Effects of bovine leukemia virus infection on milk neutrophil function and the milk lymphocyte profile

Página do item simplificado
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorLIBERA, Alice Maria Melville Paiva Della
dc.contributor.authorSOUZA, Fernando Nogueira de
dc.contributor.authorBATISTA, Camila Freitas
dc.contributor.authorSANTOS, Bruna Parapinski
dc.contributor.authorAZEVEDO, Luis Fernando Fernandes de
dc.contributor.authorSANCHEZ, Eduardo Milton Ramos
dc.contributor.authorDINIZ, Soraia Araujo
dc.contributor.authorSILVA, Marcos Xavier
dc.contributor.authorHADDAD, Joao Paulo
dc.contributor.authorBLAGITZ, Maiara Garcia
dc.date.accessioned2015-07-01T21:18:19Z
dc.date.available2015-07-01T21:18:19Z
dc.date.issued2015
dc.description.abstractThe effects of bovine leukemia virus (BLV) on the immune response have been extensively investigated; however, its effects on mammary gland immunity are only speculative. Although BLV has a tropism for B cells, it can affect both adaptive and innate immunities because these systems share many effector mechanisms. This scenario is the basis of this investigation of the effects of BLV on mammary gland immunity, which is largely dependent upon neutrophilic functions. Thus, the present study sought to examine neutrophilic functions and the lymphocyte profile in the milk of naturally BLV-infected cows. The viability of the milk neutrophils and the percentage of milk neutrophils that produced reactive oxygen species (ROS) or phagocytosed Staphylococcus aureus were similar between BLV-infected and BLV-uninfected dairy cows. Furthermore, the expression of CD62L and CD11b by the milk neutrophils and the percentage of milk neutrophils (CH138(+) cells) that were obtained from the udder quarters of the BLV-infected cows were not altered. Conversely, the median fluorescence intensity (MFI) representing intracellular ROS production and the phagocytosis of S. aureus, the expression of CD44 by the milk neutrophils and the percentage of apoptotic B cells were lower in the milk cells from BLV-infected dairy cows, particularly those from animals with persistent lymphocytosis (PL). The lymphocyte subsets were not different among the groups, with the exception of the percentage of CD5-/CD11b(-) B cells, which was higher in the milk cells from BLV-infected cows, particularly those with PL. Thus, the present study provides novel insight into the implications of BLV infection for mammary gland immunity.
dc.description.indexMEDLINE
dc.description.sponsorshipSao Paulo State Research Foundation [2009/50672-0]
dc.identifier.citationVETERINARY RESEARCH, v.46, article ID 2, 8p, 2015
dc.identifier.doi10.1186/s13567-014-0125-4
dc.identifier.eissn1297-9716
dc.identifier.issn0928-4249
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/9614
dc.language.isoeng
dc.publisherBIOMED CENTRAL LTD
dc.relation.ispartofVeterinary Research
dc.rightsopenAccess
dc.rights.holderCopyright BIOMED CENTRAL LTD
dc.subject.othersomatic-cell counts
