Temporal Trends and Molecular Epidemiology of HIV Type 1 Infection in Rio de Janeiro, Brazil

Página do item simplificado
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorPIMENTEL, Victor F.
dc.contributor.authorMORGADO, Mariza G.
dc.contributor.authorBELLO, Gonzalo
dc.contributor.authorGUIMARAES, Mark D. C.
dc.contributor.authorCASTILHO, Euclides A.
dc.contributor.authorVELOSO, Valdilea G.
dc.contributor.authorGUIMARAES, Monick L.
dc.date.accessioned2016-09-09T19:20:23Z
dc.date.available2016-09-09T19:20:23Z
dc.date.issued2013
dc.description.abstractHIV-1 molecular epidemiology studies carried out in Rio de Janeiro, Brazil have identified the prevalence of subtypes B, F1 and BF1 recombinants. A high percentage of HIV-1 subtype B isolates in Rio de Janeiro harbor the GWG motif at the V3 tip (B variant) instead of the canonical GPG motif (B variant). To trace the dynamics of the HIV-1 variants over time in different exposure categories in Rio de Janeiro, the HIV-1 proviral DNA from heterosexual men (HET) and men who have sex with men (MSM) from two distinct time periods (1990-1992 and 2008-2010) were extracted, and the env-gp120 region was amplified. Neighbor-joining phylogenetic analysis was performed to determine the viral subtype, and Bayesian analysis was used to trace the HIV-1 transmission networks. A predominance of subtype B was observed in both study periods, independent of the exposure risk category. An increase of non-B subtypes was observed in the HET group, but these subtypes were maintained among the MSM group. The distribution of HIV-1 subtype B signatures in the first and second periods studied were, respectively, HET (GPG) [44.8-51.5%], (GWG) [13.8-33.3%], and (GXG) [41.4-15.2%] and MSM (GPG) [34-50%], (GWG) [55.3-30.6%], and (GXG) [10.7-19.4%]. In the first period, an association between GWG and MSM was verified while a significant reduction of this association was observed during the second period. The phylogenetic tree and the BaTS program detected the clustering of isolates only according to the B signatures but not by exposure risk category. Our findings indicate a stable prevalence of HIV-1 subtypes B and F over time in Rio de Janeiro and further suggest that the B subclade of subtype B was possibly introduced into the MSM group in this area of Brazil.
dc.description.indexMEDLINE
dc.description.sponsorshipCNPq
dc.description.sponsorshipFAPERJ
dc.identifier.citationAIDS RESEARCH AND HUMAN RETROVIRUSES, v.29, n.12, p.1553-1561, 2013
dc.identifier.doi10.1089/aid.2013.0050
dc.identifier.eissn1931-8405
dc.identifier.issn0889-2229
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/15995
dc.language.isoeng
dc.relation.ispartofAIDS Research and Human Retroviruses
dc.rightsrestrictedAccess
dc.subject.otherhuman-immunodeficiency-virus
dc.subject.othersubtype-b strains
dc.subject.otherdrug-resistance
dc.subject.othersao-paulo
dc.subject.otherslower progression
dc.subject.otherevolutionary rates
dc.subject.othersouthern brazil
dc.subject.otherv3 region
dc.subject.otherprevalence
dc.subject.otheridentification
