Risk Factors for Low Muscle Mass in a Population-based Prospective Cohort of Brazilian Community-dwelling Older Women: The Sao Paulo Ageing & Health (SPAH) Study

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorMACHADO, Ketty L. L. L.
dc.contributor.authorDOMICIANO, Diogo S.
dc.contributor.authorMACHADO, Luana G.
dc.contributor.authorLOPES, Jaqueline B.
dc.contributor.authorFIGUEIREDO, Camille P.
dc.contributor.authorCAPARBO, Valeria F.
dc.contributor.authorTAKAYAMA, Liliam
dc.contributor.authorMENEZES, Paulo R.
dc.contributor.authorPEREIRA, Rosa M. R.
dc.date.accessioned2020-12-16T14:53:27Z
dc.date.available2020-12-16T14:53:27Z
dc.date.issued2020
dc.description.abstractIntroduction: Sarcopenia is characterized by progressive loss of skeletal muscle mass, which results in decreased muscle strength, functional impairment, and increased risk of death. Few studies have performed a concomitant evaluation of clinical, laboratory, and body composition variables to accurately determine the contribution of each parameter to low muscle mass (LMM) in older subjects. This study aimed to identify risk factors (clinical, laboratory parameters, BMD, and body composition by DXA including visceral fat) for LMM in a prospective cohort of older Brazilian women. Methods: A total of 408 women aged >= 65 yr from the Sao Paulo Ageing & Health study were evaluated with clinical data, laboratory bone tests, BMD, and body composition by DXA using Hologic QDR 4500A equipment. Risk factors were measured at baseline (2005-2007). After a follow-up of 4.3 +/- 0.8 yr, subjects were classified according to the LMM definition of the Foundation for the National Institutes of Health criteria. LMM was defined when appendicular lean mass divided by body mass index was less than 0.512. Multivariate logistic regression models were used to identify independent risk factors for LMM. Results: At the end of follow-up, 116 women (28.4%) had LMM. Age averages were 73.3 +/- 4.9 yr in the LMM group and 72.5 +/- 4.5 yr in the normal group (p = 0.11). Mean BMI was 30.6 +/- 5.2 kg/m(2) in the LMM group and 28.1 +/- 4.7 kg/m(2) in the normal group (p < 0.001). In multivariate analyses, predictors of LMM were: falls (OR = 1.14, p = 0.016), TSH levels (OR = 1.08, p = 0.018, per 1 mu UI/L-increase), serum creatinine levels (OR =11.11, p < 0.001, per 1 mg/dL-decrease), and visceral adipose tissue (VAT) mass (OR = 1.17, p < 0.001, per 100 g increase). Conclusions: Falls, high TSH, low creatinine, and high VAT were risk factors for LMM in older women. More attention should be paid to these factors, since they are potentially reversible with adequate intervention.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipFundacao de Amparo e Pesquisa do Estado de Sao Paulo (FAPESP)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [03/09313-0, 04/12694-8, 09/15346-4]
dc.description.sponsorshipConselho Nacional de Ciencia e Tecnologia (CNPQ)National Council for Scientific and Technological Development (CNPq) [300559/2009-7]
dc.description.sponsorshipFederico Foundation (RMRP) [301805/2013-0]
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)CAPES
dc.identifier.citationJOURNAL OF CLINICAL DENSITOMETRY, v.23, n.3, p.503-510, 2020
dc.identifier.doi10.1016/j.jocd.2019.05.001
dc.identifier.eissn1559-0747
dc.identifier.issn1094-6950
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/38431
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INCeng
dc.relation.ispartofJournal of Clinical Densitometry
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright ELSEVIER SCIENCE INCeng
dc.subjectLow muscle masseng
dc.subjectwomeneng
dc.subjectvisceral adipose tissueeng
dc.subjectelderlyeng
dc.subjectbone mineral densityeng
dc.subjectrisk factorseng
dc.subject.otherbone-mineral densityeng
dc.subject.otherlow lean masseng
dc.subject.othervitamin-deng
dc.subject.othersarcopeniaeng
dc.subject.otherprevalenceeng
dc.subject.otherdefinitionseng
dc.subject.otherassociationeng
dc.subject.otherimpairmenteng
dc.subject.othermortalityeng
dc.subject.otherconsensuseng
dc.subject.wosEndocrinology & Metabolismeng
dc.titleRisk Factors for Low Muscle Mass in a Population-based Prospective Cohort of Brazilian Community-dwelling Older Women: The Sao Paulo Ageing & Health (SPAH) Studyeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalLOPES, Jaqueline B.:Univ Sao Paulo, Fac Med, Div Rheumatol, Bone Metab Lab, Sao Paulo, SP, Brazil
hcfmusp.citation.scopus4
hcfmusp.contributor.author-fmusphcKETTY LYSIE LIBARDI LIRA MACHADO
hcfmusp.contributor.author-fmusphcDIOGO SOUZA DOMICIANO
hcfmusp.contributor.author-fmusphcLUANA GERHEIM MACHADO
hcfmusp.contributor.author-fmusphcCAMILLE PINTO FIGUEIREDO
hcfmusp.contributor.author-fmusphcVALERIA DE FALCO CAPARBO
hcfmusp.contributor.author-fmusphcLILIAM TAKAYAMA GUERRA
hcfmusp.contributor.author-fmusphcPAULO ROSSI MENEZES
hcfmusp.contributor.author-fmusphcROSA MARIA RODRIGUES PEREIRA
hcfmusp.description.beginpage503
hcfmusp.description.endpage510
hcfmusp.description.issue3
hcfmusp.description.volume23
hcfmusp.origemWOS
hcfmusp.origem.pubmed31174963
hcfmusp.origem.scopus2-s2.0-85066465551
hcfmusp.origem.wosWOS:000577959700023
hcfmusp.publisher.cityNEW YORKeng
hcfmusp.publisher.countryUSAeng
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