Enteroaggregative Escherichia coli with uropathogenic characteristics are present in feces of diarrheic and healthy children

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art_NUNES_Enteroaggregative_Escherichia_coli_with_uropathogenic_characteristics_are_present_2017.PDF (1.06 MB)
Citações na Scopus
18
Tipo de produção
article
Data de publicação
2017
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
OXFORD UNIV PRESS
Autores
NUNES, Kamila O.
SANTOS, Adriana C. P.
SILVA, Rosa M.
GOMES, Tania A. T.
ELIAS, Waldir P.
Citação
PATHOGENS AND DISEASE, v.75, n.8, article ID ftx106, 4p, 2017
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Enteroaggregative Escherichia coli (EAEC) has been recently associated with urinary tract infections (UTI). Since EAEC are found in feces of both diarrheic and asymptomatic individuals, their presence in the intestine may be a source of UTI. In this study, we detected in feces of diarrheic and healthy children a subset of EAEC strains with genetic markers of extraintestinal pathogenic E. coli (ExPEC). MLST grouped these EAEC with ExPEC markers in three main clusters along with prototypes strains of EAEC, uropathogenic E. coli and UTI-causing EAEC. Interestingly, the latter cluster was composed by EAEC with ExPEC markers belonging to phylogroup A and closely related to the uropathogenic EAEC O78:H10 strain. Such attributes suggest that these strains have uropathogenic abilities. Therefore, intestinal carriers of these strains are potentially in risk to develop UTIs.
Palavras-chave
enteroaggregative E. coli, uropathogenic E. coli, virulence factors, phylogeny, bacterial infections
URI
https://observatorio.fm.usp.br/handle/OPI/25633
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MPE
Artigos e Materiais de Revistas Científicas - LIM/36