Influence of ACE Polymorphism on Echocardiographic Data of Patients with Heart Failure
Citações na Scopus
1
Tipo de produção
article
Data de publicação
2019
Título da Revista
ISSN da Revista
Título do Volume
Editora
Sociedade Brasileira de Cardiologia
Autores
Citação
INTERNATIONAL JOURNAL OF CARDIOVASCULAR SCIENCES, v.32, n.1, p.55-60, 2019
Resumo
Abstract Background: Angiotensin converting enzyme (ACE) polymorphism has been associated with different clinical and echocardiographic parameters in patients with heart failure (HF). However, no studies have been investigated such association with HF caused by Chagas disease. Objectives: To perform a genetic study to evaluate the frequency of ACE polymorphism in patients with HF caused by Chagas disease attending a university hospital in the central-west region and its association with echocardiographic findings. Methods: Descriptive study of ACE polymorphism (I/D) and echocardiographic data of 103 patients with HF caused by Chagas disease. Echocardiographic parameters were compared between the genotypes using the ANOVA test. Results: Genotypic distribution of the ACE polymorphism was 16.5% DD, 57.3% DI and 26.2% II. There was no statistically significant difference in the distribution of genotypes between men and women. The echocardiographic findings were: left ventricular ejection fraction: 43.8 ± 14.8 (DD) vs. 42.3 ± 11.6 (ID) vs. 44.9 ± 13.0 (II), p = 0.664; left ventricular diastolic diameter: 59.2 ± 9.7 (DD) vs. 60.3 ± 7.6 (ID) vs. 59.7 ± 78.1 (II), p = 0.879; left ventricular systolic diameter: 48.6 ± 12.8 (DD) vs. 50.6 ± 9.7 (ID) vs. 49.3 ± 11.9 (II), p = 0.753; and left atrial volume: 44.9 ± 10.1 (DD) vs. 40.9 ± 9.6 (ID) vs. 38.2 ± 7.8 (II), p = 0.068. Significant correlation coefficients were found for gender, age, ethnicity, heart rate and dyslipidemia. Conclusion: ACE polymorphism was not associated with echocardiographic findings in patients with HF caused by Chagas disease.
Palavras-chave
Heart Failure, Angiotensins, Polymorphism, Genetic, Chagas Disease, Echocardiography/methods
Referências
- Barker WH, 2006, CIRCULATION, V113, P799, DOI 10.1161/CIRCULATIONAHA.104.492033
- Bocchi Edimar Alcides, 2009, Arq. Bras. Cardiol., V93, P3, DOI 10.1590/S0066-782X2009002000001
- Carvalho Filho E, 2001, Rev Bras Med, V58, P394
- Carvalho Gustavo, 2011, Arq. Bras. Cardiol., V97, P408, DOI 10.1590/S0066-782X2011005000103
- Covolo L, 2003, BIOMARKERS, V8, P429, DOI 10.1080/13547500310001599052
- Cuoco MAR, 2005, INT J CARDIOL, V99, P97, DOI 10.1016/j.ijcard.2003.12.026
- Albuquerque Felipe Neves de, 2014, Arq. Bras. Cardiol., V102, P70, DOI 10.5935/abc.20130229
- de Groote P, 2004, EUR J HEART FAIL, V6, P17, DOI 10.1016/j.ejheart.2003.09.006
- Duque Gustavo Salgado, 2016, Arq. Bras. Cardiol., V107, P446, DOI 10.5935/abc.20160145
- Huang WY, 2004, EUR J HEART FAIL, V6, P23, DOI 10.1016/j.ejheart.2003.09.004
- LINDPAINTNER K, 1995, NEW ENGL J MED, V332, P706, DOI 10.1056/NEJM199503163321103
- Lopes LR, 2013, BBA-MOL BASIS DIS, V1832, P2451, DOI 10.1016/j.bbadis.2012.12.012
- Margoto Gláucia, 2009, Rev. esc. enferm. USP, V43, P44, DOI 10.1590/S0080-62342009000100006
- McNamara DM, 2004, J AM COLL CARDIOL, V44, P2019, DOI 10.1016/j.jacc.2004.08.048
- Mesquita Evandro Tinoco, 2017, Int. J. Cardiovasc. Sci., V30, P81, DOI 10.5935/2359-4802.20160060
- Murcia Laura, 2013, Enferm Infecc Microbiol Clin, V31 Suppl 1, P26, DOI 10.1016/S0213-005X(13)70111-3
- Nogueira Patrícia Resende, 2010, Arq. Bras. Cardiol., V95, P392, DOI 10.1590/S0066-782X2010005000102
- Pascuzzo-Lima C, 2009, REV ESP CARDIOL, V62, P320, DOI 10.1016/S0300-8932(09)70378-1
- Carvalho Ana Paula Perillo Ferreira, 2012, Arq. Bras. Cardiol., V99, P623, DOI 10.1590/S0066-782X2012005000056
- Porter TR, 2018, J AM SOC ECHOCARDIOG, V31, P241, DOI 10.1016/j.echo.2017.11.013
- Cuoco Marco Antonio Romeo, 2008, Arq. Bras. Cardiol., V90, P274, DOI 10.1590/S0066-782X2008000400007
- Schut AFC, 2004, EUR HEART J, V25, P2143, DOI 10.1016/j.ehj.2004.08.026
- Silva S, 2015, RBM REV BRAS MED, V72, P130
- Skrzynia C, 2015, CURR CARDIOL REV, V11, P10, DOI 10.2174/1573403X09666131117170446
- Wu CK, 2010, PHARMACOGENOMICS J, V10, P46, DOI 10.1038/tpj.2009.39
- Yang JK, 2009, J RENIN-ANGIO-ALDO S, V10, P115, DOI 10.1177/1470320309104873
- Zhang YF, 2014, J RENIN-ANGIO-ALDO S, V15, P547, DOI 10.1177/1470320313475906
- Chromossome, V17