Cardiovascular autonomic dysfunction in ""Long COVID"": pathophysiology, heart rate variability, and inflammatory markers

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorMARQUES, Karina Carvalho
dc.contributor.authorQUARESMA, Juarez Antonio Simoes
dc.contributor.authorFALCAO, Luiz Fabio Magno
dc.date.accessioned2024-04-05T19:36:29Z
dc.date.available2024-04-05T19:36:29Z
dc.date.issued2023
dc.description.abstractLong COVID is characterized by persistent signs and symptoms that continue or develop for more than 4 weeks after acute COVID-19 infection. Patients with Long COVID experience a cardiovascular autonomic imbalance known as dysautonomia. However, the underlying autonomic pathophysiological mechanisms behind this remain unclear. Current hypotheses include neurotropism, cytokine storms, and inflammatory persistence. Certain immunological factors indicate autoimmune dysfunction, which can be used to identify patients at a higher risk of Long COVID. Heart rate variability can indicate autonomic imbalances in individuals suffering from Long COVID, and measurement is a non-invasive and low-cost method for assessing cardiovascular autonomic modulation. Additionally, biochemical inflammatory markers are used for diagnosing and monitoring Long COVID. These inflammatory markers can be used to improve the understanding of the mechanisms driving the inflammatory response and its effects on the sympathetic and parasympathetic pathways of the autonomic nervous system. Autonomic imbalances in patients with Long COVID may result in lower heart rate variability, impaired vagal activity, and substantial sympathovagal imbalance. New research on this subject must be encouraged to enhance the understanding of the long-term risks that cardiovascular autonomic imbalances can cause in individuals with Long COVID.eng
dc.description.indexPubMed
dc.description.indexScopus
dc.description.indexDimensions
dc.description.indexWoS
dc.description.sponsorshipAmazon Foundation for Research Support (FAPESPA) [001]
dc.description.sponsorshipProfessional, and Technological Education (SECTET) [13/2020, 406360/2022-7]
dc.description.sponsorshipHigher Education Personnel Improvement Coordination-Brazil (CAPES)
dc.description.sponsorshipNational Council for Scientific and Technological Development-Brazil
dc.description.sponsorship[006/2020]
dc.identifier.citationFRONTIERS IN CARDIOVASCULAR MEDICINE, v.10, article ID 1256512, 11p, 2023
dc.identifier.doi10.3389/fcvm.2023.1256512
dc.identifier.issn2297-055X
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/59098
dc.language.isoeng
dc.publisherFRONTIERS MEDIA SAeng
dc.relation.ispartofFrontiers in Cardiovascular Medicine
dc.rightsopenAccesseng
dc.rights.holderCopyright FRONTIERS MEDIA SAeng
dc.subjectLong COVIDeng
dc.subjectautonomic nervous systemeng
dc.subjectautonomic diseaseseng
dc.subjectpathophysiologyeng
dc.subjectinflammationeng
dc.subjectheart rate variabilityeng
dc.subject.othersympathetic activityeng
dc.subject.othernervous-systemeng
dc.subject.otherneuroinflammationeng
dc.subject.otherbiomarkerseng
dc.subject.otherinfectioneng
dc.subject.otherfailureeng
dc.subject.otherhealthyeng
dc.subject.otherimpacteng
dc.subject.wosCardiac & Cardiovascular Systemseng
dc.titleCardiovascular autonomic dysfunction in ""Long COVID"": pathophysiology, heart rate variability, and inflammatory markerseng
dc.typearticleeng
dc.type.categoryrevieweng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalMARQUES, Karina Carvalho:State Univ Para UEPA, Ctr Biol & Hlth Sci, Belem, Para, Brazil
hcfmusp.citation.scopus5
hcfmusp.contributor.author-fmusphcJUAREZ ANTONIO SIMOES QUARESMA
hcfmusp.contributor.author-fmusphcLUIZ FABIO MAGNO FALCAO
hcfmusp.description.articlenumber1256512
hcfmusp.description.volume10
hcfmusp.origemWOS
hcfmusp.origem.dimensionspub.1163755186
hcfmusp.origem.pubmed37719983
hcfmusp.origem.scopus2-s2.0-85171335552
hcfmusp.origem.wosWOS:001066158900001
hcfmusp.publisher.cityLAUSANNEeng
hcfmusp.publisher.countrySWITZERLANDeng
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