Persistence and Clearance of HPV From the Penis of Men Infected and Non-Infected With HIV

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSILVA, R. J. C.
dc.contributor.authorCASSEB, J.
dc.contributor.authorANDREOLI, M. A.
dc.contributor.authorVILLA, L. L.
dc.date.accessioned2017-11-27T17:20:50Z
dc.date.available2017-11-27T17:20:50Z
dc.date.issued2011
dc.description.abstractDue to high rates of human papillomavirus (HPV) infection, the incidence of intraepithelial neoplasia and anal cancer, most studies concerning HPV in men seropositive for HIV have focused on the anal canal. Few studies have targeted the penile region in HIV-infected men. A total of 72 men seropositive for HIV and 72 men seronegative for HIV were followed-up for 6 months, and their penile exfoliated cells were tested for HPV DNA. There were no significant differences between the HIV-positive and HIV-negative men in persistence (respectively, 69.5% vs. 66.9%), clearance (respectively, 15.3% vs. 23.1%), and those men never infected with HPV during the four follow-up visits (15.2% for HIV-positive vs. 20% for HIV-negative). High-risk HPV types were detected more frequently in penile smears from men infected with HIV, while, in HIV-seronegative men, the low-risk HPV types were more abundant (P=0.001). Multiple infections with both high- and low-risk HPV types were significantly more frequent in HIV-seropositive compared to those who were HIV-seronegative (P=0.0004). The attendance rates at follow-up visits were 86%, 78%, and 58% in months 1, 2, and 6, respectively, for men infected with HIV and 93%, 72%, and 60% for the HIV-negative group. It is concluded that HIV infection can be considered a risk factor for clearance and persistence of HPV. Multiple infections with different types of HPV including high-risk HPVs are frequent in men who are infected with HIV. J. Med. Virol. 83:127-131, 2011. (C) 2010 Wiley-Liss, Inc.
dc.description.indexMEDLINE
dc.identifier.citationJOURNAL OF MEDICAL VIROLOGY, v.83, n.1, p.127-131, 2011
dc.identifier.doi10.1002/jmv.21950
dc.identifier.issn0146-6615
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/24162
dc.language.isoeng
dc.publisherWILEY-LISS
dc.relation.ispartofJournal of Medical Virology
dc.rightsrestrictedAccess
dc.rights.holderCopyright WILEY-LISS
dc.subjecthuman papillomavirus (HPV)
dc.subjectmen
dc.subjectHIV infection
dc.subjectpersistence and clearance
dc.subject.otherhuman-papillomavirus infection
dc.subject.otherhuman-immunodeficiency-virus
dc.subject.othersquamous intraepithelial lesions
dc.subject.otherhigh prevalence
dc.subject.otherbisexual men
dc.subject.otherwomen
dc.subject.otheracquisition
dc.subject.otherdeterminants
dc.subject.otherneoplasia
dc.subject.othercancer
dc.subject.wosVirology
dc.titlePersistence and Clearance of HPV From the Penis of Men Infected and Non-Infected With HIV
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalVILLA, L. L.:Hosp Alemao Oswaldo Cruz, Ludwig Inst Canc Res, Head Virol Grp, BR-01323903 Sao Paulo, Brazil
hcfmusp.citation.scopus18
hcfmusp.contributor.author-fmusphcROBERTO JOSE CARVALHO DA SILVA
hcfmusp.contributor.author-fmusphcJORGE SIMAO DO ROSARIO CASSEB
hcfmusp.description.beginpage127
hcfmusp.description.endpage131
hcfmusp.description.issue1
hcfmusp.description.volume83
hcfmusp.origemWOS
hcfmusp.origem.pubmed21108349
hcfmusp.origem.scopus2-s2.0-78649622390
hcfmusp.origem.wosWOS:000284738100018
hcfmusp.publisher.cityHOBOKEN
hcfmusp.publisher.countryUSA
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