Lung transplantation: overall approach regarding its major aspects
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Citações na Scopus
10
Tipo de produção
article
Data de publicação
2015
Título da Revista
ISSN da Revista
Título do Volume
Editora
SOC BRASILEIRA PNEUMOLOGIA TISIOLOGIA
Citação
JORNAL BRASILEIRO DE PNEUMOLOGIA, v.41, n.6, p.547-553, 2015
Resumo
O transplante pulmonar é uma terapia bem estabelecida para pacientes com doença pulmonar avançada.A avaliação do candidato para o transplante é uma tarefa complexa e envolve uma equipe multidisciplinar que acompanha o paciente para além do período pós-operatório.O tempo médio atual em lista de espera para transplante pulmonar é de aproximadamente 18 meses no estado de São Paulo. Em 2014, dados da Associação Brasileira de Transplante de Órgãos mostram que 67 transplantes pulmonares foram realizados no Brasil e que 204 pacientes estavam na lista de espera para transplante pulmonar.O transplante pulmonar é principalmente indicado no tratamento de DPOC, fibrose cística, doença intersticial pulmonar, bronquiectasia não fibrocística e hipertensão pulmonar.Esta revisão abrangente teve como objetivos abordar os aspectos principais relacionados ao transplante pulmonar: indicações, contraindicações, avaliação do candidato ao transplante, avaliação do candidato doador, gestão do paciente transplantado e complicações maiores. Para atingirmos tais objetivos, utilizamos como base as diretrizes da Sociedade Internacional de Transplante de Coração e Pulmão e nos protocolos de nosso Grupo de Transplante Pulmonar localizado na cidade de São Paulo.
Lung transplantation is a well-established treatment for patients with advanced lung disease. The evaluation of a candidate for transplantation is a complex task and involves a multidisciplinary team that follows the patient beyond the postoperative period. Currently, the mean time on the waiting list for lung transplantation in the state of São Paulo, Brazil, is approximately 18 months. For Brazil as a whole, data from the Brazilian Organ Transplant Association show that, in 2014, there were 67 lung transplants and 204 patients on the waiting list for lung transplantation. Lung transplantation is most often indicated in cases of COPD, cystic fibrosis, interstitial lung disease, non-cystic fibrosis bronchiectasis, and pulmonary hypertension. This comprehensive review aimed to address the major aspects of lung transplantation: indications, contraindications, evaluation of transplant candidates, evaluation of donor candidates, management of transplant recipients, and major complications. To that end, we based our research on the International Society for Heart and Lung Transplantation guidelines and on the protocols used by our Lung Transplant Group in the city of São Paulo, Brazil.
Lung transplantation is a well-established treatment for patients with advanced lung disease. The evaluation of a candidate for transplantation is a complex task and involves a multidisciplinary team that follows the patient beyond the postoperative period. Currently, the mean time on the waiting list for lung transplantation in the state of São Paulo, Brazil, is approximately 18 months. For Brazil as a whole, data from the Brazilian Organ Transplant Association show that, in 2014, there were 67 lung transplants and 204 patients on the waiting list for lung transplantation. Lung transplantation is most often indicated in cases of COPD, cystic fibrosis, interstitial lung disease, non-cystic fibrosis bronchiectasis, and pulmonary hypertension. This comprehensive review aimed to address the major aspects of lung transplantation: indications, contraindications, evaluation of transplant candidates, evaluation of donor candidates, management of transplant recipients, and major complications. To that end, we based our research on the International Society for Heart and Lung Transplantation guidelines and on the protocols used by our Lung Transplant Group in the city of São Paulo, Brazil.
Palavras-chave
Lung transplantation, Pulmonary disease, chronic obstructive, Cystic fibrosis, Respiratory tract infections, Pulmonary fibrosis, Hypertension, pulmonary, Transplante de pulmão, Doença pulmonar obstrutiva crônica, fibrose cística, Infecções respiratórias, Fibrose pulmonar, Hipertensão pulmonar
Referências
- Todd JL, 2014, AM J RESP CRIT CARE, V189, P159, DOI 10.1164/rccm.201306-1155OC
- Botha P, 2006, J THORAC CARDIOV SUR, V131, P1154, DOI 10.1016/j.jtcvs.2005.12.037
- Pego-Fernandes PM, 2011, TRANSPL P, V43, P216, DOI 10.1016/j.transproceed.2010.12.050
- Todd JL, 2011, CHEST, V140, P502, DOI 10.1378/chest.10-2838
- Stewart S, 2007, J HEART LUNG TRANSPL, V26, P1229, DOI 10.1016/j.healun.2007.10.017
- Samano MN, 2012, TRANSPL P, V44, P2462, DOI 10.1016/j.transproceed.2012.07.134
- Casanova C, 2011, AM J RESP CRIT CARE, V184, P1015, DOI 10.1164/rccm.201105-0831OC
- Samano MN, 2009, TRANSPL P, V41, P921, DOI 10.1016/j.transproceed.2009.01.047
- Diamond JM, 2013, AM J RESP CRIT CARE, V187, P527, DOI 10.1164/rccm.201210-1865OC
- Camargo PCLB, 2014, CLINICS, V69, P51, DOI 10.6061/clinics/2014(Sup01)10
- Paraskeva M, 2013, AM J RESP CRIT CARE, V187, P1360, DOI 10.1164/rccm.201210-1831OC
- Timrott K, 2014, LANGENBECK ARCH SURG, V399, P789, DOI 10.1007/s00423-014-1193-7
- Mendeloff EN, 2002, PEDIATR TRANSPLANT, V6, P270, DOI 10.1034/j.1399-3046.2002.00217.x
- Martinu T, 2008, AM J TRANSPLANT, V8, P1498, DOI 10.1111/j.1600-6143.2008.02264.x
- Bhorade SM, 2000, J HEART LUNG TRANSPL, V19, P1199, DOI 10.1016/S1053-2498(00)00215-1
- Associacao Brasileira de Transplante de Orgaos [homepage on the Internet], 2014, REG BRAS TRANSPL 201
- de la Torre M, 2015, REV PORT PNEUMOL, V21, P36, DOI 10.1016/j.rppnen.2014.09.007
- Fishman JA, 2007, NEW ENGL J MED, V357, P2601, DOI 10.1056/NEJMra064928
- Weill D, 2015, J HEART LUNG TRANSPL, V34, P1, DOI 10.1016/j.healun.2014.06.014