Aerobic exercise and its effects on cognition in schizophrenia

Imagem de Miniatura
Arquivos
art_FALKAI_Aerobic_exercise_and_its_effects_on_cognition_in_2017.PDF (243.87 KB)
Citações na Scopus
36
Tipo de produção
article
Data de publicação
2017
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
LIPPINCOTT WILLIAMS & WILKINS
Autores
FALKAI, Peter
MALCHOW, Berend
Citação
CURRENT OPINION IN PSYCHIATRY, v.30, n.3, p.171-175, 2017
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Purpose of review Schizophrenia is a severe neuropsychiatric disorder with incomplete remission because of negative and cognitive symptoms in a large proportion of patients. Antipsychotic medication is successful in modulating positive symptoms, but only to a lower extent negative symptoms including cognitive dysfunction. Therefore, development of innovative add-on treatment is highly needed. In this review, recent evidence from clinical studies reveals effects of aerobic exercise on cognitive deficits in schizophrenia patients. Recent findings First studies and meta-analyses on aerobic exercise in schizophrenia patients have shown effects on positive, negative, and global symptoms and cognitive domains such as global cognition, working memory, and attention. Underlying neurobiological mechanisms such as neuroplasticity-related synaptogenesis and neurogenesis have been identified in animal studies and possibly mediate effects of aerobic exercise on brain structure and function. Summary Different aspects of methods (e.g., endurance training versus yoga and Tai Chi), length and dose of the intervention, supervision of patients by sports therapists as well as maintenance of cognitive improvement after cessation of training have been raised by previous studies. However, minimal and most effective dosage of the intervention and mechanisms underlying changes in neuroplasticity need to be answered in future basic and large-scale randomized clinical trials.
Palavras-chave
aerobic exercise, cognition, schizophrenia, symptoms
URI
https://observatorio.fm.usp.br/handle/OPI/21594
Referências
  1. Adriano F, 2012, NEUROSCIENTIST, V18, P180, DOI 10.1177/1073858410395147
  2. Bhatia T, 2016, ACTA NEUROPSYCH 0812, P1
  3. Chang WC, 2014, PSYCHIAT RES, V220, P834, DOI 10.1016/j.psychres.2014.09.012
  4. Dauwan M, 2016, SCHIZOPHRENIA BULL, V42, P588, DOI 10.1093/schbul/sbv164
  5. Erickson KI, 2011, P NATL ACAD SCI USA, V108, P3017, DOI 10.1073/pnas.1015950108
  6. Firth J, 2016, SCHIZOPHR B
  7. Green MF, 1996, AM J PSYCHIAT, V153, P321
  8. Green MF, 2016, J CLIN PSYCHIAT, V77, P8, DOI 10.4088/JCP.14074su1c.02
  9. Harrisberger Fabienne, 2016, NPJ Schizophr, V2, P16033
  10. Hasan A, 2016, SCHIZOPHRENIA BULL, V42, P608, DOI 10.1093/schbul/sbv142
  11. Hasan A, 2014, WORLD J BIOL PSYCHIA, V15, P188, DOI 10.3109/15622975.2011.620002
  12. Hasan A, 2013, WORLD J BIOL PSYCHIA, V14, P2, DOI 10.3109/15622975.2012.739708
  13. Ho RTH, 2016, SCHIZOPHR RES, V171, P42, DOI 10.1016/j.schres.2016.01.038
  14. Keller-Varady K, 2016, EUR ARCH PSY CLIN N, V266, P461, DOI 10.1007/s00406-015-0651-8
  15. Kimhy D, 2016, SCHIZOPHR RES, V172, P213, DOI 10.1016/j.schres.2016.01.055
  16. Lin Jingxia, 2015, NPJ Schizophr, V1, P15047, DOI 10.1038/npjschz.2015.47
  17. Malchow B, 2016, SCHIZOPHR RES, V173, P182, DOI 10.1016/j.schres.2015.01.005
  18. Malchow B, 2015, SCHIZOPHRENIA BULL, V41, P847, DOI 10.1093/schbul/sbv020
  19. Malchow B, 2013, EUR ARCH PSY CLIN N, V263, P451, DOI 10.1007/s00406-013-0423-2
  20. Pajonk FG, 2010, ARCH GEN PSYCHIAT, V67, P133, DOI 10.1001/archgenpsychiatry.2009.193
  21. Scheewe TW, 2013, ACTA PSYCHIAT SCAND, V127, P464, DOI 10.1111/acps.12029
  22. Su CY, 2016, PSYCHIAT RES, V244, P394, DOI 10.1016/j.psychres.2016.08.011
  23. van Praag H, 1999, P NATL ACAD SCI USA, V96, P13427, DOI 10.1073/pnas.96.23.13427

Coleções
Artigos e Materiais de Revistas Científicas - LIM/27