MANOEL JACOBSEN TEIXEIRA
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Neurologia, Faculdade de Medicina - Docente
LIM/62 - Laboratório de Fisiopatologia Cirúrgica, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/62 - Laboratório de Fisiopatologia Cirúrgica, Hospital das Clínicas, Faculdade de Medicina - Líder
833 resultados
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- Routine postoperative computed tomography scan after craniotomy: systematic review and evidence-based recommendations(2021) BLUMRICH, Lukas; TELLES, Joao Paulo Mota; SILVA, Saul Almeida da; IGLESIO, Ricardo Ferrareto; TEIXEIRA, Manoel Jacobsen; FIGUEIREDO, Eberval GadelhaOver the last few years, the role of early postoperative computed tomography (EPOCT) after cranial surgery has been repeatedly questioned, but there is yet no consensus on the practice. We conducted a systematic review to address the usefulness of EPOCT in association with neurological examination after elective craniotomies compared to the neurological examination alone. Studies were eligible if they provided information about the number of patients scanned, how many were asymptomatic or presented neurological deterioration before the scan and how many of each of those groups had their management changed due to imaging findings. CTs had to be performed in the first 48 h following surgery to be considered early. Eight studies were included. The retrospective studies enrolled a total of 3639 patients, with 3737 imaging examinations. Out of the 3696 CT scans performed in asymptomatic patients, less than 0.8% prompted an intervention, while 100% of patients with neurological deterioration were submitted to emergency surgery. Positive predictive values of altered scans were 0.584 for symptomatic patients and 0.125 for the asymptomatic. The number of altered scans necessary to predict (NNP) one change in management for the asymptomatic patients was 8, while for the clinically evident cases, it was 1.71. The number of scans needed to diagnose one clinically silent alteration is 134.75, and postoperative imaging of neurologically intact patients is 132 times less likely to issue an emergency intervention than an altered neurological examination alone. EPOCT following elective craniotomy in neurologically preserved patients is not supported by current evidence, and CT scanning should be performed only in particular conditions. The authors have developed an algorithm to help the judgment of each patient by the surgeon in a resource-limited context.
- Impact of a cell cycle and an extracellular matrix remodeling transcriptional signature on tumor progression and correlation with EZH2 expression in meningioma(2022) PEREIRA, Benedito Jamilson Araujo; LERARIO, Antonio Marcondes; SOLA, Paula Rodrigues; LAURENTINO, Talita de Sousa; MOHAN, Dipika R.; ALMEIDA, Antonio Nogueira de; AGUIAR, Paulo Henrique Pires de; PAIVA, Wellingson da Silva; WAKAMATSU, Alda; TEIXEIRA, Manoel Jacobsen; OBA-SHINJO, Sueli Mieko; MARIE, Suely Kazue NagahashiOBJECTIVE The authors searched for genetic and transcriptional signatures associated with tumor progression and recurrence in their cohort of patients with meningiomas, combining the analysis of targeted exome, NF2-LOH, transcrip-tome, and protein expressions. METHODS The authors included 91 patients who underwent resection of intracranial meningioma at their institution between June 2000 and November 2007. The search of somatic mutations was performed by Next Generation Sequenc-ing through a customized panel and multiplex ligation-dependent probe amplification for NF2 loss of heterozygosity. The transcriptomic profile was analyzed by QuantSeq 3 ' mRNA-Seq. The differentially expressed genes of interest were validated at the protein level analysis by immunohistochemistry.RESULTS The transcriptomic analysis identified an upregulated set of genes related to metabolism and cell cycle and downregulated genes related to immune response and extracellular matrix remodeling in grade 2 (atypical) meningio-mas, with a significant difference in recurrent compared with nonrecurrent cases. EZH2 nuclear positivity associated with grade 2, particularly with recurrent tumors and EZH2 gene expression level, correlated positively with the expres-sion of genes related to cell cycle and negatively to genes related to immune response and regulation of cell motility. CONCLUSIONS The authors identified modules of dysregulated genes in grade 2 meningiomas related to the activation of oxidative metabolism, cell division, cell motility due to extracellular remodeling, and immune evasion that were predic-tive of survival and exhibited significant correlations with EZH2 expression.
