The Promigratory Activity of the Matricellular Protein Galectin-3 Depends on the Activation of PI-3 Kinase

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art_MELO_The_Promigratory_Activity_of_the_Matricellular_Protein_Galectin3_2011.PDF (3.57 MB)
Citações na Scopus
16
Tipo de produção
article
Data de publicação
2011
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
PUBLIC LIBRARY SCIENCE
Autores
MELO, Fabiana H. M.
BUTERA, Diego
HSU, Daniel K.
SILVA, Ana Maria Moura da
LIU, Fu-Tong
SANTOS, Marinilice F.
Citação
PLOS ONE, v.6, n.12, article ID e29313, 11p, 2011
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Expression of galectin-3 is associated with sarcoma progression, invasion and metastasis. Here we determined the role of extracellular galectin-3 on migration of sarcoma cells on laminin-111. Cell lines from methylcholanthrene-induced sarcomas from both wild type and galectin-3(-/-) mice were established. Despite the presence of similar levels of laminin-binding integrins on the cell surface, galectin-3(-/-) sarcoma cells were more adherent and less migratory than galectin-3+/+ sarcoma cells on laminin-111. When galectin-3 was transiently expressed in galectin-3(-/-) sarcoma cells, it inhibited cell adhesion and stimulated the migratory response to laminin in a carbohydrate-dependent manner. Extracellular galectin-3 led to the recruitment of SHP-2 phosphatase to focal adhesion plaques, followed by a decrease in the amount of phosphorylated FAK and phospho-paxillin in the lamellipodia of migrating cells. The promigratory activity of extracellular galectin-3 was inhibitable by wortmannin, implicating the activation of a PI-3 kinase dependent pathway in the galectin-3 triggered disruption of adhesion plaques, leading to sarcoma cell migration on laminin-111.
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URI
https://observatorio.fm.usp.br/handle/OPI/22874
Referências
  1. Ahmad N, 2004, J BIOL CHEM, V279, P10841, DOI 10.1074/jbc.M312834200
  2. Sano H, 2000, J IMMUNOL, V165, P2156
  3. Bellis SL, 2004, BBA-BIOMEMBRANES, V1663, P52, DOI 10.1016/j.bbamem.2004.03.012
  4. Nickel W, 2003, EUR J BIOCHEM, V270, P2109, DOI 10.1046/j.1432-1033.2003.03577.x
  5. SCHALLER MD, 1995, MOL CELL BIOL, V15, P2635
  6. Brat DJ, 2004, CANCER RES, V64, P920, DOI 10.1158/0008-5472.CAN-03-2073
  7. Lukyanov P, 2005, BIOCHEM BIOPH RES CO, V338, P1031, DOI 10.1016/j.bbrc.2005.10.033
  8. Lau KS, 2007, CELL, V129, P123, DOI 10.1016/j.cell.2007.01.049
  9. LINDSTEDT R, 1993, J BIOL CHEM, V268, P11750
  10. Lagana A, 2006, MOL CELL BIOL, V26, P3181, DOI 10.1128/MCB.26.8.3181-3193.2006
