Immunogenicity decay and case incidence six months post Sinovac-CoronaVac vaccine in autoimmune rheumatic diseases patients
Carregando...
Citações na Scopus
4
Tipo de produção
article
Data de publicação
2022
Título da Revista
ISSN da Revista
Título do Volume
Editora
NATURE PORTFOLIO
Citação
NATURE COMMUNICATIONS, v.13, n.1, article ID 5801, 9p, 2022
Resumo
Characterising the response to SARS-CoV-2 post vaccination is critical in the appraisement of the induced immune response, performance and protective potential. Here the authors present data from a phase 4 clinical trial in autoimmune rheumatic disease patients 6 months post second dose of Sinovac-CoronaVac inactivated vaccine that show a marked reduction in antibody particularly in males or those under treatment with immune targeting therapies but saw no rise in COVID-19 disease. The determination of durability and vaccine-associated protection is essential for booster doses strategies, however data on the stability of SARS-CoV-2 immunity are scarce. Here we assess anti-SARS-CoV-2 immunogenicity decay and incident cases six months after the 2(nd) dose of Sinovac-CoronaVac inactivated vaccine (D210) in 828 autoimmune rheumatic diseases patients compared with 207 age/sex-balanced control individuals. The primary outcome is the presence of anti-S1/S2 SARS-CoV-2 IgG at 6 months compared to 6 weeks after 2nd vaccine dose for decay evaluation. Secondary outcomes are presence of neutralizing antibodies, percent inhibition by neutralizing, geometric mean titers and cumulative incident cases at 6 months after 2nd dose. Anti-S1/S2 IgG positivity and titers reduce to 23.8% and 38% in patients (p < 0.001) during the six-month follow up and 20% and 51% in controls (p < 0.001), respectively. Neutralizing antibodies positivity and percent inhibition declines 41% and 54% in patients (p < 0.001) and 39.7% and 47% in controls (p < 0.001). Multivariate logistic regression analysis show males (OR = 0.56;95% CI0.40-0.79), prednisone (OR = 0.56; 95% CI0.41-0.76), anti-TNF (OR = 0.66;95% CI0.45-0.96), abatacept (OR = 0.29; 95% CI0.15-0.56) and rituximab (OR = 0.32;95% CI0.11-0.90) associate with a substantial reduction in IgG response at day 210 in patients. Although cellular immunity was not assessed, a decrease of COVID-19 cases (from 27.5 to 8.1/100 person-years; p < 0.001) is observed despite the concomitant emergence and spread of the Delta variant. Altogether we show a reduction in immunity 6-months of Sinovac-CoronaVac 2nd dose, particularly in males and those under immunosuppressives therapies, without a concomitant rise in COVID-19 cases. (CoronavRheum clinicaltrials.gov:NCT04754698).
Palavras-chave
Referências
- Aikawa N. E., 2021, LANCET RHEUMATOL, DOI [10.1016/S2665-9913(21)00327-1In, DOI 10.1016/S2665-9913(21)00327-1IN]
- Aletaha D, 2010, ANN RHEUM DIS, V69, P1580, DOI [10.1136/ard.2010.138461, 10.1002/art.27584]
- [Anonymous], 2020, CORONAVIRUS B COMPLE
- AREND WP, 1990, ARTHRITIS RHEUM, V33, P1129
- Barouch DH, 2021, NEW ENGL J MED, V385, P951, DOI 10.1056/NEJMc2108829
- Bergwerk M, 2021, NEW ENGL J MED, V385, P1474, DOI 10.1056/NEJMoa2109072
- Corman VM, 2020, EUROSURVEILLANCE, V25, P23, DOI 10.2807/1560-7917.ES.2020.25.3.2000045
- Cucunawangsih C, 2021, INT J INFECT DIS, V113, P15, DOI 10.1016/j.ijid.2021.09.078
- Doria-Rose N, 2021, NEW ENGL J MED, V384, P2259, DOI 10.1056/NEJMc2103916
- Eliakim-Raz N, 2021, JAMA ONCOL, V7, P1716, DOI 10.1001/jamaoncol.2021.4390
- Jara A, 2021, NEW ENGL J MED, V385, P875, DOI 10.1056/NEJMoa2107715
- Khoury DS, 2021, NAT MED, V27, P1205, DOI 10.1038/s41591-021-01377-8
- Lamarca A. P., 2022, GENOMIC SURVEILLANCE
- LEAVITT RY, 1990, ARTHRITIS RHEUM, V33, P1101, DOI 10.1002/art.1780330807
- Levin EG, 2021, NEW ENGL J MED, V385, pE84, DOI 10.1056/NEJMoa2114583
- Lundberg IE, 2017, ANN RHEUM DIS, V76, P1955, DOI 10.1136/annrheumdis-2017-211468
- Lustig Y, 2021, LANCET RESP MED, V9, P999, DOI 10.1016/S2213-2600(21)00220-4
- McDade TW, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-96879-3
- Medeiros-Ribeiro AC, 2021, NAT MED, V27, P1744, DOI 10.1038/s41591-021-01469-5
- Miyakis S, 2006, J THROMB HAEMOST, V4, P295, DOI 10.1111/j.1538-7836.2006.01753.x
- Pegu A., 2021, BIORXIV, DOI [10.1101/2021.05.13.444010, DOI 10.1101/2021.05.13.444010]
- Petri M, 2012, ARTHRITIS RHEUM-US, V64, P2677, DOI 10.1002/art.34473
- Ribeiro AC, 2013, ARTHRIT CARE RES, V65, P476, DOI 10.1002/acr.21838
- Rudwaleit M, 2009, ANN RHEUM DIS, V68, P777, DOI 10.1136/ard.2009.108233
- Shrotri M, 2021, LANCET, V398, P385, DOI 10.1016/S0140-6736(21)01642-1
- Tadmor T, 2021, LEUKEMIA, V35, P2727, DOI 10.1038/s41375-021-01380-5
- Taylor SC, 2021, J CLIN MICROBIOL, V59, DOI 10.1128/JCM.02438-20
- Tillett W, 2012, J RHEUMATOL, V39, P154, DOI 10.3899/jrheum.110845
- van den Hoogen F, 2013, ANN RHEUM DIS, V72, P1747, DOI [10.1136/annrheumdis-2013-204424, 10.1002/art.38098]
- Vitali C, 2002, ANN RHEUM DIS, V61, P554, DOI 10.1136/ard.61.6.554
- Widge AT, 2021, NEW ENGL J MED, V384, P80, DOI 10.1056/NEJMc2032195
Coleções
Artigos e Materiais de Revistas Científicas - FM/MPE
Artigos e Materiais de Revistas Científicas - COVID-19
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/ICr
Artigos e Materiais de Revistas Científicas - HC/IOT
Artigos e Materiais de Revistas Científicas - HC/IPq
Carregar mais Artigos e Materiais de Revistas Científicas - COVID-19
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/ICr
Artigos e Materiais de Revistas Científicas - HC/IOT
Artigos e Materiais de Revistas Científicas - HC/IPq