dc.subject.wosImmunology
dc.subject.wosInfectious Diseases
dc.subject.wosVirology
dc.titleTemporal Trends and Molecular Epidemiology of HIV Type 1 Infection in Rio de Janeiro, Brazil
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalPIMENTEL, Victor F.:Inst Oswaldo Cruz, BR-20001 Rio De Janeiro, Brazil
hcfmusp.author.externalMORGADO, Mariza G.:Inst Oswaldo Cruz, BR-20001 Rio De Janeiro, Brazil
hcfmusp.author.externalBELLO, Gonzalo:Inst Oswaldo Cruz, BR-20001 Rio De Janeiro, Brazil
hcfmusp.author.externalGUIMARAES, Mark D. C.:Univ Fed Minas Gerais, Belo Horizonte, MG, Brazil
hcfmusp.author.externalVELOSO, Valdilea G.:Fiocruz MS, Evandro Chagas Res Inst, BR-21040360 Rio De Janeiro, Brazil
hcfmusp.author.externalGUIMARAES, Monick L.:Inst Oswaldo Cruz, BR-20001 Rio De Janeiro, Brazil
hcfmusp.citation.scopus10
hcfmusp.contributor.author-fmusphcEUCLIDES AYRES DE CASTILHO
hcfmusp.description.beginpage1553
hcfmusp.description.endpage1561
hcfmusp.description.issue12
hcfmusp.description.volume29
hcfmusp.origemWOS
hcfmusp.origem.pubmed23987184
hcfmusp.origem.scopus2-s2.0-84888331103
hcfmusp.origem.wosWOS:000327218000004
hcfmusp.relation.referenceAlcalde R, 2012, VIROL J, V9, DOI 10.1186/1743-422X-9-156
hcfmusp.relation.referenceAraujo AF, 2010, AIDS RES HUM RETROV, V26, P1249, DOI 10.1089/aid.2010.0068
hcfmusp.relation.referenceBello G, 2007, INFECT GENET EVOL, V7, P263, DOI 10.1016/j.meegid.2006.11.002
hcfmusp.relation.referenceBongertz V, 2000, J ACQ IMMUN DEF SYND, V23, P184
hcfmusp.relation.referenceBrazilian Ministry of Healthy, 2011, B EPIDEMIOLOGICO AID
hcfmusp.relation.referenceBrigido LFM, 2011, AIDS RES HUM RETROV, V27, P339, DOI 10.1089/aid.2010.0157
hcfmusp.relation.referenceCabral VP, 2006, MEM I OSWALDO CRUZ, V101, P881, DOI 10.1590/S0074-02762006000800010
hcfmusp.relation.referenceCaride E, 2001, VIRUS GENES, V23, P193, DOI 10.1023/A:1011812810397
hcfmusp.relation.referenceCarvalho BC, 2011, AIDS RES HUM RETROV, V27, P1081, DOI [10.1089/AID.2010.0334, 10.1089/aid.2010.0334]
hcfmusp.relation.referenceCasseb J, 1998, BRAZ J MED BIOL RES, V31, P1243, DOI 10.1590/S0100-879X1998001000002
hcfmusp.relation.referenceCasseb Jorge, 2002, International Journal of Infectious Diseases, V6, P164, DOI 10.1016/S1201-9712(02)90105-0
hcfmusp.relation.referenceCHU SY, 1992, AM J PUBLIC HEALTH, V82, P220, DOI 10.2105/AJPH.82.2.220
hcfmusp.relation.referenceCouto-Fernandez JC, 2005, MEM I OSWALDO CRUZ, V100, P73, DOI 10.1590/S0074-02762005000100014
hcfmusp.relation.referenceCouto-Fernandez JC, 2006, AIDS RES HUM RETROV, V22, P207, DOI 10.1089/aid.2006.22.207
hcfmusp.relation.referenceCovas DT, 1998, J ACQ IMMUN DEF SYND, V19, P74
hcfmusp.relation.referencede Brito A, 2006, CLIN INFECT DIS, V43, P1476
hcfmusp.relation.referenceDelatorre EO, 2012, AIDS RES HUM RETROV, V28, P1369, DOI 10.1089/aid.2011.0381
hcfmusp.relation.referenceDELWART EL, 1993, SCIENCE, V262, P1257, DOI 10.1126/science.8235655
hcfmusp.relation.referenceDiaz RS, 2008, VIROLOGY, V381, P184, DOI 10.1016/j.virol.2008.08.014
