Morphological alterations in minor salivary glands of HTLV1+patients: A pilot study

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorVALE, Daniela Assis do
dc.contributor.authorANDRADE, Natalia Silva
dc.contributor.authorCASSEB, Jorge
dc.contributor.authorOLIVEIRA, Augusto Penalva de
dc.contributor.authorBUSSOLOTTI FILHO, Ivo
dc.contributor.authorTRIERVEILER, Marilia
dc.contributor.authorORTEGA, Karem Lopez
dc.date.accessioned2019-01-17T13:47:06Z
dc.date.available2019-01-17T13:47:06Z
dc.date.issued2018
dc.description.abstractBackground Methods Among the complex of HTLV-associated diseases, Sjogren's syndrome (SS) is one of the most controversial. This work aims to detect morphological and inflammatory alterations, including clues of the presence of HTLV-1, in minor salivary glands of patients with dryness symptoms. We have assessed HTLV-1-seropositive patients (HTLV-1 group) and patients with SS (SS group). We used formalin-fixed, paraffin-embedded minor salivary gland tissue to evaluate the morphological aspects and, by means of immunohistochemistry, the presence of Tax protein, CD4, CD8 and CD20 cells. Additionally, viral particles and proviral load were analysed by PCR. Results Conclusion The HTLV-1 group had the highest prevalence of non-specific chronic sialadenitis (85.71%; P = 0.017) and greater amount of T CD8(+) cells. In the SS group, focal lymphocytic sialadenitis (80%; P = 0.017) prevailed, with a greater amount of B CD20(+). Both immunohistochemistry and PCR identified the Tax protein and its gene in the salivary glands of both groups and in similar proportions. The results indicate that HTLV-1-seropositive patients have different patterns of morphological/inflammatory alterations, suggesting a likely difference in the process of immune activation.eng
dc.description.indexMEDLINEeng
dc.identifier.citationJOURNAL OF ORAL PATHOLOGY & MEDICINE, v.47, n.10, p.985-990, 2018
dc.identifier.doi10.1111/jop.12777
dc.identifier.eissn1600-0714
dc.identifier.issn0904-2512
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/30309
dc.language.isoeng
dc.publisherWILEYeng
dc.relation.ispartofJournal of Oral Pathology & Medicine
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright WILEYeng
dc.subjectHTLV-1eng
dc.subjectimmunophenotypeeng
dc.subjectsicca syndromeeng
dc.subjectSjogren's syndromeeng
dc.subjectTaxeng
dc.subject.othervirus type-ieng
dc.subject.othercell lymphotropic viruseng
dc.subject.otherprimary sjogrens-syndromeeng
dc.subject.otherhtlv-ieng
dc.subject.othert-cellseng
dc.subject.otherprevalenceeng
dc.subject.othermyelopathyeng
dc.subject.otherleukemiaeng
dc.subject.otherexpressioneng
dc.subject.otherantibodieseng
dc.subject.wosDentistry, Oral Surgery & Medicineeng
dc.subject.wosPathologyeng
dc.titleMorphological alterations in minor salivary glands of HTLV1+patients: A pilot studyeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalVALE, Daniela Assis do:Univ Sao Paulo, Sch Dent, Dept Stomatol, Sao Paulo, Brazil
hcfmusp.author.externalANDRADE, Natalia Silva:Univ Sao Paulo, Sch Dent, Dept Stomatol, Sao Paulo, Brazil
hcfmusp.author.externalOLIVEIRA, Augusto Penalva de:Inst Infect Dis Emilio Ribas, Sao Paulo, Brazil
hcfmusp.author.externalBUSSOLOTTI FILHO, Ivo:Irmandade Santa Casa Misericordia, Dept Otorhinolaryngol, Sao Paulo, Brazil
hcfmusp.author.externalTRIERVEILER, Marilia:Univ Sao Paulo, Sch Dent, Dept Stomatol, Sao Paulo, Brazil
hcfmusp.author.externalORTEGA, Karem Lopez:Univ Sao Paulo, Sch Dent, Dept Stomatol, Sao Paulo, Brazil
hcfmusp.citation.scopus0
hcfmusp.contributor.author-fmusphcJORGE SIMAO DO ROSARIO CASSEB
hcfmusp.description.beginpage985
hcfmusp.description.endpage990
hcfmusp.description.issue10
hcfmusp.description.volume47
hcfmusp.origemWOS
hcfmusp.origem.pubmed30175867
hcfmusp.origem.scopus2-s2.0-85053458032
hcfmusp.origem.wosWOS:000449867400009
hcfmusp.publisher.cityHOBOKENeng
hcfmusp.publisher.countryUSAeng
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