  11. Hsu DK, 2000, AM J PATHOL, V156, P1073, DOI 10.1016/S0002-9440(10)64975-9
  12. Bornstein P, 2001, J CLIN INVEST, V107, P929, DOI 10.1172/JCI12749
  13. Brekken RA, 2000, MATRIX BIOL, V19, P569, DOI 10.1016/S0945-053X(00)00105-0
  14. Lajoie P, 2007, J CELL MOL MED, V11, P644, DOI 10.1111/j.1582-4934.2007.00083.x
  15. Kawachi K, 2000, HUM PATHOL, V31, P428, DOI 10.1053/hp.2000.6534
  16. BELLIS SL, 1995, J BIOL CHEM, V270, P17437
  17. Demetriou M, 2001, NATURE, V409, P733, DOI 10.1038/35055582
  18. Carpi A, 2010, J CELL PHYSIOL, V224, P612, DOI 10.1002/jcp.22187
  19. Inohara H, 1998, EXP CELL RES, V245, P294, DOI 10.1006/excr.1998.4253
  20. MANSER E, 1994, NATURE, V367, P40, DOI 10.1038/367040a0
  21. Tsutsumi R, 2006, MOL CELL BIOL, V26, P261, DOI 10.1128/MCB.26.1.261-276.2006
  22. Califice S, 2004, ONCOGENE, V23, P7527, DOI 10.1038/sj.onc.1207997
  23. Nakamura M, 1999, INT J ONCOL, V15, P143
  24. Saravanan C, 2009, J CELL SCI, V122, P3684, DOI 10.1242/jcs.045674
  25. Guo HB, 2002, CANCER RES, V62, P6837
  26. TOLIAS KF, 1995, J BIOL CHEM, V270, P17656
  27. Openo KP, 2000, EXP CELL RES, V255, P278, DOI 10.1006/excr.1999.4782
  28. Kariya Y, 2010, J BIOL CHEM, V285, P3330, DOI 10.1074/jbc.M109.038836
  29. Bornstein P, 2002, CURR OPIN CELL BIOL, V14, P608, DOI 10.1016/S0955-0674(02)00361-7
  30. Granovsky M, 2000, NAT MED, V6, P306
  31. Levy Y, 2001, J BIOL CHEM, V276, P31285, DOI 10.1074/jbc.M100340200
  32. Jensen-Jarolim E, 2002, EUR J GASTROEN HEPAT, V14, P145, DOI 10.1097/00042737-200202000-00008
  33. Hood JD, 2002, NAT REV CANCER, V2, P91, DOI 10.1038/nrc727
  34. Khanna C, 2001, CANCER RES, V61, P3750
  35. Broussard JA, 2008, CURR OPIN CELL BIOL, V20, P85, DOI 10.1016/j.ceb.2007.10.009
  36. Hughes RC, 1999, BBA-GEN SUBJECTS, V1473, P172, DOI 10.1016/S0304-4165(99)00177-4
  37. Hall A, 1998, SCIENCE, V279, P509, DOI 10.1126/science.279.5350.509
  38. Goetz JG, 2008, J CELL BIOL, V180, P1261, DOI 10.1083/jcb.200709019
  39. Qin ZH, 2002, J EXP MED, V195, P1479, DOI 10.1084/jem.20011887
  40. Hao X, 2010, VET PATHOL, V47, P434, DOI 10.1177/0300985810363705
  41. Keely PJ, 1997, NATURE, V390, P632, DOI 10.1038/37656
  42. Liu FT, 2005, NAT REV CANCER, V5, P29, DOI 10.1038/nrc1527
  43. Hsia DA, 2003, J CELL BIOL, V160, P753, DOI 10.1083/jcb.200212114
  44. Aumailley M, 2005, MATRIX BIOL, V24, P326, DOI 10.1016/j.matbio.2005.05.006
  45. Lampugnani MG, 1999, METH MOL B, V96, P177
  46. Guo HB, 2007, J BIOL CHEM, V282, P22150, DOI 10.1074/jbc.M611518200
  47. Baptiste TA, 2007, EXP CELL RES, V313, P652, DOI 10.1016/j.yexcr.2006.11.005
  48. Hanahan D, 2000, CELL, V100, P57, DOI 10.1016/S0092-8674(00)81683-9
