Infiltrative growth pattern of prostate cancer is associated with lower uptake on PSMA PET and reduced diffusion restriction on mpMRI

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorLAUDICELLA, Riccardo
dc.contributor.authorRUESCHOFF, Jan H.
dc.contributor.authorFERRARO, Daniela A.
dc.contributor.authorBRADA, Muriel D.
dc.contributor.authorHAUSMANN, Daniel
dc.contributor.authorMEBERT, Iliana
dc.contributor.authorMAURER, Alexander
dc.contributor.authorHERMANNS, Thomas
dc.contributor.authorEBERLI, Daniel
dc.contributor.authorRUPP, Niels J.
dc.contributor.authorBURGER, Irene A.
dc.date.accessioned2022-10-26T14:50:07Z
dc.date.available2022-10-26T14:50:07Z
dc.date.issued2022
dc.description.abstractPurpose Recently, a significant association was shown between novel growth patterns on histopathology of prostate cancer (PCa) and prostate-specific membrane antigen (PSMA) uptake on [Ga-68]PSMA-PET. It is the aim of this study to evaluate the association between these growth patterns and ADC (mm(2)/1000 s) values in comparison to [Ga-68]PSMA uptake on PET/MRI. Methods We retrospectively evaluated patients who underwent [Ga-68]PSMA PET/MRI for staging or biopsy guidance, followed by radical prostatectomy at our institution between 07/2016 and 01/2020. The dominant lesion per patient was selected based on histopathology and correlated to PET/MRI in a multidisciplinary meeting, and quantified using SUVmax for PSMA uptake and ADC(mean) for diffusion restriction. PCa growth pattern was classified as expansive (EXP) or infiltrative (INF) according to its properties of forming a tumoral mass or infiltrating diffusely between benign glands by two independent pathologists. Furthermore, the corresponding WHO2016 ISUP tumor grade was evaluated. The t test was used to compare means, Pearson's test for categorical correlation, Cohen's kappa test for interrater agreement, and ROC curve to determine the best cutoff. Results Sixty-two patients were included (mean PSA 11.7 +/- 12.5). The interrater agreement between both pathologists was almost perfect with kappa=0.81. While 25 lesions had an EXP-growth with an ADC(mean) of 0.777 +/- 0.109, 37 showed an INF-growth with a significantly higher ADC(mean) of 1.079 +/- 0.262 (p < 0.001). We also observed a significant difference regarding PSMA SUVmax for the EXP-growth (19.2 +/- 10.9) versus the INF-growth (9.4 +/- 6.2, p < 0.001). Within the lesions encompassing the EXP- or the INF-growth, no significant correlation between the ISUP groups and ADC(mean) could be observed (p = 0.982 and p = 0.861, respectively). Conclusion PCa with INF-growth showed significantly lower SUVmax and higher ADC(mean) values compared to PCa with EXP-growth. Within the growth groups, ADC(mean) values were independent from ISUP grading.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipUniversity of Zurich
dc.description.sponsorshipJimmy Wirth Foundation
dc.description.sponsorshipHuggenberger Foundation
dc.description.sponsorshipSick Legat
dc.description.sponsorshipIten-Kohaut Foundation
dc.identifier.citationEUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, v.49, n.11, p.3917-3928, 2022
dc.identifier.doi10.1007/s00259-022-05787-9
dc.identifier.eissn1619-7089
dc.identifier.issn1619-7070
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/49567
dc.language.isoeng
dc.publisherSPRINGEReng
dc.relation.ispartofEuropean Journal of Nuclear Medicine and Molecular Imaging
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright SPRINGEReng
dc.subjectDiffusion-weighted imagingeng
dc.subjectMRIeng
dc.subjectProstate cancereng
dc.subjectPSMA PET/MRIeng
dc.subjectRadical prostatectomyeng
dc.subject.otherinternational societyeng
dc.subject.otherga-68-psma pet/cteng
dc.subject.otherlocal treatmenteng
dc.subject.otherdata systemeng
dc.subject.othertissueeng
dc.subject.othermrieng
dc.subject.othercoefficienteng
dc.subject.otherguidelineseng
dc.subject.otherdiagnosiseng
dc.subject.otheraccuracyeng
dc.subject.wosRadiology, Nuclear Medicine & Medical Imagingeng
dc.titleInfiltrative growth pattern of prostate cancer is associated with lower uptake on PSMA PET and reduced diffusion restriction on mpMRIeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryItália
hcfmusp.affiliation.countrySuíça
hcfmusp.affiliation.countryAlemanha
hcfmusp.affiliation.countryisoit
hcfmusp.affiliation.countryisoch
hcfmusp.affiliation.countryisode
hcfmusp.author.externalLAUDICELLA, Riccardo:Univ Zurich, Univ Hosp Zurich, Dept Nucl Med, Ramistr 10, CH-8091 Zurich, Switzerland; Univ Messina, Dept Biomed & Dent Sci & Morphofunct Imaging, Nucl Med Unit, Messina, Italy
hcfmusp.author.externalRUESCHOFF, Jan H.:Univ Zurich, Univ Hosp Zurich, Dept Pathol & Mol Pathol, Zurich, Switzerland
hcfmusp.author.externalBRADA, Muriel D.:Univ Zurich, Univ Hosp Zurich, Dept Pathol & Mol Pathol, Zurich, Switzerland
hcfmusp.author.externalHAUSMANN, Daniel:Kantonsspital Baden, Dept Radiol, Baden, Switzerland; Heidelberg Univ, Univ Med Ctr Mannheim, Med Fac Mannheim, Dept Clin Radiol & Nucl Med, Mannheim, Germany
hcfmusp.author.externalMEBERT, Iliana:Univ Zurich, Univ Hosp Zurich, Dept Nucl Med, Ramistr 10, CH-8091 Zurich, Switzerland; Univ Zurich, Univ Hosp Zurich, Dept Urol, Zurich, Switzerland
hcfmusp.author.externalMAURER, Alexander:Univ Zurich, Univ Hosp Zurich, Dept Nucl Med, Ramistr 10, CH-8091 Zurich, Switzerland
hcfmusp.author.externalHERMANNS, Thomas:Univ Zurich, Univ Hosp Zurich, Dept Urol, Zurich, Switzerland
hcfmusp.author.externalEBERLI, Daniel:Univ Zurich, Univ Hosp Zurich, Dept Urol, Zurich, Switzerland
hcfmusp.author.externalRUPP, Niels J.:Univ Zurich, Univ Hosp Zurich, Dept Pathol & Mol Pathol, Zurich, Switzerland
hcfmusp.author.externalBURGER, Irene A.:Univ Zurich, Univ Hosp Zurich, Dept Nucl Med, Ramistr 10, CH-8091 Zurich, Switzerland; Kantonsspital Baden, Dept Nucl Med, Baden, Switzerland
hcfmusp.citation.scopus13
hcfmusp.contributor.author-fmusphcDANIELA ANDRADE FERRARO
hcfmusp.description.beginpage3917
hcfmusp.description.endpage3928
hcfmusp.description.issue11
hcfmusp.description.volume49
hcfmusp.origemWOS
hcfmusp.origem.pubmed35435496
hcfmusp.origem.scopus2-s2.0-85128280079
hcfmusp.origem.wosWOS:000784035500001
hcfmusp.publisher.cityNEW YORKeng
hcfmusp.publisher.countryUNITED STATESeng
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