dc.subject.otherleukosis virus
dc.subject.otherdairy-cows
dc.subject.otherb-cells
dc.subject.otherperipheral-blood
dc.subject.othermammary-gland
dc.subject.otherpersistent lymphocytosis
dc.subject.othersubclinical mastitis
dc.subject.othermanagement-practices
dc.subject.othercoliform mastitis
dc.subject.wosVeterinary Sciences
dc.titleEffects of bovine leukemia virus infection on milk neutrophil function and the milk lymphocyte profile
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalLIBERA, Alice Maria Melville Paiva Della:Univ Sao Paulo, Fac Med Vet & Zootecnia, Dept Clin Med, BR-05508270 Sao Paulo, Brazil
hcfmusp.author.externalSOUZA, Fernando Nogueira de:Univ Fed Minas Gerais, Escola Vet, Dept Med Vet Prevent, BR-31270010 Belo Horizonte, MG, Brazil
hcfmusp.author.externalBATISTA, Camila Freitas:Univ Sao Paulo, Fac Med Vet & Zootecnia, Dept Clin Med, BR-05508270 Sao Paulo, Brazil
hcfmusp.author.externalSANTOS, Bruna Parapinski:Univ Sao Paulo, Fac Med Vet & Zootecnia, Dept Clin Med, BR-05508270 Sao Paulo, Brazil
hcfmusp.author.externalAZEVEDO, Luis Fernando Fernandes de:Univ Sao Paulo, Fac Med Vet & Zootecnia, Dept Clin Med, BR-05508270 Sao Paulo, Brazil
hcfmusp.author.externalDINIZ, Soraia Araujo:Univ Fed Minas Gerais, Escola Vet, Dept Med Vet Prevent, BR-31270010 Belo Horizonte, MG, Brazil
hcfmusp.author.externalSILVA, Marcos Xavier:Univ Fed Minas Gerais, Escola Vet, Dept Med Vet Prevent, BR-31270010 Belo Horizonte, MG, Brazil
hcfmusp.author.externalHADDAD, Joao Paulo:Univ Fed Minas Gerais, Escola Vet, Dept Med Vet Prevent, BR-31270010 Belo Horizonte, MG, Brazil
hcfmusp.author.externalBLAGITZ, Maiara Garcia:Univ Sao Paulo, Fac Med Vet & Zootecnia, Dept Clin Med, BR-05508270 Sao Paulo, Brazil
hcfmusp.citation.scopus42
hcfmusp.contributor.author-fmusphcEDUARDO MILTON RAMOS SANCHEZ
hcfmusp.description.articlenumber2
hcfmusp.description.volume46
hcfmusp.origemWOS
hcfmusp.origem.pubmed25595200
hcfmusp.origem.scopus2-s2.0-84924058986
hcfmusp.origem.wosWOS:000349255800001
hcfmusp.publisher.cityLONDON
hcfmusp.publisher.countryENGLAND
hcfmusp.relation.referenceAlvarez I, 2013, AM J VET RES, V74, P744, DOI 10.2460/ajvr.74.5.744
hcfmusp.relation.referenceBerland R, 2002, ANNU REV IMMUNOL, V20, P253, DOI 10.1146/annurev.immunol.20.100301.064833
hcfmusp.relation.referenceBlagitz MG, 2013, J DAIRY SCI, V96, P3750, DOI 10.3168/jds.2012-6370
hcfmusp.relation.referenceBojarojc-Nosowicz B, 2006, ARCH TIERZUCHT, V49, P17
hcfmusp.relation.referenceCantor GH, 2001, J VIROL, V75, P1689, DOI 10.1128/JVI.75.4.1689-1696.2001
hcfmusp.relation.referenceDA Y, 1993, P NATL ACAD SCI USA, V90, P6538, DOI 10.1073/pnas.90.14.6538
hcfmusp.relation.referenceD'Angelino JL, 1998, J DAIRY RES, V65, P693, DOI 10.1017/S0022029998003124
hcfmusp.relation.referenceDebacq C, 2003, J VIROL, V77, P13073, DOI 10.1128/JVI.77.24.13073-13083.2003
hcfmusp.relation.referenceSouza Fernando Nogueira de, 2012, J Vet Med Sci, V74, P221
hcfmusp.relation.referenceDella Libera AMMP, 2012, SEMIN-CIENC AGRAR, V33, P1487, DOI 10.5433/1679-0359.2012v33n4p1487