  49. Ochieng J, 1998, BIOCHEM BIOPH RES CO, V246, P788, DOI 10.1006/bbrc.1998.8708
  50. Guvakova MA, 1999, EXP CELL RES, V251, P244, DOI 10.1006/excr.1999.4566
  51. de Melo FHM, 2007, J HISTOCHEM CYTOCHEM, V55, P1015, DOI 10.1369/jhc.7A7174.2007
  52. Cao ZY, 2002, J BIOL CHEM, V277, P42299, DOI 10.1074/jbc.M200981200
  53. Markowska AI, 2010, J EXP MED, V207, P1981, DOI 10.1084/jem.20090121
  54. Brown MC, 2004, PHYSIOL REV, V84, P1315, DOI 10.1152/physrev.00002.2004
  55. Villa-Verde DMS, 2002, EUR J IMMUNOL, V32, P1434, DOI 10.1002/1521-4141(200205)32:5<1434::AID-IMMU1434>3.0.CO;2-M
  56. Silva-Monteiro E, 2007, AM J PATHOL, V170, P546, DOI 10.2353/ajpath.2007.060389
  57. Sato S, 2002, J IMMUNOL, V168, P1813
  58. Murphy-Ullrich JE, 2001, J CLIN INVEST, V107, P785, DOI 10.1172/JCI12609
  59. Wehrle-Haller B, 2003, J PATHOL, V200, P481, DOI 10.1002/path.1399
  60. Danguy A, 2002, BBA-GEN SUBJECTS, V1572, P285, DOI 10.1016/S0304-4165(02)00315-X
  61. Laudanna C, 2002, IMMUNOL REV, V186, P37, DOI 10.1034/j.1600-065X.2002.18604.x
  62. Schafer T, 2004, J BIOL CHEM, V279, P6244, DOI 10.1074/jbc.M310500200
  63. Gong HC, 1999, CANCER RES, V59, P6239
  64. Friedrichs J, 2008, J BIOL CHEM, V283, P32264, DOI 10.1074/jbc.M803634200
  65. Jones PL, 2000, MATRIX BIOL, V19, P581, DOI 10.1016/S0945-053X(00)00106-2
  66. Hirabayashi J, 2002, BBA-GEN SUBJECTS, V1572, P232, DOI 10.1016/S0304-4165(02)00311-2
  67. Goetz JG, 2009, CELL ADHES MIGR, V3, P185, DOI 10.4161/cam.3.2.7295
  68. AVNUR Z, 1981, J MOL BIOL, V153, P361, DOI 10.1016/0022-2836(81)90283-7
  69. Bresalier RS, 1997, CANCER, V80, P776
  70. CHAMMAS R, 1993, P NATL ACAD SCI USA, V90, P1795, DOI 10.1073/pnas.90.5.1795
  71. Furtak V, 2001, BIOCHEM BIOPH RES CO, V289, P845, DOI 10.1006/bbrc.2001.6064
  72. Grassadonia Antonino, 2004, Glycoconjugate Journal, V19, P551
  73. Gray RM, 2008, ARCH BIOCHEM BIOPHYS, V475, P100, DOI 10.1016/j.abb.2008.04.010
  74. HEBERT E, 1994, BIOL CELL, V81, P73, DOI 10.1016/0248-4900(94)90057-4
  75. Iglesias MM, 1998, GLYCOBIOLOGY, V8, P59, DOI 10.1093/glycob/8.1.59
  76. Jasiulionis MG, 1996, CANCER RES, V56, P1682
  77. Kwon M, 2006, ENDOCRINOLOGY, V147, P1458, DOI 10.1210/en.2005-11115
  78. Nangia-Makker Pratima, 2008, Cancer Microenviron, V1, P43, DOI 10.1007/s12307-008-0003-6
  79. Neder L, 2004, BRAIN PATHOL, V14, P399
  80. Rafiq K, 2006, J BIOL CHEM, V281, P19781, DOI 10.1074/jbc.M513040200
  81. VEIGA SS, 1995, INT J CANCER, V61, P420, DOI 10.1002/ijc.2910610324
  82. Zhu WQ, 2001, CANCER RES, V61, P1869
  83. Zhuo Y, 2008, J BIOL CHEM

Coleções
Artigos e Materiais de Revistas Científicas - FM/MDR
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - LIM/24