Preliminary outcomes of five-year survival for ovarian malignancies in profiled Serbian Oncology Centre

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorGUTIC, Bojana
dc.contributor.authorBOZANOVIC, Tatjana
dc.contributor.authorMANDIC, Aljosa
dc.contributor.authorDUGALIC, Stefan
dc.contributor.authorTODOROVIC, Jovana
dc.contributor.authorDUGALIC, Miroslava Gojnic
dc.contributor.authorSENGUL, Demet
dc.contributor.authorSENGUL, Ilker
dc.contributor.authorDETANAC, Dzemail
dc.contributor.authorKESICIOGLU, Tugrul
dc.contributor.authorJR, Jose Maria Soares
dc.date.accessioned2023-08-16T17:52:36Z
dc.date.available2023-08-16T17:52:36Z
dc.date.issued2023
dc.description.abstractObjective: The present study purposed to determine characteristics of ovarian carcinoma and to analyze predictors of survival in patients with ovarian carcinoma. Method: A retrospective cohort study was conducted including the patients with diagnosed ovarian carcinoma treated at the Clinic for Operative Oncology, Oncology Institute of Vojvodina in the period from January 2012 to December 2016. Seventy-two women with ovarian carcinoma were included in the analysis. The data about the histological type of tumor, disease stage, treatment, lymphatic infiltration, and surgical procedure were collected retrospectively, using the database of the institution where the research was conducted (BirPis 21 SRC Infonet DOO - Information System Oncology Institute of Vojvodina). Descriptive statistics and multivariate analysis using Cox proportional hazards model were performed. Results: The univariate Cox regression analysis identified histology, tumor grade, FIGO (International Federation of Gynecology and Obstetrics) stage, NACT (Neoadjuvant Chemotherapy), number of therapy cycles, type of surgery, and chemotherapy response as independent predictors of mortality. Finally, the type of tumor and chemotherapy response had an increased hazard ratio for mortality in the multivariate Cox regression model. Herewith, the percentage of high-grade, advanced-stage ovarian cancer patients with complete response to chemotherapy, absence of recurrent disease, and lymphovascular space invasion were significant predictors of survival in patients with ovarian carcinoma. Conclusions: Herein, emerging data regarding precision medicine and molecular-based personalized treatments are promising and will likely modify the way the authors provide multiple lines of treatments in the near future.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus
dc.description.indexScielo
dc.identifier.citationCLINICS, v.78, article ID 100204, 5p, 2023
dc.identifier.doi10.1016/j.clinsp.2023.100204
dc.identifier.eissn1980-5322
dc.identifier.issn1807-5932
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/54733
dc.language.isoeng
dc.publisherELSEVIER ESPANAeng
dc.relation.ispartofClinics
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright ELSEVIER ESPANAeng
dc.subjectOvaryeng
dc.subjectCarcinomaeng
dc.subjectOncologyeng
dc.subjectHistopathologyeng
dc.subjectPathologyeng
dc.subject.othercancereng
dc.subject.otherriskeng
dc.subject.otherexpressioneng
dc.subject.othermechanismeng
dc.subject.otherwomeneng
dc.subject.wosMedicine, General & Internaleng
dc.titlePreliminary outcomes of five-year survival for ovarian malignancies in profiled Serbian Oncology Centreeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countrySérvia
hcfmusp.affiliation.countryisors
hcfmusp.author.externalGUTIC, Bojana:Univ Novi Sad, Oncol Inst Vojvodina, Sremska Kamen, Fac Med, Novi Sad, Serbia; Univ Belgrade, Fac Med, Belgrade, Serbia
hcfmusp.author.externalBOZANOVIC, Tatjana:Univ Belgrade, Univ Clin Ctr Serbia, Dept Gynecol & Obstet, Clin Gynecol & Obstet,Fac Med, Belgrade, Serbia
hcfmusp.author.externalMANDIC, Aljosa:Univ Novi Sad, Oncol Inst Vojvodina, Sremska Kamen, Fac Med, Novi Sad, Serbia; Univ Belgrade, Fac Med, Belgrade, Serbia
hcfmusp.author.externalDUGALIC, Stefan:Univ Belgrade, Univ Clin Ctr Serbia, Dept Gynecol & Obstet, Clin Gynecol & Obstet,Fac Med, Belgrade, Serbia
hcfmusp.author.externalTODOROVIC, Jovana:Univ Belgrade, Inst Social Med, Belgrade, Serbia
hcfmusp.author.externalDUGALIC, Miroslava Gojnic:Univ Belgrade, Univ Clin Ctr Serbia, Dept Gynecol & Obstet, Clin Gynecol & Obstet,Fac Med, Belgrade, Serbia
hcfmusp.author.externalSENGUL, Demet:Giresun Univ, Fac Med, Dept Pathol, Giresun, Turkiye
hcfmusp.author.externalSENGUL, Ilker:Gen Hosp Novi Pazar, Dept Ophthalmol, Novi Pazar, Serbia; Giresun Univ, Fac Med, Div Endocrine Surg, Giresun, Turkiye
hcfmusp.author.externalDETANAC, Dzemail:Gen Hosp Novi Pazar, Dept Gen Surg, Novi Pazar, Serbia
hcfmusp.citation.scopus1
hcfmusp.contributor.author-fmusphcJOSE MARIA SOARES JUNIOR
hcfmusp.description.articlenumber100204
hcfmusp.description.volume78
hcfmusp.origemWOS
hcfmusp.origem.pubmed37148829
hcfmusp.origem.scieloSCIELO:S1807-59322023000100239
hcfmusp.origem.scopus2-s2.0-85154590754
hcfmusp.origem.wosWOS:000999701400001
hcfmusp.publisher.cityMADRIDeng
hcfmusp.publisher.countrySPAINeng
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