hcfmusp.relation.referenceDiez-Fraile A, 2003, VET RES, V34, P57, DOI 10.1051/vetres:2002053
hcfmusp.relation.referenceDivers TJ, 2008, REBHUNNS DIS DAIRY C
hcfmusp.relation.referenceElazar S, 2010, VET RES, V41, DOI 10.1051/vetres/2010025
hcfmusp.relation.referenceEMANUELSON U, 1992, PREV VET MED, V12, P121, DOI 10.1016/0167-5877(92)90075-Q
hcfmusp.relation.referenceErskine RJ, 2012, J DAIRY SCI, V95, P727, DOI 10.3168/jds.2011-4760
hcfmusp.relation.referenceErskine RJ, 2011, AM J VET RES, V72, P1059, DOI 10.2460/ajvr.72.8.1059
hcfmusp.relation.referenceFlaming KP, 1997, VET IMMUNOL IMMUNOP, V56, P27, DOI 10.1016/S0165-2427(96)05730-3
hcfmusp.relation.referenceFlorins A, 2007, FRONT BIOSCI, V12, P1520, DOI 10.2741/2165
hcfmusp.relation.referenceFlorins A, 2008, VET IMMUNOL IMMUNOP, V125, P1, DOI 10.1016/j.vetimm.2008.04.007
hcfmusp.relation.referenceGATEI MH, 1989, VET IMMUNOL IMMUNOP, V23, P139, DOI 10.1016/0165-2427(89)90116-5
hcfmusp.relation.referenceGillet N, 2007, RETROVIROLOGY, V4, DOI 10.1186/1742-4690-4-18
hcfmusp.relation.referenceGonen E, 2008, VET RES, V39, DOI 10.1051/vetres:2008005
hcfmusp.relation.referenceHASUI M, 1989, J IMMUNOL METHODS, V117, P53, DOI 10.1016/0022-1759(89)90118-X
hcfmusp.relation.referenceIkebuchi R, 2011, VET RES, V42, DOI 10.1186/1297-9716-42-103
hcfmusp.relation.referenceIkebuchi R, 2013, VET RES, V44, DOI 10.1186/1297-9716-44-59
hcfmusp.relation.referenceJACOBS RM, 1995, CAN J VET RES, V59, P271
hcfmusp.relation.referenceJuliarena MA, 2007, AM J VET RES, V68, P1220, DOI 10.2460/ajvr.68.11.1220
hcfmusp.relation.referenceKaczmarczyk Ewa, 2005, Journal of Applied Genetics, V46, P59
hcfmusp.relation.referenceKawai K, 2005, J ALLERGY CLIN IMMUN, V116, P192, DOI 10.1016/j.jaci.2005.03.021
hcfmusp.relation.referenceKoess C, 2008, J DAIRY RES, V75, P225, DOI 10.1017/S0022029908003245
hcfmusp.relation.referenceMarinho J, 2005, JAIDS-J ACQ IMM DEF, V40, P625, DOI 10.1097/01.qai.0000174252.73516.7a
hcfmusp.relation.referenceMehrzad J, 2004, J DAIRY SCI, V87, P4150
hcfmusp.relation.referenceMehrzad J, 2005, VET RES, V36, P101, DOI 10.1051/vetres:2004055
hcfmusp.relation.referenceOkagawa T, 2012, VET RES, V43, DOI 10.1186/1297-9716-43-45
hcfmusp.relation.referenceOliver SP, 2004, MICROBIOLOGICAL PROC
hcfmusp.relation.referenceOtt SL, 2003, PREV VET MED, V61, P249, DOI 10.1016/j.prevetmed.2003.08.003
hcfmusp.relation.referencePaape MJ, 2003, VET RES, V34, P597, DOI 10.1051/vetres:2003024
hcfmusp.relation.referencePiepers S, 2009, J DAIRY SCI, V92, P626, DOI 10.3168/jds.2008-1393
hcfmusp.relation.referencePiepers S, 2013, J DAIRY RES, V80, P309, DOI 10.1017/S0022029913000228
hcfmusp.relation.referencePiepers S, 2007, J DAIRY RES, V74, P478, DOI 10.1017/S0022029907002841
hcfmusp.relation.referenceRADEMACHER R, 1977, VET MED-CZECH, V22, P673
hcfmusp.relation.referenceRainard P, 2006, VET RES, V37, P369, DOI 10.1051/vetres:2006007
