possible Roles of E-Cadherin in Osteoclastogenesis and Bone Infiltration

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorKOYAMA, Leonardo Kenji Sakaue
dc.contributor.authorNAGANO, Cibele Pidorodeski
dc.contributor.authorVANINI, Jaqueline Vaz
dc.contributor.authorJR, Jose Martins Figueredo
dc.contributor.authorMATOS, Leandro Luongo de
dc.contributor.authorCERNEA, Claudio Roberto
dc.contributor.authorCOUTINHO-CAMILLO, Claudia Malheiros
dc.contributor.authorLOURENCO, Silvia Vanessa
dc.date.accessioned2021-10-20T13:54:07Z
dc.date.available2021-10-20T13:54:07Z
dc.date.issued2021
dc.description.abstractIntroduction: Squamous cell carcinoma is the most common cancer of the oral cavity. When the tumor invades the bone tissue, the prognostic and survival rates decrease a lot, and the treatment becomes more aggressive, with several damages to the patient and health system. Many of the molecular mechanisms of bone invasion process are not understood yet, but it is already known that one of central processes of tumor evolution - adjacent tissues invasion and metastasis - is a large spectrum of phenotypic changes in epithelial cells to mesenchymal, in a process named as epithelial-mesenchymal transition (EMT). Loss of E-cadherin, an important epithelial cell adhesion protein, is a hallmark of this phenomenon. The objective of this retrospective study is to evaluate the expression of E-cadherin protein, comparing its distribution with clinical characteristics of the patients and possibly relation to EMT. Methods: Sixty-two cases with respective clinical data were analyzed by comparing immunohistochemical, H and E staining, and clinical data, observing the tumor-bone interface (TBI) and the surrounding tumor that had no direct contact with the bone surface (ST). Results: Forty cases were positive for E-cadherin (64%) with a heterogeneous pattern. Statistical analysis showed a significant difference between the presence of E-cadherin expression and tobacco smokers. Also, the equal or weaker protein expression in the ST than TBI is related to a worse overall survival. No statistically significant difference in other prognostic factors was observed. Conclusion: Our results suggest that the tumor cells that interact with the bone tissue could gain molecular changes, like partial EMT and osteoclastogenesis induction, which facilitate their migration and increase the bone resorption, resulting in a worse patient's prognosis.eng
dc.description.indexMEDLINEeng
dc.identifier.citationORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY HEAD AND NECK SURGERY, v.83, n.5, p.354-361, 2021
dc.identifier.doi10.1159/000514229
dc.identifier.eissn1423-0275
dc.identifier.issn0301-1569
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/42008
dc.language.isoeng
dc.publisherKARGEReng
dc.relation.ispartofOrl-Journal for Oto-rhino-laryngology Head and Neck Surgery
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright KARGEReng
dc.subjectSquamous cell carcinomaeng
dc.subjectNeoplasm invasioneng
dc.subjectE-cadherineng
dc.subject.othermandibular invasioneng
dc.subject.otherexpressioneng
dc.subject.othercancereng
dc.subject.wosOtorhinolaryngologyeng
dc.titleOral Squamous Cell Carcinoma Bone Invasion: Possible Roles of E-Cadherin in Osteoclastogenesis and Bone Infiltrationeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalNAGANO, Cibele Pidorodeski:Univ Sao Paulo, Dent Sch, Dept Gen Pathol, Sao Paulo, Brazil
hcfmusp.author.externalVANINI, Jaqueline Vaz:Univ Sao Paulo, Dent Sch, Dept Gen Pathol, Sao Paulo, Brazil
hcfmusp.author.externalJR, Jose Martins Figueredo:Univ Sao Paulo, Dent Sch, Dept Gen Pathol, Sao Paulo, Brazil
hcfmusp.author.externalCOUTINHO-CAMILLO, Claudia Malheiros:AC Camargo Canc Ctr, Int Res Ctr, Sao Paulo, Brazil
hcfmusp.author.externalLOURENCO, Silvia Vanessa:Univ Sao Paulo, Dent Sch, Dept Gen Pathol, Sao Paulo, Brazil
hcfmusp.citation.scopus2
hcfmusp.contributor.author-fmusphcLEONARDO KENJI SAKAUE KOYAMA
hcfmusp.contributor.author-fmusphcLEANDRO LUONGO DE MATOS
hcfmusp.contributor.author-fmusphcCLAUDIO ROBERTO CERNEA
hcfmusp.description.beginpage354
hcfmusp.description.endpage361
hcfmusp.description.issue5
hcfmusp.description.volume83
hcfmusp.origemWOS
hcfmusp.origem.pubmed34034265
hcfmusp.origem.scopus2-s2.0-85107652994
hcfmusp.origem.wosWOS:000655129000001
hcfmusp.publisher.cityBASELeng
hcfmusp.publisher.countrySWITZERLANDeng
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