Unfolded Protein Response: Cause or Consequence of Lipid and Lipoprotein Metabolism Disturbances?

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art_PINTO_Unfolded_Protein_Response_Cause_or_Consequence_of_Lipid_2019.PDF (2.16 MB)
Citações na Scopus
5
Tipo de produção
article
Data de publicação
2019
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
SPRINGER INTERNATIONAL PUBLISHING AG
Autores
PINTO, Bruno Araujo Serra
FRANCA, Lucas Martins
PAES, Antonio Marcus de Andrade
Citação
BIOACTIVE LIPIDS IN HEALTH AND DISEASE, v.1127, p.67-82, 2019
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
The liver plays a capital role in the control of whole body energy homeostasis through the metabolization of dietary carbohydrates and lipids. However, under excess macronutrient uptake, those pathways overcharge nucleus-to-endoplasmic reticulum (ER) traffic pathways, leading to luminal overload of unfolded proteins which activates a series of adaptive signaling pathways known as unfolded protein response (UPR). The UPR is a central network mechanism for cellular stress adaptation, however far from a global nonspecific all-or-nothing response. Such a complex signaling network is able to display considerable specificity of responses, with activation of specific signaling branches trimmed for distinct types of stimuli. This makes the UPR a fundamental mechanism underlying metabolic processes and diseases, especially those related to lipid and carbohydrate metabolism. Thus, for a better understanding of the role of UPR on the physiopathology of lipid metabolism disorders, the concepts discussed along this chapter will demonstrate how several metabolic derangements activate UPR components and, in turn, how UPR triggers several metabolic adaptations through its component signaling proteins. This dual role of UPR on lipid metabolism will certainly foment the pursuit of an answer for the question: is UPR cause or consequence of lipid and lipoprotein metabolism disturbances?
Palavras-chave
Unfolded protein response, ER stress, PERK, IRE-1 alpha, ATF-6
URI
https://observatorio.fm.usp.br/handle/OPI/33297
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Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/64