hcfmusp.relation.referenceRinaldi M, 2010, VET IMMUNOL IMMUNOP, V138, P267, DOI 10.1016/j.vetimm.2010.10.005
hcfmusp.relation.referenceRusov V, 1994, VET GLASNIK, V48, P303
hcfmusp.relation.referenceSandev Nikolay, 2004, Veterinarski Arhiv, V74, P411
hcfmusp.relation.referenceSargeant JM, 1997, PREV VET MED, V31, P211, DOI 10.1016/S0167-5877(96)01140-3
hcfmusp.relation.referenceSchepers AJ, 1997, J DAIRY SCI, V80, P1833
hcfmusp.relation.referenceSchukken YH, 2003, VET RES, V34, P579, DOI 10.1051/vetres:2003028
hcfmusp.relation.referenceSchwartzCornil I, 1997, J GEN VIROL, V78, P153
hcfmusp.relation.referenceSladek Z, 2009, RES VET SCI, V86, P235, DOI 10.1016/j.rvsc.2008.07.016
hcfmusp.relation.referenceSORDILLO LM, 1991, VET IMMUNOL IMMUNOP, V27, P393, DOI 10.1016/0165-2427(91)90034-A
hcfmusp.relation.referenceSouza FN, 2011, ARQ BRAS MED VET ZOO, V63, P1124, DOI 10.1590/S0102-09352011000500012
hcfmusp.relation.referenceSouza FN, 2012, AM J IMMUNOL, V8, P166
hcfmusp.relation.referenceSuzuki S, 2013, MICROBIOL IMMUNOL, V57, P600, DOI 10.1111/1348-0421.12073
hcfmusp.relation.referenceTakahashi M, 2004, MICROBES INFECT, V6, P584, DOI [10.1016/j.micinf..2004.02.014, 10.1016/j.micinf.2004.02.014]
hcfmusp.relation.referenceTAKAMATSU H, 1988, VET IMMUNOL IMMUNOP, V18, P349, DOI 10.1016/0165-2427(88)90161-4
hcfmusp.relation.referenceTAYLOR BC, 1992, VET IMMUNOL IMMUNOP, V31, P35, DOI 10.1016/0165-2427(92)90085-5
hcfmusp.relation.referenceTHURMOND MC, 1990, AM J VET RES, V51, P466
hcfmusp.relation.referenceTrainin Z, 1996, VET IMMUNOL IMMUNOP, V56, P39
hcfmusp.relation.referenceVachon E, 2006, BLOOD, V107, P4149, DOI 10.1182/blood-2005-09-3808
hcfmusp.relation.referenceVanLeeuwen JA, 2010, PREV VET MED, V93, P129, DOI 10.1016/j.prevetmed.2009.11.013
hcfmusp.relation.referenceVan Oostveldt K, 2002, DOMEST ANIM ENDOCRIN, V22, P37, DOI 10.1016/S0739-7240(01)00115-1
hcfmusp.relation.referenceVerdonck K, 2008, EPIDEMIOL INFECT, V136, P1076, DOI 10.1017/S0950268807009521
hcfmusp.relation.referenceWALKER AF, 1987, VET IMMUNOL IMMUNOP, V14, P67, DOI 10.1016/0165-2427(87)90075-4
hcfmusp.relation.referenceWellenberg GJ, 2002, VET MICROBIOL, V88, P27, DOI 10.1016/S0378-1135(02)00098-6
hcfmusp.relation.referenceWILLIAMS DL, 1988, AM J VET RES, V49, P1098
hcfmusp.relation.referenceWu D, 1999, J COMP PATHOL, V120, P117, DOI 10.1053/jcpa.1998.0259
hcfmusp.relation.referenceYakobson B, 2000, COMP IMMUNOL MICROB, V23, P197, DOI 10.1016/S0147-9571(99)00074-0
hcfmusp.relation.referenceYoshikawa H, 1997, J VET MED SCI, V59, P301, DOI 10.1292/jvms.59.301
hcfmusp.scopus.lastupdate2024-05-10
relation.isAuthorOfPublicationaccd834f-a555-4cb8-a3fe-4a129d4bd661
relation.isAuthorOfPublication.latestForDiscoveryaccd834f-a555-4cb8-a3fe-4a129d4bd661
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
art_LIBERA_Effects_of_bovine_leukemia_virus_infection_on_milk_2015.PDF
Tamanho:
411.88 KB
Formato:
Adobe Portable Document Format
Descrição:
publishedVersion (English)
Baixar
Coleções
Artigos e Materiais de Revistas Científicas - LIM/38