hcfmusp.relation.referenceFranca RFO, 2011, AIDS RES HUM RETROV, V27, P903, DOI [10.1089/AID.2010.0266, 10.1089/aid.2010.0266]
hcfmusp.relation.referenceGUIMARAES MDC, 1995, AM J EPIDEMIOL, V142, P538
hcfmusp.relation.referenceGuimaraes MDC, 1997, ARCH INTERN MED, V157, P1362, DOI 10.1001/archinte.157.12.1362
hcfmusp.relation.referenceGuimaraes ML, 2001, J CLIN VIROL, V21, P143, DOI 10.1016/S1386-6532(01)00158-5
hcfmusp.relation.referenceGuimaraes ML, 2010, INFECT GENET EVOL, V10, P1094, DOI 10.1016/j.meegid.2010.07.001
hcfmusp.relation.referenceGuimaraes Monick Lindenmeyer, 2002, AIDS Research and Human Retroviruses, V18, P1261, DOI 10.1089/088922202320886307
hcfmusp.relation.referenceHemelaar J, 2011, AIDS, V25, P679, DOI 10.1097/QAD.0b013e328342ff93
hcfmusp.relation.referenceKIMURA M, 1980, J MOL EVOL, V16, P111, DOI 10.1007/BF01731581
hcfmusp.relation.referenceKoichiro T., 2011, MOL BIOL EVOL, V28, P2731, DOI 10.1093/M0LBEV/MSR121
hcfmusp.relation.referenceMachado LFA, 2009, AIDS RES HUM RETROV, V25, P961, DOI 10.1089/aid.2009.0027
hcfmusp.relation.referenceMORGADO MG, 1994, AIDS RES HUM RETROV, V10, P569, DOI 10.1089/aid.1994.10.569
hcfmusp.relation.referenceMorgado MG, 1996, MEM I OSWALDO CRUZ, V91, P339, DOI 10.1590/S0074-02761996000300015
hcfmusp.relation.referenceMorgado MG, 1998, J ACQ IMMUN DEF SYND, V18, P488
hcfmusp.relation.referenceParker J, 2008, INFECT GENET EVOL, V8, P239, DOI 10.1016/j.meegid.2007.08.001
hcfmusp.relation.referencePosada D, 2008, MOL BIOL EVOL, V25, P1253, DOI 10.1093/molbev/msn083
hcfmusp.relation.referencePOTTS KE, 1993, AIDS, V7, P1191, DOI 10.1097/00002030-199309000-00007
hcfmusp.relation.referenceRay S., 2009, SIMPLOT V3 5 1
hcfmusp.relation.referenceRonquist F, 2003, BIOINFORMATICS, V19, P1572, DOI 10.1093/bioinformatics/btg180
hcfmusp.relation.referenceSABINO EC, 1994, J VIROL, V68, P6340
hcfmusp.relation.referenceSantoro-Lopes G, 2000, AIDS RES HUM RETROV, V16, P953, DOI 10.1089/08892220050058362
hcfmusp.relation.referenceSLATKIN M, 1989, GENETICS, V123, P603
hcfmusp.relation.referenceStefani MMA, 2007, J CLIN VIROL, V39, P205, DOI 10.1016/j.jcv.2007.04.012
hcfmusp.relation.referenceSucupira MC, 2012, PLOS ONE, V7
hcfmusp.relation.referenceTeixeira SLM, 2006, J MED VIROL, V78, P764, DOI 10.1002/jmv.20621
hcfmusp.relation.referenceThompson JD, 1997, NUCLEIC ACIDS RES, V25, P4876, DOI 10.1093/nar/25.24.4876
hcfmusp.relation.referenceWang TH, 2001, J VIROL, V75, P11686, DOI 10.1128/JVI.75.23.11686-11699.2001
hcfmusp.scopus.lastupdate2024-05-17
relation.isAuthorOfPublication5dfd35f7-d23f-47c6-889c-295135fb1b6a
relation.isAuthorOfPublication.latestForDiscovery5dfd35f7-d23f-47c6-889c-295135fb1b6a
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
art_PIMENTEL_Temporal_Trends_and_Molecular_Epidemiology_of_HIV_Type_2013.PDF
Tamanho:
391.06 KB
Formato:
Adobe Portable Document Format
Descrição:
publishedVersion (English)
Baixar
Coleções
Artigos e Materiais de Revistas Científicas - FM/MPR
Artigos e Materiais de Revistas Científicas - LIM/39
Artigos e Materiais de Revistas Científicas - ODS/03
Artigos e Materiais de Revistas Científicas - ODS/05