Cellular components of the idiopathic epiretinal membrane

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSILVA, Rafael Andre da
dc.contributor.authorRODA, Vinicius Moraes de Paiva
dc.contributor.authorMATSUDA, Monique
dc.contributor.authorSIQUEIRA, Paula Veloso
dc.contributor.authorLUSTOZA-COSTA, Gabriela Jesus
dc.contributor.authorWU, Davi Chen
dc.contributor.authorHAMASSAKI, Dania Emi
dc.date.accessioned2022-06-20T15:44:43Z
dc.date.available2022-06-20T15:44:43Z
dc.date.issued2022
dc.description.abstractIdiopathic epiretinal membrane (iERM) is a fibrocellular proliferation on the inner surface of the retina, which leads to decreased visual acuity and even central visual loss. As iERM is associated to advanced age and posterior vitreous detachment, a higher prevalence is expected with increasing life expectancy and aging of the global population. Although various cell types of retinal and extra-retinal origin have been described in iERMs (Muller glial cells, astrocytes, hyalocytes, retinal pigment epithelium cells, myofibroblasts, and fibroblasts), myofibroblasts have a central role in collagen production and contractile activity. Thus, myofibroblast differentiation is considered a key event for the iERM formation and progression, and fibroblasts, Muller glial cells, hyalocytes, and retinal pigment epithelium have been identified as myofibroblast precursors. On the other side, the different cell types synthesize growth factors, cytokines, and extracellular matrix, which have a crucial role in ERM pathogenesis. In the present review, the major cellular components and their functions are summarized, and their possible roles in the iERM formation are discussed. By exploring in detail the cellular and molecular aspects of iERM, we seek to contribute for better understanding of this fibrotic disease and the origin of myofibroblasts, which may eventually drive to more targeted therapeutic approaches.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipSao Paulo Research Foundation-Brazil (FAPESP) [15/2150-2]
dc.description.sponsorshipNational Council of Scientific and Technological Development-Brazil (CNPq) [310402/2017-4]
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior-Brazil (CAPES) [001]
dc.identifier.citationGRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, v.260, n.5, p.1435-1444, 2022
dc.identifier.doi10.1007/s00417-021-05492-7
dc.identifier.eissn1435-702X
dc.identifier.issn0721-832X
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/47473
dc.language.isoeng
dc.publisherSPRINGEReng
dc.relation.ispartofGraefes Archive for Clinical and Experimental Ophthalmology
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright SPRINGEReng
dc.subjectEpiretinal membraneeng
dc.subjectHyalocyteeng
dc.subjectMuller celleng
dc.subjectMyofibroblasteng
dc.subjectRetinal pigment epithelium celleng
dc.subjectTransdifferentiationeng
dc.subject.otherproliferative vitreoretinal diseaseseng
dc.subject.othergrowth-factoreng
dc.subject.othermuller cellseng
dc.subject.othertgf-betaeng
dc.subject.otherhyalocyteseng
dc.subject.othertissueeng
dc.subject.otheroverexpressioneng
dc.subject.otherdetachmenteng
dc.subject.othercollagenseng
dc.subject.othergliaeng
dc.subject.wosClinical Neurologyeng
dc.titleCellular components of the idiopathic epiretinal membraneeng
dc.typearticleeng
dc.type.categoryrevieweng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalSILVA, Rafael Andre da:Univ Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, BR-05508000 Sao Paulo, SP, Brazil
hcfmusp.author.externalRODA, Vinicius Moraes de Paiva:Univ Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, BR-05508000 Sao Paulo, SP, Brazil
hcfmusp.author.externalSIQUEIRA, Paula Veloso:Univ Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, BR-05508000 Sao Paulo, SP, Brazil
hcfmusp.author.externalLUSTOZA-COSTA, Gabriela Jesus:Univ Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, BR-05508000 Sao Paulo, SP, Brazil
hcfmusp.author.externalWU, Davi Chen:Univ Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, BR-05508000 Sao Paulo, SP, Brazil; Irmandade Misericordia Santa Casa Sao Paulo, Dept Ophthalmol, Sao Paulo, SP, Brazil
hcfmusp.author.externalHAMASSAKI, Dania Emi:Univ Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, BR-05508000 Sao Paulo, SP, Brazil
hcfmusp.citation.scopus16
hcfmusp.contributor.author-fmusphcMONIQUE MATSUDA
hcfmusp.description.beginpage1435
hcfmusp.description.endpage1444
hcfmusp.description.issue5
hcfmusp.description.volume260
hcfmusp.origemWOS
hcfmusp.origem.pubmed34842983
hcfmusp.origem.scopus2-s2.0-85120060600
hcfmusp.origem.wosWOS:000723577300001
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hcfmusp.publisher.countryUNITED STATESeng
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