Into the Island: A new technique of non-invasive cortical stimulation of the insula
Carregando...
Citações na Scopus
46
Tipo de produção
article
Data de publicação
2012
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Autores
Citação
NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY, v.42, n.6, p.363-368, 2012
Resumo
Study aim. - We describe a new neuronavigation-guided technique to target the posterior-superior insula (PSI) using a cooled-double-cone coil for deep cortical stimulation. Introduction. - Despite the analgesic effects brought about by repetitive transcranial magnetic stimulation (TMS) to the primary motor and prefrontal cortices, a significant proportion of patients remain symptomatic. This encouraged the search for new targets that may provide stronger pain relief. There is growing evidence that the posterior insula is implicated in the integration of painful stimuli in different pain syndromes and in homeostatic thermal integration. Methods. - The primary motor cortex representation of the lower leg was used to calculate the motor threshold and thus, estimate the intensity of PSI stimulation. Results. - Seven healthy volunteers were stimulated at 10 Hz to the right PSI and showed subjective changes in cold perception. The technique was safe and well tolerated. Conclusions. - The right posterior-superior insula is worth being considered in future studies as a possible target for rTMS stimulation in chronic pain patients.
Palavras-chave
Insula, Neuronavigation, Analgesia
Referências
- Blomqvist A, 2000, BRAIN, V123, P601, DOI 10.1093/brain/123.3.601
- BURTON H, 1993, SOMATOSENS MOT RES, V10, P297, DOI 10.3109/08990229309028839
- Burton H, 1986, CEREB CORTEX, P31
- Craig ADB, 2003, TRENDS NEUROSCI, V26, P303, DOI 10.1016/S0166-2236(03)00123-1
- de Andrade DC, 2011, PAIN, V152, P320, DOI 10.1016/j.pain.2010.10.032
- Desmeules JA, 2003, ARTHRITIS RHEUM, V48, P1420, DOI 10.1002/art.10893
- Ducreux D, 2006, BRAIN, V129, P963, DOI 10.1093/brain/awl016
- Gagne M, 2010, HUM BRAIN MAPP, V32, P509
- Hansson PT, 2009, EUR J PAIN, V13, P439, DOI 10.1016/j.ejpain.2009.02.008
- Lefaucheur JP, 2008, BRAIN STIMUL, V1, P337, DOI 10.1016/j.brs.2008.07.003
- Lefaucheur JP, 2001, NEUROREPORT, V12, P2963, DOI 10.1097/00001756-200109170-00041
- Mazzola L, 2012, BRAIN, V135, P631, DOI 10.1093/brain/awr265
- MESULAM MM, 1982, J COMP NEUROL, V212, P38, DOI 10.1002/cne.902120104
- Mhalla A, 2011, PAIN, V152, P1478, DOI 10.1016/j.pain.2011.01.034
- Mhalla A, 2010, PAIN, V149, P495, DOI 10.1016/j.pain.2010.03.009
- Penfield W, 1954, EPILEPSY FUNCTIONAL
- Peyron R, 2000, NEUROPHYSIOL CLIN, V30, P263, DOI 10.1016/S0987-7053(00)00227-6
- Sidhu SK, 2012, J NEUROPHYSIOL, V107, P306, DOI 10.1152/jn.00212.2011
- TARKKA IM, 1993, J CLIN NEUROPHYSIOL, V10, P513, DOI 10.1097/00004691-199310000-00009
- Taylor JL, 2004, J APPL PHYSIOL, V96, P1496, DOI 10.1152/japplphysiol.01116.2003
- Terao Y, 2002, J CLIN NEUROPHYSIOL, V19, P322, DOI 10.1097/00004691-200208000-00006