Aerobic exercise and its effects on cognition in schizophrenia

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorFALKAI, Peter
dc.contributor.authorMALCHOW, Berend
dc.contributor.authorSCHMITT, Andrea
dc.date.accessioned2017-08-17T19:27:51Z
dc.date.available2017-08-17T19:27:51Z
dc.date.issued2017
dc.description.abstractPurpose of review Schizophrenia is a severe neuropsychiatric disorder with incomplete remission because of negative and cognitive symptoms in a large proportion of patients. Antipsychotic medication is successful in modulating positive symptoms, but only to a lower extent negative symptoms including cognitive dysfunction. Therefore, development of innovative add-on treatment is highly needed. In this review, recent evidence from clinical studies reveals effects of aerobic exercise on cognitive deficits in schizophrenia patients. Recent findings First studies and meta-analyses on aerobic exercise in schizophrenia patients have shown effects on positive, negative, and global symptoms and cognitive domains such as global cognition, working memory, and attention. Underlying neurobiological mechanisms such as neuroplasticity-related synaptogenesis and neurogenesis have been identified in animal studies and possibly mediate effects of aerobic exercise on brain structure and function. Summary Different aspects of methods (e.g., endurance training versus yoga and Tai Chi), length and dose of the intervention, supervision of patients by sports therapists as well as maintenance of cognitive improvement after cessation of training have been raised by previous studies. However, minimal and most effective dosage of the intervention and mechanisms underlying changes in neuroplasticity need to be answered in future basic and large-scale randomized clinical trials.
dc.description.indexMEDLINE
dc.description.sponsorshipDeutsche Forschungsgemeinschaft (DFG) grant: Klinische Forschergruppe (KFO) [241]
dc.description.sponsorshipDeutsche Forschungsgemeinschaft (DFG) grant: PsyCourse [FA241/16-1]
dc.description.sponsorshipEuropean Commission [Marie-Curie IN-SENS FP7-2013-PEOPLE 607616]
dc.description.sponsorshipGerman Federal Ministry of Education and Research (BMBF) through the Integrated Networks IntegraMent (Integrated Understanding of Causes and Mechanisms in Mental Disorders) under e:Med Programme [01ZX1314I SP6]
dc.description.sponsorshipESPRIT [01EE1407E]
dc.identifier.citationCURRENT OPINION IN PSYCHIATRY, v.30, n.3, p.171-175, 2017
dc.identifier.doi10.1097/YCO.0000000000000326
dc.identifier.eissn1473-6578
dc.identifier.issn0951-7367
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/21594
dc.language.isoeng
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.relation.ispartofCurrent Opinion in Psychiatry
dc.rightsrestrictedAccess
dc.rights.holderCopyright LIPPINCOTT WILLIAMS & WILKINS
dc.subjectaerobic exercise
dc.subjectcognition
dc.subjectschizophrenia
dc.subjectsymptoms
dc.subject.otherrandomized controlled-trial
dc.subject.otherphysical-exercise
dc.subject.other1st-episode
dc.subject.otherfrequency
dc.subject.othersymptoms
dc.subject.otherdeficits
dc.subject.otherimpact
dc.subject.wosPsychiatry
dc.titleAerobic exercise and its effects on cognition in schizophrenia
dc.typearticle
dc.type.categoryreview
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryAlemanha
hcfmusp.affiliation.countryisode
hcfmusp.author.externalFALKAI, Peter:Ludwig Maximilian Univ Munich, Dept Psychiat & Psychotherapy, Nussbaumstr 7, D-80336 Munich, Germany
hcfmusp.author.externalMALCHOW, Berend:Ludwig Maximilian Univ Munich, Dept Psychiat & Psychotherapy, Nussbaumstr 7, D-80336 Munich, Germany
hcfmusp.citation.scopus36
hcfmusp.contributor.author-fmusphcANDREA SCHMITT
hcfmusp.description.beginpage171
hcfmusp.description.endpage175
hcfmusp.description.issue3
hcfmusp.description.volume30
hcfmusp.origemWOS
hcfmusp.origem.pubmed28230631
hcfmusp.origem.scopus2-s2.0-85013670457
hcfmusp.origem.wosWOS:000402558800002
hcfmusp.publisher.cityPHILADELPHIA
hcfmusp.publisher.countryUSA
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