Sex differences in dementia risk and risk factors: Individual-participant data analysis using 21 cohorts across six continents from the COSMIC consortium

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art_GONG_Sex_differences_in_dementia_risk_and_risk_factors_2023.PDF (1.14 MB)
Citações na Scopus
9
Tipo de produção
article
Data de publicação
2023
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
WILEY
Autores
GONG, Jessica
HARRIS, Katie
LIPNICKI, Darren M.
CASTRO-COSTA, Erico
LIMA-COSTA, Maria Fernanda
DINIZ, Breno S.
XIAO, Shifu
LIPTON, Richard B.
KATZ, Mindy J.
WANG, Cuiling
Citação
ALZHEIMERS & DEMENTIA, v.19, n.8, p.3365-3378, 2023
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
IntroductionSex differences in dementia risk, and risk factor (RF) associations with dementia, remain uncertain across diverse ethno-regional groups. MethodsA total of 29,850 participants (58% women) from 21 cohorts across six continents were included in an individual participant data meta-analysis. Sex-specific hazard ratios (HRs), and women-to-men ratio of hazard ratios (RHRs) for associations between RFs and all-cause dementia were derived from mixed-effect Cox models. ResultsIncident dementia occurred in 2089 (66% women) participants over 4.6 years (median). Women had higher dementia risk (HR, 1.12 [1.02, 1.23]) than men, particularly in low- and lower-middle-income economies. Associations between longer education and former alcohol use with dementia risk (RHR, 1.01 [1.00, 1.03] per year, and 0.55 [0.38, 0.79], respectively) were stronger for men than women; otherwise, there were no discernible sex differences in other RFs. DiscussionDementia risk was higher in women than men, with possible variations by country-level income settings, but most RFs appear to work similarly in women and men.
Palavras-chave
data harmonization, dementia, diversity, risk factor, sex difference
URI
https://observatorio.fm.usp.br/handle/OPI/57737
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Coleções
Artigos e Materiais de Revistas Científicas - HC/IPq
Artigos e Materiais de Revistas Científicas - LIM/23