Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC): The First Reported Case in Brazil Using Standardized Technique with the Capnopen (R) Nebulizer Device

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art_AKAISHI_Pressurized_Intraperitoneal_Aerosol_Chemotherapy_PIPAC_The_First_Reported_2021.PDF (1.5 MB)
Citações na Scopus
1
Tipo de produção
article
Data de publicação
2021
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
INT SCIENTIFIC INFORMATION, INC
Autores
SILVA, Diego Greatti Vaz da
GRAPPERON-MATHIS, Roberta Lages M.
ARAKAKI, Mariana de Souza
GALINDO, Ivan Vinicius Andrade
DAIA, Lucas Afonso
ARARUNA, Gustavo Ferreira
OLIVEIRA, Andre Luiz Torres
MANCINI, Caio Nasser
Citação
AMERICAN JOURNAL OF CASE REPORTS, v.22, article ID e933906, 7p, 2021
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Objective: setting Background: Peritoneal metastasis is a common progression of abdominal-pelvic cancers, and it is associated with poorer oncological prognosis when compared to other metastasis sites. Its treatment has limited results, mainly because of poor bioavailability of chemotherapy within the abdominal cavity after systemic administration. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) has been proposed as a novel method to deliver chemotherapy directly into the peritoneal surface; it combines the effectiveness and response of an intraperitoneal therapy with benefits of a minimally invasive approach. The laparoscopic capnoperitoneum is used to instill chemotherapy particles in a more efficient way for distribution and penetration when compared to peritoneal lavage. In the present study, we describe the first PIPAC performed in Brazil, according to the standard technique previously described with the Capnopen (R) nebulizer device, as well as technique details based on our literature review. Case Report: A 67-year-old man with pancreatic adenocarcinoma metastatic to the liver at first diagnosis underwent systemic treatment with the FOLFIRINOX protocol. After a major clinical response due to systemic treatment, pancreaticoduodenectomy was performed with resection and radiofrequency ablation of hepatic nodules. After 7 months of follow-up, the patient's condition evolved with symptomatic relapse in the peritoneum. Aiming at better control of this site, multiple PIPAC procedures were performed, showing excellent control of the peritoneal cavity disease. The patient had a sustained response in the peritoneal cavity and showed systemic disease progression 6 months after the first PIPAC procedure, which deceased at 20 months after the first PIPAC procedure and 42 months after the primary diagnosis. Conclusions: This report shows that the PIPAC procedure is reproducible elsewhere, with safety and good functional results.
Palavras-chave
Chemotherapy, Cancer, Regional Perfusion, Palliative Care, Peritoneal Neoplasms, Surgical Oncology
URI
https://observatorio.fm.usp.br/handle/OPI/43805
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MDR
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/08
Artigos e Materiais de Revistas Científicas - LIM/24
Artigos e Materiais de Revistas Científicas - ODS/03
Artigos e Materiais de Revistas Científicas - ODS/10