Predictors of Obstructive Sleep Apnea in Consecutive Patients with Metabolic Syndrome
Carregando...
Citações na Scopus
4
Tipo de produção
article
Data de publicação
2018
Título da Revista
ISSN da Revista
Título do Volume
Editora
MARY ANN LIEBERT, INC
Autores
PEDROSA, Rodrigo P.
FRAGA, Raffael F.
RONDON, Maria U.
Citação
METABOLIC SYNDROME AND RELATED DISORDERS, v.16, n.1, p.2-5, 2018
Resumo
Background: Recent evidence suggests that obstructive sleep apnea (OSA) is common in patients with metabolic syndrome (MetS) and may contribute to metabolic deregulation, inflammation, and atherosclerosis in these patients. In clinical practice, however, OSA is frequently underdiagnosed. We sought to investigate the clinical predictors of OSA in patients with MetS. Methods: We studied consecutive patients newly diagnosed with MetS (Adult Treatment Panel-III). All participants underwent clinical evaluation, standard polysomnography, and laboratory measurements. We performed a logistic regression model, including the following variables: gender, age >50 years, neck and waist circumferences, hypertension, diabetes, body mass index (BMI) >30kg/m(2), high risk for OSA by Berlin questionnaire, presence of excessive daytime somnolence (Epworth Sleepiness Scale), abnormal serum glucose, triglycerides, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol. Results: We studied 197 patients (60% men; age: 4910 years; BMI: 32.9 +/- 5.1kg/m(2)). OSA (defined by an apnea-hypopnea index 15 events per hour) was diagnosed in 117 patients [59%; 95% confidence interval (CI): 52-66]. In multivariate analysis, male gender [odds ratio (OR): 3.28; 95% CI: 1.68-6.41; P<0.01], abnormal glucose levels (OR: 3.01; 95% CI: 1.50-6.03; P<0.01), excessive daytime sleepiness (OR: 2.38; 95% CI: 1.13-5.04; P=0.02), and high risk for OSA by Berlin questionnaire (OR: 4.33; 95% CI: 2.06-9.11; P<0.001) were independently associated with OSA. Conclusions: Simple clinical and metabolic characteristics may help to improve the underdiagnosis of OSA in patients with MetS.
Palavras-chave
obstructive sleep apnea, metabolic syndrome, diagnosis
Referências
- Chowdhuri S, 2016, AM J RESP CRIT CARE, V193, pE37, DOI 10.1164/rccm.201602-0361ST
- Drager LF, 2013, J AM COLL CARDIOL, V62, P569, DOI 10.1016/j.jacc.2013.05.045
- Drager LF, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0012065
- Drager LF, 2010, AM J CARDIOL, V105, P1135, DOI 10.1016/j.amjcard.2009.12.017
- Drager LF, 2010, ATHEROSCLEROSIS, V208, P490, DOI 10.1016/j.atherosclerosis.2009.08.016
- Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032
- Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
- Heinzer R, 2015, LANCET RESP MED, V3, P310, DOI 10.1016/S2213-2600(15)00043-0
- HORNER RL, 1989, Q J MED, V72, P719
- Isono S, 2012, RESPIROLOGY, V17, P32, DOI 10.1111/j.1440-1843.2011.02093.x
- JOHNS MW, 1991, SLEEP, V14, P540, DOI 10.1093/sleep/14.6.540
- Netzer NC, 1999, ANN INTERN MED, V131, P485, DOI 10.7326/0003-4819-131-7-199910050-00002
- Papanas N, 2010, VASC HEALTH RISK MAN, V6, P281
- Pedrosa RP, 2011, HYPERTENSION, V58, P811, DOI 10.1161/HYPERTENSIONAHA.111.179788
- Rogers A, 2015, J OBES OVERWEIGHT, V1, P1104
- SHELTON KE, 1993, AM REV RESPIR DIS, V148, P462, DOI 10.1164/ajrccm/148.2.462
- Souza MJ, 2017, DIABETES METAB, V17, P30036