- Neuropathic pain in leprosy(2016) RAICHER, Irina; STUMP, Patrick Raymond Nicolas Andre Ghislain; BACCARELLI, Rosemari; MARCIANO, Lucia H. S. C.; URA, Somei; VIRMOND, Marcos C. L.; TEIXEIRA, Manoel Jacobsen; ANDRADE, Daniel Ciampi deNerve impairment is a key clinical aspect of leprosy and may present the distribution of mononeuropathy or multiple nerve trunks, small cutaneous nerve fibers, and free nerve endings. The clinical range of leprosy is determined by individual cell-mediated immune response to infection that also may play a role in different types of pain syndromes in leprosy. Previous studies reported a high prevalence of neuropathic pain in leprosy. In an Ethiopian study with 48 patients, pure nociceptive pain was experienced by 43% of patients and pure neuropathic pain (NeP) by 11% of patients. In an Indian study, 21.8% of leprosy patients had pain with neuropathic characteristics. These rates underlie the need to develop tools for the early diagnosis and detection of infection and its complications, such as nerve damage and pain. In a larger sample with leprosy-associated NeP (n = 90), we have applied the Douleur Neuropathique en 4 questions (DN4) and found sensitivity = 97.1% and specificity = 57.9%. The high sensitivity of this tool in leprosy patients suggests that it could be a valuable tool to screen for neuropathic pain in this population and could be used as part of health care programs aimed at detecting, treating, and rehabilitating leprosy in endemic areas.
- Simplifying the use of prognostic information in patients with traumatic brain injury(2018) SOLLA, Davi J. Fontoura; TEIXEIRA, Manoel Jacobsen; PAIVA, Wellingson Silva
conferenceObject Using color flow image to identify brain vessels during metastasis approach(2014) PASCHOAL JR., F. Mendes; OLIVEIRA, M. L. de; PICARELLI, H.; AZEVEDO, M. K.; LIMA, S. B.; BASTOS, M. F.; RIBAS, E. S. C.; TEIXEIRA, M. J.; BOR-SENG-SHU, E.bookPart Avaliação e proteção perioperatória renal(2013) MACHADO, Fábio Santana; TEIXEIRA, Manoel Jacobsenarticle Subdural hematoma as a rarecomplication of a percutaneous balloon compression: case report(2016) NETO, Sergio; NOLETO, Gustavo; DUARTE, Kleber Paiva; ROSA, Nilton Caetano da; TEIXEIRA, Manoel JacobsenBackground: Trigeminal neuralgia (TN) it's the most common of all 14 types of facial pain and it's a well-described pathology presenting as a paroxysmal (clusters of sharp lancinating) shock-like pain in abrupt crises, limited to the trigeminal domain side. We present a complication of a percutaneous balloon compression never reported before. Presentation: A 86 Years old (Y.O), Male patient on the immediate post operative of a PBC (percutaneous balloon compression) presented suddenly unresponsive and with right pupilanisocoria. Conclusion: The authors believe that the cause of the Hematoma was due to the stretch and rupture of bridging dural veins secondarily to the expansion of the balloon. The quick detection and treatment was the key for a good outcome for the patient.- Brain abnormalities in myelomeningocele patients(2020) MORAIS, Barbara Albuquerque; SOLLA, Davi Jorge Fontoura; YAMAKI, Vitor Nagai; FERRACIOLLI, Suely Fazio; ALVES, Cesar Augusto P. F.; CARDEAL, Daniel Dante; MATUSHITA, Hamilton; TEIXEIRA, Manoel JacobsenBackground Myelomeningocele (MMC) is often related to hydrocephalus and Chiari malformation (CM) type 2; however, other brain abnormalities have been reported in this population. In order to better understand and quantify other forebrain abnormalities, we analyzed magnetic resonance imaging (MRI) of MMC patients treated in utero or postnatal. Methods Between January 2014 and March 2017, 59 MMC were treated in our hospital. Thirty-seven patients (32 postnatal and 5 intrautero repair) had brain MRI and were enrolled at the study. MRI was analyzed by two experienced neuroradiologists to identify the supra and infratentorial brain abnormalities. Results A wide range of brain abnormalities was consistently identified in MMC patients. As expected, the most common were hydrocephalus (94.5%) and CM type II (89.1%). Of note, we found high incidence of corpus callosum abnormalities (86.4%), mostly represented by dysplasia (46%). Conclusions The data are consistent with the concept that brain abnormalities related to MMC can be both infratentorial and supratentorial, cortical, and subcortical. More studies are needed to correlate these forebrain abnormalities to long-term functional outcome and their prognostic value for these patients.
conferenceObject Cerebral compliance assessment using Trancranial Doppler(2018) BRASIL, S.; BOR-SENG-SHU, E.; DE-LIMA-OLIVEIRA, M.; NOGUEIRA, R.; SALINET, A.; PAIVA, W.; TEIXEIRA, M.conferenceObject Force platform analysis after deep brain stimulation of peduncolopontine nucleus in progressive supranuclear palsy: Report of one case(2015) SOUZA, C. O.; BRANT, R.; PARDINI, A. L.; BOARI, D.; TEIXEIRA, L. A.; TEIXEIRA, M. J.; BARBOSA, E. R.; FONOFF, E. T.